periciazine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/26 18:35:26」(JST)

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Periciazine

Systematic (IUPAC) name
10-[3-(4-hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile
Clinical data
Pregnancy category	AU: C
Legal status	AU: Prescription Only (S4) CA: ℞-only UK: Prescription-only (POM)
Routes of administration	Oral
Pharmacokinetic data
Metabolism	Hepatic (mostly via conjugation)
Half-life	12 h
Excretion	Renal
Identifiers
CAS Registry Number	2622-26-6 Y
ATC code	N05AC01
PubChem	CID 4747
DrugBank	DB01608 N
ChemSpider	4585 N
UNII	3405M6FD73 Y
KEGG	D01485 Y
ChEBI	CHEBI:31981 N
ChEMBL	CHEMBL251940 N
Chemical data
Formula	C21H23N3OS
Molecular mass	365.49 g/mol
SMILES C1CN(CCC1O)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C#N
InChI InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2  N Key:LUALIOATIOESLM-UHFFFAOYSA-N  N
N (what is this?)  (verify)

Periciazine (INN), also known as pericyazine (BAN) or propericiazine, is a drug that belongs to the phenothiazine class of typical antipsychotics.

Pericyazine is not approved for sale in the United States. It is commonly sold in Canada under the tradename Neuleptil and in United Kingdom and Australia under the tradename Neulactil.

Medical Uses

The primary uses of pericyazine include in the short-term treatment of severe anxiety or tension and in the maintenance treatment of psychotic disorders such as schizophrenia.

Periciazine has also been studied in the treatment of opioid dependence.

Adverse effects

Pericyazine is a rather sedating and anticholinergic antipsychotic, and despite being classed with the typical antipsychotics, its risk of extrapyramidal side effects is comparatively low. It has a relatively high risk of causing hyperprolactinaemia and a moderate risk of causing weight gain and orthostatic hypotension.

References

External links

• Neulactil - Summary of Product Characteristics from the electronic Medicines Compendium
• [1] from the Therapeutic Goods Administration.
• [2] from Health Canada.

English Journal

• Fifteen-year experience and outcomes of pericardiectomy for constrictive pericarditis.

• Avgerinos D1, Rabitnokov Y, Worku B, Neragi-Miandoab S, Girardi LN.
• Journal of cardiac surgery.J Card Surg.2014 Jul;29(4):434-8. doi: 10.1111/jocs.12344. Epub 2014 Apr 18.
• BACKGROUND AND AIM: Constrictive pericarditis has multiple etiologies and can lead to disabling symptoms and severe heart failure with poor quality of life. Surgical pericardiectomy is the cornerstone of management. All patients undergoing pericardiectomy at our institution were reviewed with the go
• PMID 24750218

• [Severe hypotension and ventricular fibrillation during combined general and epidural anesthesia in a patient on major tranquilizers].

• Futsukaichi K1, Matsumoto K, Fujita K, Abe R, Noguchi T.
• Masui. The Japanese journal of anesthesiology.Masui.2012 Oct;61(10):1121-4.
• A 54-year-old man (height 155 cm, weight 49 kg) was scheduled for retroperitoneoscopic nephrectomy. He had a history of schizophrenia that had been controlled with propericiazine 10 mg and bromperidol 3 mg daily for 34 years. After induction of anesthesia, 1% mepivacaine 5 ml was administered via an
• PMID 23157101

• Incompatibility between propericiazine oral solution and tea-based drink.

• Ikeda H1, Tsuji E, Matsubara T, Yukawa M, Fujisawa M, Yukawa E, Aki H.
• Chemical & pharmaceutical bulletin.Chem Pharm Bull (Tokyo).2012;60(9):1207-11.
• Here, we studied the incompatibility between an oral solution of propericiazine (PCZ), an antipsychotic drug, and various commercially available bottled tea-based drinks. When 0.5 mL of the PCZ oral solution (10 mg/mL) was mixed with 16.5 mL of a tea-based drink (such as green tea, oolong tea, and b
• PMID 22976331

Japanese Journal

• Preparation of Metabolites by Chemical Reaction : Conversion of Antipsychotic Phenothiazines to their Sulfoxides and Tertiary Amino Cyclic Antidepressants to their N-Oxide with Hydrogen Peroxide Using Titanosilicate Catalyst

• Ogamo Akira,Fukumoto Mariko
• Journal of health science 50(4), 396-406, 2004-08-01
• … The purities of the prepared crystallized product of the phenothiazine sulfoxides were good except for periciazine sulfoxide. …
• NAID 110003609182

Related Links

• Pericyazine - Wikipedia, the free encyclopedia

Pericyazine (BAN; also known as periciazine or propericiazine) is a medication that belongs to the phenothiazine class of antipsychotics. It has also been studied in the treatment of opiate dependence. Pericyazine is not approved for sale in ...

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