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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/21 05:52:57」(JST)

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Perfluorobutane (PFB) is a colorless gas. It is a simple fluorocarbon with a n-butane skeleton and all the hydrogen atoms replaced with fluorine atoms. It is used as a replacement for Halon 1301 fire extinguishers,^[3] as well as the gas component for newer generation microbubble ultrasound contrast agents. Sonazoid^[4] is one such microbubble formulation developed by Amersham Health that uses perfluorobutane for the gas core.

References

^ ^a ^b ^c ^d "Perfluorobutane (R610)". Gas Encyclopaedia. Air Liquide. Retrieved November 1, 2012.
^ ^a ^b ^c ^d "Summary Report: PERFLUOROBUTANE".
^ "Perfluorobutane — Full Public Report" (PDF). National Industrial Chemicals Notification and Assessment Scheme. 1996.
^ "Sonoazoid - US TIP".

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English Journal

In Vitro Metabolic Formation of Perfluoroalkyl Sulfonamides from Copolymer Surfactants of Pre- and Post-2002 Scotchgard™ Fabric Protector Products.

Chu S, Letcher RJ.
Environmental science & technology.Environ Sci Technol.2014 May 1. [Epub ahead of print]
Currently there is a scientific debate on whether fluorinated polymers (or copolymers) are a source as a result of their degradation and subsequent formation to perfluorinated carboxylic acids (PFCAs) and perfluorinated alkane sulfonates (PFSAs). The present study investigated whether commercially a
PMID 24784168

RNA Biomarker Release with Ultrasound and Phase-Change Nanodroplets.

Paproski RJ1, Forbrich A1, Hitt M2, Zemp R3.
Ultrasound in medicine & biology.Ultrasound Med Biol.2014 May 1. pii: S0301-5629(14)00020-9. doi: 10.1016/j.ultrasmedbio.2014.01.011. [Epub ahead of print]
Microbubbles driven by ultrasound are capable of permeabilizing cell membranes and allowing biomarkers or therapeutics to exit from or enter cancer cells, respectively. Unfortunately, the relatively large size of microbubbles prevents extravasation. Lipid-based perfluorobutane microbubbles can be ma
PMID 24792584

The usefulness of contrast-enhanced ultrasound with Sonazoid for evaluating liver abscess in comparison with conventional B-mode ultrasound.

Kishina M1, Koda M, Tokunaga S, Miyoshi K, Fujise Y, Kato J, Matono T, Sugihara T, Murawaki Y.
Hepatology research : the official journal of the Japan Society of Hepatology.Hepatol Res.2014 Apr 28. doi: 10.1111/hepr.12347. [Epub ahead of print]
BACKGROUND/AIM: The purpose of this study was to evaluate the usefulness of contrast-enhanced ultrasound (CEUS) with Sonazoid (perfluorobutane) in patients with liver abscess. Sonazoid is a contrast agent with a low mechanical index and is phagocytosed by Kupffer cells.METHODS: Twenty-two patients w
PMID 24773617

Japanese Journal

超音波造影剤ペルフルブタンの臨床上の安全性ならびに有用性の検討

森義弘,早川晶子,阿部研自,谷川雅俊,高橋周美,成瀬英典,山口文恵
Japanese journal of medical ultrasonics = 超音波医学 38(5), 541-548, 2011-09-15
NAID 10029742736

Imaging of acquired cystic disease-associated renal cell carcinoma by contrast-enhanced ultrasonography with perflubutane microbubbles and positron emission tomography-computed tomography

ISHIKAWA Isao,MORITA Kyoko,HAYAMA Satoshi,NAKAZAWA Tetsuya,ARAKI Ichiro,HIGASHI Kotaro,MIYAZAWA Katsuhito,SUZUKI Koji,NOJIMA Takayuki
Clinical and experimental nephrology 15(1), 136-140, 2011-02-01
NAID 10029004761

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「ペルフルブタン」

Perfluorobutane
Names
	Other names Decafluorobutane (DFB); Perflubutane (USAN); Halocarbon 610; R610
Identifiers
CAS Number	355-25-9
ChemSpider	13862701
EC Number	206-580-3
	InChI InChI=1S/C4F10/c5-1(6,3(9,10)11)2(7,8)4(12,13)14 Key: KAVGMUDTWQVPDF-UHFFFAOYSA-N ; InChI=1/C4F10/c5-1(6,3(9,10)11)2(7,8)4(12,13)14 Key: KAVGMUDTWQVPDF-UHFFFAOYAC ;
Jmol interactive 3D	Image
KEGG	D05440
PubChem	9638
	SMILES C(C(C(F)(F)F)(F)F)(C(F)(F)F)(F)F ;
Properties
Chemical formula	C4F10
Molar mass	238.03 g·mol−1
Density	11.21 kg/m3 (gas, 101.3 kPa at boiling point); 1594 kg/m3 (liquid, 101.3 kPa at boiling point)
Melting point	−128 °C (−198 °F; 145 K)
Boiling point	−1.7 °C (28.9 °F; 271.4 K)
Solubility in water	1.5 mg/L (101.3 kPa)
log P	> 3.93 (n-octanol/water)
Vapor pressure	330.3 kPa (at 25 °C)
Viscosity	0.0001218 Poise
Hazards
Safety data sheet	MSDS at Linde Gas
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

　　[★]

英: perflubutane
商: ソナゾイド
関: その他の診断用薬

[airliquide-1] "Perfluorobutane (R610)". Gas Encyclopaedia. Air Liquide. Retrieved November 1, 2012.

[aus_health-2] "Summary Report: PERFLUOROBUTANE".

[3] "Perfluorobutane — Full Public Report" (PDF). National Industrial Chemicals Notification and Assessment Scheme. 1996.

[4] "Sonoazoid - US TIP".

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perflubutane