WordNet

an abnormal passage leading from a suppurating cavity to the body surface (同)sinus
of or involving the pancreas; "pancreatic cancer"

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瘻(ろう)菅(長い菅状になった潰瘍)
膵臓の

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/28 13:28:56」(JST)

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A pancreatic fistula is an abnormal communication between the pancreas and other organs due to leakage of pancreatic secretions from damaged pancreatic ducts. An external pancreatic fistula is one that communicates with the skin, and is also known as a pancreaticocutaneous fistula, whereas an internal pancreatic fistula communicates with other internal organs or spaces. Pancreatic fistulas can be caused by pancreatic disease, trauma, or surgery.

External Pancreatic Fistulas

An external pancreatic fistula is an abnormal communication between the pancreas (actually pancreatic duct) and the exterior of the body via the abdominal wall.

Loss of bicarbonate-rich pancreatic fluid via a pancreatic fistula can result in a hyperchloraemic or normal anion gap metabolic acidosis. Loss of a small volume of fluid will not cause a problem but an acidosis is common if the volume of pancreatic fluid lost from the body is large.

Internal Pancreatic Fistulas

First described by Smith (1953),^[1] and elaborated upon by Cameron et al. (1976),^[2] internal pancreatic fistulas can result in pancreatic ascites, mediastinital pseudocysts, enzymatic mediastinitis, or pancreatic pleural effusions, depending on the flow of pancreatic secretions from a disrupted pancreatic duct or leakage from a pseudocyst.^[2]

Clinical Characteristics

Marked recent weight loss is a major clinical manifestation, and unresponsiveness of the ascites to diuretics is an additional diagnostic clue.

Pathogenesis

Internal pancreatic fistulas are most commonly cause by disruption of the pancreatic duct due to chronic pancreatitis. The chronic pancreatitis is usually alcoholic in origin in adults, and traumatic in origin in children. They may also be caused by leakage from a pancreatic pseudocyst.

Anterior disruption of a pseudocyst or a pancreatic duct leads to leakage of pancreatic secretions into the free peritoneal cavity, leading to pancreatic ascites. If the duct is disrupted posteriorly, the secretions leak through the retroperitoneum into the mediastinum via the aortic or esophageal hiatus. Once in the mediastinum, the secretions can either be contained in a mediastinal pseudocyst, lead to enzymatic mediastinitis, or, more commonly, leak through the pleura to enter the chest and form a chronic pancreatic pleural effusion.

Diagnosis

Pleural or ascitic fluid should be sent for analysis. An elevated amylase level, usually > 1,000 IU/L, with protein levels over 3.0 g/dL is diagnostic. Serum amylase is often elevated as well, due to enzyme diffusion across the peritoneal or pleural surface.^[2]^[3] Contrast-enhanced computed tomography and endoscopic retrograde cholangiopancreatography (ERCP) may also assist in diagnosis, with the latter an essential component of treatment.

Treatment

The production of pancreatic enzymes is suppressed by restricting the patient's oral intake of food patient in conjunction with the use of long-acting somatostatin analogues. The patient's nutrition is maintained by total parenteral nutrition. This treatment is continued for 2–3 weeks, and the patient is observed for improvement. If no improvement is seen, the patient may receive endoscopic or surgical treatment. If surgical treatment is followed, an ERCP is needed to identify the site of the leak.

Fistulectomy is done in which the involved part of the pancreas is also removed.

References

^ Smith EB (1953). "Hemorrhagic ascites and hemothorax associated with benign pancreatic disease". AMA Arch Surg 67 (1): 52–6. PMID 13064942.
^ ^a ^b ^c Cameron JL, Kieffer RS, Anderson WJ, Zuidema GD (1976). "Internal pancreatic fistulas: pancreatic ascites and pleural effusions". Ann Surg 184 (5): 587–93. doi:10.1097/00000658-197611000-00009. PMC 1345487. PMID 984927.
^ Lipsett PA, Cameron JL (1992). "Internal pancreatic fistula". Am J Surg 163 (2): 216–20. doi:10.1016/0002-9610(92)90104-Y. PMID 1739176.

Brooks JR (1983). "Pancreatic ascites". In Brooks JR. Surgery of the Pancreas (1st ed.). Philadelphia: WB Saunders. pp. 230–232. ISBN 0-7216-2082-5
Dugernier T, Laterre PF, Reynaert MS (2000). "Ascites fluid in severe acute pancreatitis: from pathophysiology to therapy". Acta Gastroenterol Belg 63 (3): 264–8. PMID 11189983.
Iacono C, Procacci C, Frigo F, Andreis IA, Cesaro G, Caia S, Bassi C, Pederzoli P, Serio G, Dagradi A (1989). "Thoracic complications of pancreatitis". Pancreas 4 (2): 228–36. doi:10.1097/00006676-198904000-00012. PMID 2755944.
Kaman L, Behera A, Singh R, Katariya RN (2001). "Internal pancreatic fistulas with pancreatic ascites and pancreatic pleural effusions: recognition and management". ANZ J Surg 71 (4): 221–5. doi:10.1046/j.1440-1622.2001.02077.x. PMID 11355730.
Takeo C, Myojo S (2000). "Marked effect of octreotide acetate in a case of pancreatic pleural effusion". Curr Med Res Opin 16 (3): 171–7. doi:10.1185/030079900750120269. PMID 11191006.

UpToDate Contents

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1. 膵液瘻：マネージメント pancreatic fistulas management
2. 膵液瘻：臨床的特徴および診断 pancreatic fistulas clinical manifestations and diagnosis
3. 膵体および膵体尾部病変の外科的切除 surgical resection of lesions of the body and tail of the pancreas
4. 膵デブリドマン pancreatic debridement
5. 膵体頭部病変の外科的切除 surgical resection of lesions of the head of the pancreas

English Journal

250 robotic pancreatic resections: safety and feasibility.

Zureikat AH, Moser AJ, Boone BA, Bartlett DL, Zenati M, Zeh HJ 3rd.Source*Division of GI Surgical Oncology, General Surgery †Epidemiology, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA ‡Institute for Hepatobiliary and Pancreatic Surgery, Department of Surgery BIDMC, Boston, MA.
Annals of surgery.Ann Surg.2013 Oct;258(4):554-62. doi: 10.1097/SLA.0b013e3182a4e87c.
BACKGROUND AND OBJECTIVES: Computer-assisted robotic surgery allows complex resections and anastomotic reconstructions to be performed with nearly identical standards to open surgery. We applied this technology to a variety of pancreatic resections to assess the safety, feasibility, versatility, and
PMID 24002300

Retroperitoneal laparoscopic debridement and drainage of infected retroperitoneal necrosis in severe acute pancreatitis.

Tu Y, Jiao H, Tan X, Wang D, Du J, Sun L, Zhang W.SourceDepartment of Hepatobiliary Surgery, First Affiliated Hospital of People's Liberation Army (PLA) General Hospital, Beijing, China.
Asian journal of surgery / Asian Surgical Association.Asian J Surg.2013 Oct;36(4):159-64. doi: 10.1016/j.asjsur.2013.04.003. Epub 2013 Jun 17.
OBJECTIVE: To explore the effect of retroperitoneal laparoscopic debridement and drainage on infected necrosis in severe acute pancreatitis.MATERIALS AND METHODS: This retrospective study included 18 patients with severe acute pancreatitis (SAP) undergoing retroperitoneal laparoscopic debridement an
PMID 23786806

Assessing the impact of a fistula after a pancreaticoduodenectomy using the Post-operative Morbidity Index.

Miller BC, Christein JD, Behrman SW, Callery MP, Drebin JA, Kent TS, Pratt WB, Lewis RS Jr, Vollmer CM Jr.SourceDepartments of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
HPB : the official journal of the International Hepato Pancreato Biliary Association.HPB (Oxford).2013 Oct;15(10):781-8. doi: 10.1111/hpb.12131. Epub 2013 Jul 22.
BACKGROUND: The Post-operative Morbidity Index (PMI) is a quantitative utility measure of a complication burden created by severity weighting. The Fistula Risk Score (FRS) is a validated model that predicts whether a patient will develop a post-operative pancreatic fistula (POPF). These novel tools
PMID 23869603