WordNet

a chemical reaction in which water reacts with a compound to produce other compounds; involves the splitting of a bond and the addition of the hydrogen cation and the hydroxide anion from the water

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Physiologically induced restructuring of focal adhesions causes mobilization of vinculin by a vesicular endocytic recycling pathway.

Márquez MG1, Brandán YR1, Guaytima Edel V1, Paván CH2, Favale NO3, Sterin-Speziale NB4.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 Dec;1843(12):2991-3003. doi: 10.1016/j.bbamcr.2014.09.014. Epub 2014 Sep 18.
In epithelial cells, vinculin is enriched in cell adhesion structures but is in equilibrium with a large cytosolic pool. It is accepted that when cells adhere to the extracellular matrix, a part of the soluble cytosolic pool of vinculin is recruited to specialized sites on the plasma membrane called
PMID 25241342

Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012).

Shisheva A1, Sbrissa D, Ikonomov O.
BioEssays : news and reviews in molecular, cellular and developmental biology.Bioessays.2014 Nov 18. doi: 10.1002/bies.201400129. [Epub ahead of print]
Recently, we have presented data supporting the notion that PIKfyve not only produces the majority of constitutive phosphatidylinositol 5-phosphate (PtdIns5P) in mammalian cells but that it does so through direct synthesis from PtdIns. Another group, albeit obtaining similar data, suggests an altern
PMID 25404370

Cattaneo F1, Guerra G2, Parisi M3, De Marinis M4, Tafuri D5, Cinelli M6, Ammendola R7.
International journal of molecular sciences.Int J Mol Sci.2014 Oct 29;15(11):19700-19728.
G protein-coupled receptors (GPCRs) are seven transmembrane-spanning proteins belonging to a large family of cell-surface receptors involved in many intracellular signaling cascades. Despite GPCRs lack intrinsic tyrosine kinase activity, tyrosine phosphorylation of a tyrosine kinase receptor (RTK) o
PMID 25356505

Roles of Nicotinic Receptors in Acetylcholinesterase Inhibitor-Induced Neuroprotection and Nicotinic Receptor Up-Regulation(Functional Changes Induced by Long-Term Stimulation of Nicotinic Acetylcholine Receptors)

TAKADA-TAKATORI Yuki,KUME Toshiaki,IZUMI Yasuhiko,OHGI Yuta,NIIDOME Tetsuhiro,FUJII Takeshi,SUGIMOTO Hachiro,AKAIKE Akinori
Biological & pharmaceutical bulletin 32(3), 318-324, 2009-03-01
… Donepezil, galantamine and tacrine are acetylcholinesterase inhibitors used for the treatment of Alzheimer's disease, and were believed to be symptomatic drugs whose therapeutic effects are achieved by slowing the hydrolysis of acetylcholine at synaptic termini. … Our results also demonstrate the important roles of the phosphatidylinositol 3-kinase pathway downstream of nicotinic receptors in protecting neurons from death and up-regulating nicotinic receptors. …
NAID 110007122760

白井隆一,齊藤慎太郎,濱口亜紀,西川明日香
天然有機化合物討論会講演要旨集 (45), 227-232, 2003-09-01
… D- and L-myo-inositol 3,4,5,6-tetrakisphosphate (D-IP4, and L-IP4) and phosphatidylinositol 3,5-bisphosphate(PI 3,5-P2) were recently identified as novel second messengers. … Protection of hydroxyl group, acid hydrolysis, Wittig methylenation and ring-closing metathesis(RCM) gave the conduritol B derivatives(3). …
NAID 110006682298

リンク元	「イノシトールリン脂質加水分解」「phosphatidylinositol metabolism」
関連記事	「hydrolysis」「phosphatidylinositol」