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tumor of the pineal gland

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/30 06:52:23」(JST)

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Pinealoma is a tumor of the pineal gland.

Presentation[edit]

The pineal gland produces the hormone melatonin which plays a role in regulating circadian rhythms. A pinealoma may disrupt production of this hormone, and insomnia may result.

Frequently, paralysis of upward gaze along with several ocular findings such as convergence retraction nystagmus and eyelid retraction also known as Collier's sign and Light Near Dissociation (pupil accommodates but doesn't react to light) are known collectively as Parinaud's syndrome ^[1] or Dorsal Mid-brain syndrome, are the only physical symptoms seen. This is caused by the compression of the vertical gaze center in the midbrain tectum at the level of the superior colliculus and cranial nerve III. Work-up usually includes Neuro-imaging as seen on the right.

A pinealoma may cause interruption of hypothalamic inhibiting pathways, sometimes leading to beta-hCG secretion and consequent Leydig's cell stimulation.

Other symptoms may include hydrocephalus, gait disturbances, and precocious puberty.

Etiology[edit]

Pinealomas can be due to proliferation of primary pineocytes (pineocytomas, pineoblastomas), astrocytes (astrocytoma), or germ cells (germinoma).^[2] Germinomas are the most common tumor in the pineal gland.

Prognosis[edit]

Of the different types of pinealomas, the type with the most favorable prognosis is the pineocytoma.^[3]

References[edit]

^ Gaspar N, Verschuur A, Mercier G, Couanet D, Sainte-Rose C, Brugières L (September 2003). "Reversible hearing loss associated with a malignant pineal germ cell tumor. Case report". J. Neurosurg. 99 (3): 587–90. doi:10.3171/jns.2003.99.3.0587. PMID 12959450.
^ "eMedicine - Germinoma, Central Nervous System : Article by Daniel D Mais, MD". Retrieved 2007-12-03.
^ Deshmukh VR, Smith KA, Rekate HL, Coons S, Spetzler RF (2004). "Diagnosis and management of pineocytomas". Neurosurgery 55 (2): 349–55; discussion 355–7. doi:10.1227/01.NEU.0000129479.70696.D2. PMID 15271241.

Additional images[edit]

External links[edit]

00322 at CHORUS

UpToDate Contents

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1. 鞍部腫瘤の原因、症状、および評価 causes presentation and evaluation of sellar masses
2. 思春期早発症の定義、原因、および評価 definition etiology and evaluation of precocious puberty
3. 律動眼振 jerk nystagmus

English Journal

Occurrence of Pineal Gland Tumors in Combined Chronic Toxicity/Carcinogenicity Studies in Wistar Rats.

Treumann S1, Buesen R2, Gröters S2, Eichler JO3, Ravenzwaay BV2.
Toxicologic pathology.Toxicol Pathol.2015 Mar 9. pii: 0192623315572700. [Epub ahead of print]
Pineal gland tumors are very rare brain lesions in rats as well as in other species including humans. A total of 8 (out of 1,360 examined) Wistar rats from 3 different combined chronic toxicity/carcinogenicity or mere carcinogenicity studies revealed pineal gland tumors. The tumors were regarded to
PMID 25755100

Dermoscopy of multiple radiation-induced basal cell carcinomas in a patient treated previously for pinealoma.

Siqueira Mde L1, Trope BM1, Cavalcante RB1, Campos-do-Carmo G1, Ramos-E-Silva M1.
Journal of dermatological case reports.J Dermatol Case Rep.2014 Dec 31;8(4):115-7. doi: 10.3315/jdcr.2014.1186. eCollection 2014.
BACKGROUND: Malignancies secondary to radiation, such as radiation-induced skin cancer, are possible consequences of radiation therapy. The most frequent post-radiation skin neoplasm is basal cell carcinoma.MAIN OBSERVATION: We report a case of a 49-year-old woman who underwent multiple radiotherapy
PMID 25621092

Baseline central nervous system magnetic resonance imaging in early detection of trilateral retinoblastoma: pitfalls in the diagnosis of pineal gland lesions.

De Ioris MA1, Valente P2, Randisi F3, Buzzonetti L2, Carai A4, Cozza R5, Del Bufalo F5, Romanzo A2, Angioni A6, Cacchione A5, Bernardi B3, Mastronuzzi A5.
Anticancer research.Anticancer Res.2014 Dec;34(12):7449-54.
BACKGROUND: Trilateral retinoblastoma (TRB) is a rare disease associating bilateral retinoblastoma (RB) with primitive intracranial neuroblastic tumor.AIM: To verify the occurrence of TRB in a single-Center case series and point out the clinical relevance of a baseline brain magnetic resonance imagi
PMID 25503186

Japanese Journal

PinealomaとPineal Parenchymal Tumor(Editorial Comment,脳腫瘍の画像と病理)

杉山一彦
脳神経外科ジャーナル 19(10), 785, 2010-10-20
NAID 110007730752

Crj : CD (SD) IGS系雄ラットに自然発生した松果体腫(短報)

古川賢,小林清,臼田浩二 [他],田村啓,宮本康夫,林憲一,池山聖一,御領政信,岡田幸助
The journal of veterinary medical science 61(1), 41-44, 1999-01-25
61週齢, 雄Crj : CD (SD) IGSラットにおいて, 松果体腫(良性)が認められた. 腫瘍は大脳半球と小脳との間に存在していた. 組織的に腫瘍細胞は多数の明調な大型細胞と少数の暗調小型の細胞よりなっていた. 腫瘍細胞は結合組織により不明瞭な小葉構造あるいは胞巣状構造に区分されていた. 有糸分裂像は比較的豊富であった. 電顕検索では直径約120nmの有芯小胞が散見された.
NAID 110003920032

松果体腫瘍と中脳性難聴 : 2症例の比較検討

都筑俊寛,加我君孝,山田勝士,田村晃
Audiology Japan 41(4), 309-313, 1998-08-31
NAID 10009375753

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★リンクテーブル★

リンク元	「pineal tumor」「pineal neoplasm」「松果体腫」

「pineal tumor」

Pinealoma
	Classification and external resources
	; Pineocytoma
ICD-10	D44.5, C75.3
ICD-9	237.1, 194.4
ICD-O:	M9360/1-9362/3
DiseasesDB	10044
eMedicine	med/2911
MeSH	D010871