English Journal

Cytotoxicity of dental compounds towards human oral squamous cell carcinoma and normal oral cells.

Koh T, Machino M, Murakami Y, Umemura N, Sakagami H.SourceDivision of Pharmacology, Meikai University School of Dentistry, Sakado, Saitama 350-0283, Japan. sakagami@dent.meikai.ac.jp.
In vivo (Athens, Greece).In Vivo.2013 Jan-Feb;27(1):85-95.
AIM: The cytotoxicity of four dental compounds, hydroquinone, benzoquinone, eugenol and phtharal towards human oral squamous cell carcinoma (OSCC) cell lines, normal human oral cells (gingival fibroblast, pulp cell, periodontal ligament fibroblast) and skin keratinocytes was investigated.MATERIALS A
PMID 23239856

The effect of chemotherapy or radiotherapy on thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in cancer of the uterine cervix.

Hasegawa K, Okamoto H, Kawamura K, Kato R, Kobayashi Y, Sekiya T, Udagawa Y.SourceDepartment of Obstetrics and Gynecology, Fujita Health University School of Medicine, Japan. khase@fujita-hu.ac.jp
European journal of obstetrics, gynecology, and reproductive biology.Eur J Obstet Gynecol Reprod Biol.2012 Jul;163(1):67-70. doi: 10.1016/j.ejogrb.2012.03.014. Epub 2012 Apr 3.
OBJECTIVE: Levels of 5-FU metabolic or related enzymes, particularly thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD), have been investigated in various cancer types, including uterine cervical cancer. Intratumoral TP levels have been reported to increase in response to several
PMID 22480411

Coordination chemistry and solution structure of Fe(II)-peplomycin. Two possible coordination geometries.

Li Y, Lehmann T.SourceDepartment of Chemistry, University of Wyoming, 1000 E. University Avenue, Laramie, WY 82071, United States.
Journal of inorganic biochemistry.J Inorg Biochem.2012 Jun;111:50-8. doi: 10.1016/j.jinorgbio.2012.02.020. Epub 2012 Mar 4.
The solution structure of Fe(II)-peplomycin was determined from NMR data collected for this molecule. As found previously for Fe(II)- and Co(II)-bound bleomycin; the coordination sphere of the metal is composed of the primary and secondary amines in β-aminoalanine, the pyrimidine and imidazole ring
PMID 22484500

Japanese Journal

NMR study of peplomycin in aqueous solution : Assignment of resonances by means of two-dimensional spectroscopy

藤原邦雄
YAKUGAKU ZASSHI 131(6), 949-960, 2011
… This review describes preparation of anti-drug antibody, specificity of antibody, fixation of drug in situ in rat tissues and cells, treatment of paraffin section specimens prior to immunoreaction, precision, and their application to a variety of types of antibiotics anti-cancer anthracyclines daunorubicin, doxorubicin, and epirubicin, bleomycin analog peplomycin, antimicrobial agents gentamicin, and amoxicillin. …
NAID 130000926981

春山護人,杉田和成,川上千佳 [他],中村元信,戸倉新樹
産業医科大学雑誌 32(2), 155-159, 2010-06-01
皮膚有棘細胞癌は,リンパ行性転移をきたしやすいことで知られているが,脊椎への転移は極めて稀である.今回我々は,皮膚有棘細胞癌の胸椎転移例を経験したので報告する.症例は,73歳男性.2005年11月に右4趾皮膚有棘細胞癌に対して,原発部の切除と右鼠径リンパ節郭清術を施行した(T2N1M1).以後3年間,多発リンパ節転移に対して,ペプロマイシン投与とCAV療法(シスプラチン,アドリアマイシン,フィルデ …
NAID 110007618645