パルナパリン
- 関
- parnaparin sodium
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/11/28 18:50:04」(JST)
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Parnaparin sodium |
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Parnaparin is an antithrombotic and belongs to the group of low molecular weight heparins.
External links
- parnaparin at the US National Library of Medicine Medical Subject Headings (MeSH)
- Maugeri N, Di Fabio G, Barbanti M, de Gaetano G, Donati MB, Cerletti C (2007). "Parnaparin, a low-molecular-weight heparin, prevents P-selectin-dependent formation of platelet-leukocyte aggregates in human whole blood". Thromb. Haemost. 97 (6): 965–73. doi:10.1160/th06-12-0680. PMID 17549299.
Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01) |
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| Antiplatelet drugs | | Glycoprotein IIb/IIIa inhibitors |
- Abciximab
- Eptifibatide
- Orbofiban
- Roxifiban
- Sibrafiban§
- Tirofiban
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| ADP receptor/P2Y12 inhibitors |
- Thienopyridines
- Clopidogrel
- Prasugrel
- Ticlopidine
- Nucleotide/nucleoside analogs
- Cangrelor
- Elinogrel
- Ticagrelor
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| Prostaglandin analogue (PGI2) |
- Beraprost
- Iloprost
- Prostacyclin
- Treprostinil
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| COX inhibitors |
- Acetylsalicylic acid/Aspirin#
- Aloxiprin
- Carbasalate calcium
- Indobufen
- Triflusal
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| Thromboxane inhibitors |
- Thromboxane synthase inhibitors
- Dipyridamole (+ aspirin)
- Picotamide
- Terbogrel
- Receptor antagonists
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| Phosphodiesterase inhibitors |
- Cilostazol
- Dipyridamole
- Triflusal
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| Other |
- Cloricromen
- Ditazole
- Vorapaxar
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| Anticoagulants | Vitamin K antagonists
(inhibit II, VII, IX, X) |
- Coumarins: Acenocoumarol
- Coumatetralyl
- Dicoumarol
- Ethyl biscoumacetate
- Phenprocoumon
- Warfarin#
- 1,3-Indandiones: Clorindione
- Diphenadione
- Phenindione
- Other: Tioclomarol
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Factor Xa inhibitors
(with some II inhibition) | Heparin group/
glycosaminoglycans/
(bind antithrombin) |
- Low molecular weight heparin
- Bemiparin
- Certoparin
- Dalteparin
- Enoxaparin
- Nadroparin
- Parnaparin
- Reviparin
- Tinzaparin
- Oligosaccharides
- Fondaparinux
- Idraparinux§
- Heparinoids
- Danaparoid
- Dermatan sulfate
- Sulodexide
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| Direct Xa inhibitors ("xabans") |
- Apixaban
- Betrixaban
- Darexaban§
- Edoxaban
- Otamixaban§
- Rivaroxaban
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| Direct thrombin (IIa) inhibitors |
- Bivalent: Hirudin
- Bivalirudin
- Desirudin
- Lepirudin
- Univalent: Argatroban
- Dabigatran
- Efegatran
- Inogatran§
- Melagatran‡
- Ximelagatran‡
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| Other |
- Antithrombin III
- Defibrotide
- Protein C
- Ramatroban
- REG1
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Thrombolytic drugs/
fibrinolytics |
- Plasminogen activators: r-tPA
- Alteplase
- Reteplase
- Tenecteplase
- Desmoteplase†
- UPA
- Anistreplase
- Monteplase
- Streptokinase#
- Other serine endopeptidases: Ancrod
- Brinase
- Fibrinolysin
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| Non-medicinal | |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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UpToDate Contents
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English Journal
- The effect of parnaparin sodium on in vitro fertilization outcome: A prospective randomized controlled trial.
- Lodigiani C1, Dentali F2, Banfi E3, Ferrazzi P3, Librè L3, Quaglia I3, Cafaro L4, Morenghi E5, Pacetti V3, Zannoni E4, Baggiani AM4, Levi-Setti PE4.
- Thrombosis research.Thromb Res.2017 Nov;159:116-121. doi: 10.1016/j.thromres.2017.08.006. Epub 2017 Aug 15.
- PMID 28826740
- Low molecular weight heparins prevent the induction of autophagy of activated neutrophils and the formation of neutrophil extracellular traps.
- Manfredi AA1, Rovere-Querini P1, D'Angelo A2, Maugeri N3.
- Pharmacological research.Pharmacol Res.2017 Sep;123:146-156. doi: 10.1016/j.phrs.2016.08.008. Epub 2017 Feb 1.
- PMID 28161237
- MMX® technology and its applications in gastrointestinal diseases.
- Nardelli S1, Pisani LF2, Tontini GE2, Vecchi M3, Pastorelli L3.
- Therapeutic advances in gastroenterology.Therap Adv Gastroenterol.2017 Jul;10(7):545-552. doi: 10.1177/1756283X17709974. Epub 2017 May 25.
- PMID 28804515
Japanese Journal
- 各種低分子ヘパリンの出血時間と凝固能に関する検討 低分子ヘパリンはどれも同じか？:低分子ヘパリンはどれも同じか?
- 血液透析患者の脂質代謝に及ぼす非分画ヘパリンの病因的意義 低分子量ヘパリンとの比較検討:低分子量ヘパリンとの比較検討
- 血液透析用血液凝固阻止剤としてのｐａｒｎａｐａｒｉｎ ｓｏｄｉｕｍ（ＬＨＧ）の効果 イヌ血液透析モデルにおける単回投与法の検討
Related Links
- 第十六改正日本薬局方 化学薬品等 パルナパリンナトリウム Parnaparin Sodium 本品は健康なブタの腸粘膜から得たヘパリンナトリウムを，過酸化水素及び酢酸第二銅を用いて，又は次亜塩素酸ナトリウムを用いて分解して得た低分子量へ ...
- Synopsis Parnaparin is a low molecular weight (LMW) heparin which, like other members of its class, apparently demonstrates a greater antithrombotic effect relative to its anticoagulan ... Various sections of the manuscript reviewed ...
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