phosphate acetyltransferase

リン酸アセチルトランスフェラーゼ、リン酸アセチル基転移酵素

関

phosphotransacetylase

WordNet

1. a salt of phosphoric acid (同)orthophosphate, inorganic_phosphate
2. carbonated drink with fruit syrup and a little phosphoric acid

PrepTutorEJDIC

1. 〈U〉リン酸塩 / 《複数形で》リン酸肥料

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/08 19:41:26」(JST)

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[Wiki en表示]

acetyl phosphate
Identifiers
EC number	2.3.1.8
CAS number	9029-91-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a phosphate acetyltransferase (EC 2.3.1.8) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + phosphate CoA + acetyl phosphate

Thusrate (biochemistry)|substrates]] of this enzyme are acetyl-CoA and phosphate, whereas its two products are CoA and acetyl phosphate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:phosphate acetyltransferase. Other names in common use include phosphotransacetylase, phosphoacylase, and PTA. This enzyme participates in 3 metabolic pathways: taurine and hypotaurine metabolism, pyruvate metabolism, and propanoate metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1QZT, 1R5J, 1TD9, 1VMI, 1XCO, 2AF3, and 2AF4.

References

• BERGMEYER HU, HOLZ G, KLOTZSCH H, LANG G (1963). "[PHOSPHOTRANSACETYLASE FROM CLOSTRIDIUM KLUYVERI. CULTURE OF THE BACTERIUM, ISOLATION, CRYSTALLIZATION AND PROPERTIES OF THE ENZYME.]". Biochem. Z. 338: 114–21. PMID 14087284. 
• STADTMAN ER (1952). "The purification and properties of phosphotransacetylase". J. Biol. Chem. 196 (2): 527–34. PMID 12980995. 
• Stadtman ER (1955). Stadtman, ER, ed. "Phosphotransacetylase from Clostridium kluyveri". Methods Enzymol. Methods in Enzymology 1: 596–599. doi:10.1016/0076-6879(55)01103-8. ISBN 0-12-181801-2. 

UpToDate Contents

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• 1. カルシウムおよびリン酸バランスの調節 regulation of calcium and phosphate balance
• 2. 高リン血症の原因および治療の概要 overview of the causes and treatment of hyperphosphatemia
• 3. グルコース-6-リン酸脱水素酵素欠損症の診断および治療 diagnosis and treatment of glucose 6 phosphate dehydrogenase deficiency
• 4. 慢性腎疾患における高リン血症の治療 treatment of hyperphosphatemia in chronic kidney disease
• 5. 低リン血症の評価および治療 evaluation and treatment of hypophosphatemia

English Journal

• Bacterial protein acetylation: new discoveries unanswered questions.

• Wolfe AJ1.
• Current genetics.Curr Genet.2015 Dec 12. [Epub ahead of print]
• Nε-acetylation is emerging as an abundant post-translational modification of bacterial proteins. Two mechanisms have been identified: one is enzymatic, dependent on an acetyltransferase and acetyl-coenzyme A; the other is non-enzymatic and depends on the reactivity of acetyl phosphate. Some, but no
• PMID 26660885

• Metabolic engineering of the mixed-acid fermentation pathway of Escherichia coli for anaerobic production of glutamate and itaconate.

• Vuoristo KS1, Mars AE2, Sangra JV3, Springer J4, Eggink G5, Sanders JP6, Weusthuis RA7.
• AMB Express.AMB Express.2015 Dec;5(1):61. doi: 10.1186/s13568-015-0147-y. Epub 2015 Sep 17.
• Itaconic acid, an unsaturated C5-dicarboxylic acid, is a biobased building block for the polymer industry. The purpose of this study was to establish proof of principle for an anaerobic fermentation process for the production of itaconic acid by modification of the mixed acid fermentation pathway of
• PMID 26384341

• High-throughput screen identifies small molecule inhibitors targeting acetyltransferase activity of Mycobacterium tuberculosis GlmU.

• Rani C1, Mehra R2, Sharma R1, Chib R1, Wazir P3, Nargotra A4, Khan IA5.
• Tuberculosis (Edinburgh, Scotland).Tuberculosis (Edinb).2015 Dec;95(6):664-77. doi: 10.1016/j.tube.2015.06.003. Epub 2015 Jul 31.
• N-acetylglucosamine-1-phosphate uridyltransferase (GlmU) is a pivotal bifunctional enzyme, its N and C terminal domains catalyzes uridyltransferase and acetyltransferase activities, respectively. Final product of GlmU catalyzed reaction, uridine-diphospho-N-acetylglucosamine (UDP-GlcNAc), acts as su
• PMID 26318557

Japanese Journal

• 酵母のD-アミノ酸代謝とその関連酵素(第56回大会シンポジウム(II))

• 吉村 徹
• ビタミン 79(5・6), 277-283, 2005-06-25
• … The alanine and arginine racemases depend on pyridoxal 5'-phosphate, and exhibit similar primary structures to those of bacterial alanine racemases. … cerevisiae is reported to posses an enzyme acting on D-amino acids, D-amino acid-N-acetyltransferase, which catalyzes the transfer of the acetyl group from acetyl-CoA to the amino group of various D-amino acids. …
• NAID 110004857257

• Malonate Decarboxylase in Bacteria and Its Application for Determination of Intracellular Acyl-CoA Thioesters

• CHOHNAN SHIGERU,TAKAMURA YOSHICHIKA
• Microbes and environments 19(3), 179-189, 2004-09
• … Moreover, one can separately measure the three CoA molecular species, acetyl-CoA, malonyl-CoA, and nonesterified CoA (CoASH), by a combination of the elimination of acetyl-CoA with citrate synthetase (EC 4.1.3.7) or acetylation of CoASH with phosphate acetyltransferase (EC 2.3.1.8). …
• NAID 110001269374

• Subcellular Localization of Alcohol Acetyltransferase in Strawberry Fruit

• NOICHINDA Sompoch,UEDA Yoshinori,IMAHORI Yoshihiro,CHACHIN Kazuo
• Food science and technology research 5(3), 239-242, 1999-08-01
• … The first step of the extraction of alcohol acetyltransferase (AAT) from fruits is usually achieved by preparation of free-cells with enzymatic maceration of tissues. … The distribution of AAT in the subcellular fraction of the grated pulp was similar to those of glucose-6-phosphate dehydrogenase (cytosolic enzyme) and anthocyanin (vacuolar pigment). …
• NAID 130000061978

Related Links

• phosphate acetyltransferase - definition of phosphate ...

phos·phate a·ce·tyl·trans·fer·ase (fos'fāt a-sē'til-trans'fĕr-ās), An enzyme-catalyzing transfer of an acetyl moiety from acetyl-CoA to orthophosphate, forming acetyl phosphate and coenzyme A. Synonym(s): phosphoacylase, phosphotransacetylase

• pta - Phosphate acetyltransferase - Escherichia coli (strain K12)

Involved in acetate metabolism. Catalyzes the reversible interconversion of acetyl-CoA and acetyl phosphate. The direction of the overall reaction changes depending on growth conditions. On minimal medium acetyl-CoA is generated.

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★リンクテーブル★

リンク元	「リン酸アセチルトランスフェラーゼ」「リン酸アセチル基転移酵素」「phosphotransacetylase」
関連記事	「phosphate」「acetyltransferase」

「リン酸アセチルトランスフェラーゼ」

　　[★]

英

phosphate acetyltransferase

関

リン酸アセチル基転移酵素、ホスホトランスアセチラーゼ

「リン酸アセチル基転移酵素」

　　[★]

英

phosphate acetyltransferase

関

リン酸アセチルトランスフェラーゼ

「phosphotransacetylase」

　　[★]

ホスホトランスアセチラーゼ

関

phosphate acetyltransferase

「phosphate」

　　[★]

• n.

• (化合物)リン酸塩、リン酸エステル、ホスフェート、フォスフェート、リン酸

関

inorganic phosphate、orthophosphate、orthophosphoric acid、phospho、phosphoester、phosphoric、phosphoric acid、phosphoric acid ester、phosphorus

　 　 　

「acetyltransferase」

　　[★]

アセチルトランスフェラーゼ、アセチル基転移酵素、アセチル化酵素

関

transacetylase