WordNet
- provide with a patch; also used metaphorically; "The field was patched with snow"
- mend by putting a patch on; "patch a hole" (同)patch up
- a piece of cloth used as decoration or to mend or cover a hole
- a short set of commands to correct a bug in a computer program
- to join or unite the pieces of; "patch the skirt" (同)piece
- exactly suited to the occasion; "a pat reply"
- the sound made by a gentle blow (同)rap, tap
- completely or perfectly; "he has the lesson pat"; "had the system down pat"
- impose or inflict forcefully; "The military government clamped a curfew onto the capital"
- a device (generally used by carpenters) that holds things firmly together (同)clinch
- fasten or fix with a clamp; "clamp the chair together until the glue has hardened"
- the act of making a record (especially an audio record); "she watched the recording from a sound-proof booth" (同)transcription
- a signal that encodes something (e.g., picture or sound) that has been recorded
- a storage device on which information (sounds or images) have been recorded
- gather clams, by digging in the sand by the ocean
- burrowing marine mollusk living on sand or mud; the shell closes with viselike firmness
- flesh of either hard-shell or soft-shell clams
PrepTutorEJDIC
- (補修・補強のための)『つぎ当て』;当て布;当て板,当て金;(アップリケで縫いつけた)布切れ / (傷口などを覆う)『傷当て』 / (色などが周囲と区別できる)(…の)まだら,班点;断片,破片《+『of』+『名』》 / 小さな地面(畑) / (補修・補強のために)…‘に'『つぎ当てる』;(装飾のために)…‘に'当て布をする / …‘を'つぎ合わせて作る
- (愛情・賞賛などを表して手のひらで)…‘を'『軽くたたく』,ポンとたたく / (へらなどで)(…の形に)…‘を'軽くたたいて整える《+『名』+『into』+『名』》 / 『軽くたたくこと』 / その音 / (バターなどの)小さいかたまり《+『of』+『名』》
- きっちりした,ぴってりの / きっちりに,ぴったりと
- patent / patented
- かすがい,締めくぎ,万力 / {動}〈他〉 / …'を'かすがい(万力など)で締めつける
- (土をかぶせて貯蔵してある)じゃがいも(根菜)の山
- 〈C〉録音したもの;レコード,テープ / 〈U〉録音された音
- ハマグリ / ハマグリを取る
UpToDate Contents
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- 1. パッチテスト patch testing
- 2. 経皮吸収避妊パッチ transdermal contraceptive patch
- 3. 新生児の包皮環状切除の手技 techniques for neonatal circumcision
- 4. 神経筋接合部の電気診断学的評価 electrodiagnostic evaluation of the neuromuscular junction
- 5. 成人における禁煙のための薬物療法 pharmacotherapy for smoking cessation in adults
English Journal
- Role of ion channels and subcellular Ca2+ signalling in arachidonic acid induced dilation of pressurised retinal arterioles.
- Kur J1, McGahon M, Fernández JA, Scholfield N, McGeown JG, Curtis T.Author information 1Queen's University Belfast, Belfast, BT12 6BA, Northern Ireland.AbstractPurpose: To investigate the mechanisms responsible for the dilatation of rat retinal arterioles in response to arachidonic acid (AA). Methods: Changes in the diameter of isolated, pressurized rat retinal arterioles were measured in the presence of AA alone and following pre-incubation with pharmacological agents inhibiting Ca2+ sparks and oscillations and K+ channels. Subcellular Ca2+ signals were recorded in arteriolar myocytes using Fluo-4-based confocal imaging. The effects of AA on membrane currents of retinal arteriolar myocytes were studied using whole-cell perforated patch clamp recording. Results: AA dilated pressurised retinal arterioles under conditions of myogenic tone. Eicosatetraynoic acid (ETYA) exerted a similar effect, but unlike AA, its effects were rapidly reversible. AA-induced dilation was associated with an inhibition of subcellular Ca2+ signals. Interventions known to block Ca2+ sparks and oscillations in retinal arterioles caused dilatation and inhibited AA-induced vasodilator responses. AA accelerated the rate of inactivation of the A-type Kv current and the voltage dependence of inactivation was shifted to more negative membrane potentials. It also enhanced voltage-activated and spontaneous BK currents, but only at positive membrane potentials. Pharmacological inhibition of A-type Kv and BK currents failed to block AA-induced vasodilator responses. AA suppressed L-type Ca2+ currents. Conclusions: These results suggest that AA induces retinal arteriolar vasodilation by inhibiting subcellular Ca2+ signalling activity in retinal arteriolar myocytes, most likely through a mechanism involving the inhibition of L-type Ca2+ channel activity. AA actions on K+ currents are inconsistent with a model in which K+ channels contribute to the vasodilator effects of AA.
- Investigative ophthalmology & visual science.Invest Ophthalmol Vis Sci.2014 Apr 3. pii: iovs.13-13511v1. doi: 10.1167/iovs.13-13511. [Epub ahead of print]
- Purpose: To investigate the mechanisms responsible for the dilatation of rat retinal arterioles in response to arachidonic acid (AA). Methods: Changes in the diameter of isolated, pressurized rat retinal arterioles were measured in the presence of AA alone and following pre-incubation with pharmacol
- PMID 24699382
- Dorsal Raphe Serotonin Neurons in Mice: Immature Hyperexcitability Transitions to Adult State during First Three Postnatal Weeks Suggesting Sensitive Period for Environmental Perturbation.
- Rood BD1, Calizo LH, Piel D, Spangler ZP, Campbell K, Beck SG.Author information 1Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, and Department of Anesthesiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104.AbstractTrauma during early life is a major risk factor for the development of anxiety disorders and suggests that the developing brain may be particularly sensitive to perturbation. Increased vulnerability most likely involves altering neural circuits involved in emotional regulation. The role of serotonin in emotional regulation is well established, but little is known about the postnatal development of the raphe where serotonin is made. Using whole-cell patch-clamp recording and immunohistochemistry, we tested whether serotonin circuitry in the dorsal and median raphe was functionally mature during the first 3 postnatal weeks in mice. Serotonin neurons at postnatal day 4 (P4) were hyperexcitable. The increased excitability was due to depolarized resting membrane potential, increased resistance, increased firing rate, lack of 5-HT1A autoreceptor response, and lack of GABA synaptic activity. Over the next 2 weeks, membrane resistance decreased and resting membrane potential hyperpolarized due in part to potassium current activation. The 5-HT1A autoreceptor-mediated inhibition did not develop until P21. The frequency of spontaneous inhibitory and excitatory events increased as neurons extended and refined their dendritic arbor. Serotonin colocalized with vGlut3 at P4 as in adulthood, suggesting enhanced release of glutamate alongside enhanced serotonin release. Because serotonin affects circuit development in other brain regions, altering the developmental trajectory of serotonin neuron excitability and release could have many downstream consequences. We conclude that serotonin neuron structure and function change substantially during the first 3 weeks of life during which external stressors could potentially alter circuit formation.
- The Journal of neuroscience : the official journal of the Society for Neuroscience.J Neurosci.2014 Apr 2;34(14):4809-21. doi: 10.1523/JNEUROSCI.1498-13.2014.
- Trauma during early life is a major risk factor for the development of anxiety disorders and suggests that the developing brain may be particularly sensitive to perturbation. Increased vulnerability most likely involves altering neural circuits involved in emotional regulation. The role of serotonin
- PMID 24695701
- The use of antibody modified liposomes loaded with AMO-1 to deliver oligonucleotides to ischemic myocardium for arrhythmia therapy.
- Liu M1, Li M1, Sun S1, Li B2, Du D1, Sun J2, Cao F1, Li H1, Jia F3, Wang T3, Chang N1, Yu H1, Wang Q4, Peng H5.Author information 1Department of Pharmaceutics, Daqing Campus of Harbin Medical University, Daqing 163319, China.2Department of Pharmaceutics, Harbin Medical University, Harbin 150086, China.3Department of Chemical and Biological Engineering, Ames, IA 50011, USA.4Department of Chemical and Biological Engineering, Ames, IA 50011, USA; Department of Civil, Construction and Environmental Engineering, Iowa State University, Ames, IA 50011, USA.5Department of Pharmaceutics, Daqing Campus of Harbin Medical University, Daqing 163319, China; Department of Chemical and Biological Engineering, Ames, IA 50011, USA. Electronic address: fisher1688@163.com.AbstractMicroRNA-1 (miR-1) has been found in cardiac and skeletal tissues. It is overexpressed in ischemic cardiac tissues. Down-regulation of miR-1 could relieve arrhythmogenesis by the anti-miR-1 antisense oligonucleotides (AMO-1). To increase the therapeutic efficiency and inhibit off-target effects of AMO-1, here we explored anti-cardiac troponin I (cTnI) antibody modified liposomes loading with AMO-1 (cT-A-LIP) to deliver the oligonucleotides to ischemic myocardium tissues. Liposomal cytotoxicity was assessed by MTT assay. The targeting abilities to foci were evaluated by in vivo imaging. The uptake and bio-distribution in vitro were observed by live cell station and flow cytometry, respectively. The anti-arrhythmic effects of cT-A-LIP in vivo were evaluated by electrocardiograms (ECG), immunohistochemistry, real-time PCR and patch-clamp recording. Immunohistochemistry showed that cTnI expression had a peak at the third day after myocardial infarction (MI). After cT-LIP administration via tail vein, accumulation of fluorescent trackers in the ischemic foci was significantly increased more than that of LIP. In addition, after cT-A-LIP administration, the ischemic arrhythmias were recovered and ST segment in ECG was elevated nearly back to normal. Compared with MI group, miR-1 expression was significantly down-regulated while Kir2.1 and CX43 protein expression were increased. Patch-clamp recordings showed that cT-A-LIP as well as AMO-1 incubation increased K(+) current density in guinea pigs ventricular cardiomyocytes acting on repolarized membrane potential. In conclusion, the cT-A-LIP not only delivered AMO-1 to ischemic myocardium in MI rats, but validated AMO-1 on relieving ischemic arrhythmia by silencing of miR-1 in ischemic myocardium and restoring the depolarized resting membrane potential (RMP) in MI rats.
- Biomaterials.Biomaterials.2014 Apr;35(11):3697-707. doi: 10.1016/j.biomaterials.2013.12.099. Epub 2014 Jan 24.
- MicroRNA-1 (miR-1) has been found in cardiac and skeletal tissues. It is overexpressed in ischemic cardiac tissues. Down-regulation of miR-1 could relieve arrhythmogenesis by the anti-miR-1 antisense oligonucleotides (AMO-1). To increase the therapeutic efficiency and inhibit off-target effects of A
- PMID 24468403
Japanese Journal
- カイコガ触角葉における２種類の局所介在神経の電気生理学的解析
- 比較生理生化学 32(4), 205-217, 2015
- NAID 130005116605
- Electrophysiological characteristics of IB4-negative TRPV1-expressing muscle afferent DRG neurons
- BIOPHYSICS 11(0), 9-16, 2015
- NAID 130004940806
- 3P-193 動物・植物のオルガネラ膜イオン輸送体の酵母液胞膜を用いた機能解析(生物化学工学,一般講演)
- 日本生物工学会大会講演要旨集 66, 243, 2014-08-05
- NAID 110009906874
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| 拡張検索 | 「perforated patch-clamp recording」 |
| 関連記事 | 「clamp」「clam」「recording」「patch」 |
「perforated patch-clamp recording」
「clamp」
- n.
- v.
- クランプする
「clam」
- n.
「recording」
「patch」