オキサゾラム
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/02 05:15:01」(JST)
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Oxazolam
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| Systematic (IUPAC) name |
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10-chloro-2-methyl-11b-phenyl-2,3,7,11b-tetrahydrobenzo[f]oxazolo[3,2-d][1,4]diazepin-6(5H)-one
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| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
| Legal status |
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| Identifiers |
| CAS Registry Number |
24143-17-7 Y |
| ATC code |
None |
| PubChem |
CID: 62779 |
| ChemSpider |
56519 Y |
| UNII |
1V2WI2NA1C Y |
| KEGG |
D01278 Y |
| Synonyms |
Oxazolazepam |
| Chemical data |
| Formula |
C18H17ClN2O2 |
| Molecular mass |
328.80 |
SMILES
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Clc2ccc1NC(=O)CN3C[C@H](O[C@]3(c1c2)c4ccccc4)C
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InChI
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InChI=1S/C18H17ClN2O2/c1-12-10-21-11-17(22)20-16-8-7-14(19)9-15(16)18(21,23-12)13-5-3-2-4-6-13/h2-9,12H,10-11H2,1H3,(H,20,22)/t12-,18+/m1/s1 Y
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Key:VCCZBYPHZRWKFY-XIKOKIGWSA-N Y
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| Y (what is this?) (verify) |
Oxazolam is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a prodrug for desmethyldiazepam.[1]
See also
References
- ^ Ochs HR, Greenblatt DJ, Verburg-Ochs B, Locniskar A (October 1984). "Comparative single-dose kinetics of oxazolam, prazepam, and clorazepate: three precursors of desmethyldiazepam". J Clin Pharmacol 24 (10): 446–51. doi:10.1002/j.1552-4604.1984.tb01817.x. PMID 6150943.
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GABAA receptor positive allosteric modulators
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| Alcohols |
- Brometone
- Butanol
- Chloralodol
- Chlorobutanol (cloretone)
- Ethanol (drinking alcohol)
- Ethchlorvynol
- Isobutanol
- Isopropanol
- Menthol
- Methanol
- Methylpentynol
- Pentanol
- Petrichloral
- Propanol
- tert-Butanol (2M2P)
- tert-Pentanol (2M2B)
- Tribromoethanol
- Trichloroethanol
- Triclofos
- Trifluoroethanol
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| Barbiturates |
- (-)-DMBB
- Allobarbital
- Alphenal
- Amobarbital
- Aprobarbital
- Barbexaclone
- Barbital
- Benzobarbital
- Benzylbutylbarbiturate
- Brallobarbital
- Brophebarbital
- Butabarbital/Secbutabarbital
- Butalbital
- Buthalital
- Butobarbital
- Butallylonal
- Carbubarb
- CP-1414S
- Crotylbarbital
- Cyclobarbital
- Cyclopentobarbital
- Difebarbamate
- Enallylpropymal
- Ethallobarbital
- Eterobarb
- Febarbamate
- Heptabarb
- Heptobarbital
- Hexethal
- Hexobarbital
- Metharbital
- Methitural
- Methohexital
- Methylphenobarbital
- Narcobarbital
- Nealbarbital
- Pentobarbital
- Phenallymal
- Phenobarbital
- Phetharbital
- Primidone
- Probarbital
- Propallylonal
- Propylbarbital
- Proxibarbital
- Reposal
- Secobarbital
- Sigmodal
- Spirobarbital
- Talbutal
- Tetrabamate
- Tetrabarbital
- Thialbarbital
- Thiamylal
- Thiobarbital
- Thiobutabarbital
- Thiopental
- Thiotetrabarbital
- Valofane
- Vinbarbital
- Vinylbital
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| Benzodiazepines |
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| Carbamates |
- Carisbamate
- Carisoprodol
- Clocental
- Cyclarbamate
- Difebarbamate
- Emylcamate
- Ethinamate
- Febarbamate
- Felbamate
- Hexapropymate
- Lorbamate
- Mebutamate
- Meprobamate
- Nisobamate
- Pentabamate
- Phenprobamate
- Procymate
- Styramate
- Tetrabamate
- Tybamate
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| Flavonoids |
- 6-Methylapigenin
- Ampelopsin (dihydromyricetin)
- Apigenin
- Baicalein
- Baicalin
- Catechin
- EGC
- EGCG
- Hispidulin
- Linarin
- Luteolin
- Rc-OMe
- Skullcap constituents (e.g., baicalin)
- Wogonin
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| Imidazoles |
- Etomidate
- Metomidate
- Propoxate
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| Kava constituents |
- 10-Methoxyyangonin
- 11-Methoxyyangonin
- 11-Hydroxyyangonin
- Desmethoxyyangonin
- 11-Methoxy-12-hydroxydehydrokavain
- 7,8-Dihydroyangonin
- Kavain
- 5-Hydroxykavain
- 5,6-Dihydroyangonin
- 7,8-Dihydrokavain
- 5,6,7,8-Tetrahydroyangonin
- 5,6-Dehydromethysticin
- Methysticin
- 7,8-Dihydromethysticin
- Yangonin
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| Monoureides |
- Acecarbromal
- Apronal (apronalide)
- Bromisoval
- Carbromal
- Capuride
- Ectylurea
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| Neuroactive steroids |
- Acebrochol
- Allopregnanolone
- Alfadolone
- Alfaxalone
- 3α-Androstanediol
- Androstenol
- Androsterone
- Cholesterol
- DHDOC
- 3α-DHP
- 5α-DHP
- 5β-DHP
- Etiocholanolone
- Ganaxolone
- Hydroxydione
- Minaxolone
- Org 20599
- Org 21465
- Pregnanolone (eltanolone)
- Progesterone
- Renanolone
- SAGE-217
- SAGE-689
- THDOC
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| Nonbenzodiazepines |
- β-Carbolines: Abecarnil
- Gedocarnil
- Harmane
- SL-651,498
- ZK-93423; Cyclopyrrolones: Eszopiclone
- Pagoclone
- Pazinaclone
- Suproclone
- Suriclone
- Zopiclone; Imidazopyridines: Alpidem
- DS-1
- Necopidem
- Saripidem
- Zolpidem; Pyrazolopyrimidines: Divaplon
- Fasiplon
- Indiplon
- Lorediplon
- Ocinaplon
- Panadiplon
- Taniplon
- Zaleplon; Others: Adipiplon
- CGS-8216
- CGS-9896
- CGS-13767
- CGS-20625
- CL-218,872
- CP-615,003
- CTP-354
- ELB-139
- GBLD-345
- JM-1232
- L-838,417
- Lirequinil (Ro41-3696)
- NS-2664
- NS-2710
- NS-11394
- Pipequaline
- ROD-188
- RWJ-51204
- SB-205,384
- SX-3228
- TP-003
- TPA-023
- TP-13
- U-89843A
- U-90042
- Y-23684
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| Phenols |
- Fospropofol
- Propofol
- Thymol
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| Piperidinediones |
- Glutethimide
- Methyprylon
- Piperidione
- Pyrithyldione
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| Pyrazolopyridines |
- Cartazolate
- Etazolate
- ICI-190,622
- Tracazolate
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| Quinazolinones |
- Afloqualone
- Cloroqualone
- Diproqualone
- Etaqualone
- Mebroqualone
- Mecloqualone
- Methaqualone
- Methylmethaqualone
- Nitromethaqualone
- SL-164
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| Volatiles/gases |
- Acetone
- Acetophenone
- Acetylglycinamide chloral hydrate
- Aliflurane
- Benzene
- Butane
- Butylene
- Centalun
- Chloral
- Chloral betaine
- Chloral hydrate
- Chloroform
- Cryofluorane
- Desflurane
- Dichloralphenazone
- Dichloromethane
- Diethyl ether
- Enflurane
- Ethyl chloride
- Ethylene
- Fluroxene
- Gasoline
- Halopropane
- Halothane
- Isoflurane
- Kerosine
- Methoxyflurane
- Methoxypropane
- Nitric oxide
- Nitrogen
- Nitrous oxide
- Norflurane
- Paraldehyde
- Propane
- Propylene
- Roflurane
- Sevoflurane
- Synthane
- Teflurane
- Toluene
- Trichloroethane (methyl chloroform)
- Trichloroethylene
- Vinyl ether
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| Others/unsorted |
- 3-Hydroxybutanal
- α-EMTBL
- AA-29504
- Avermectins (e.g., ivermectin)
- Bromide compounds (e.g., lithium bromide, potassium bromide, sodium bromide)
- Carbamazepine
- Chloralose
- Chlormezanone
- Clomethiazole
- DEABL
- Dihydroergolines (e.g., dihydroergocryptine, dihydroergosine, dihydroergotamine, ergoloid (dihydroergotoxine))
- DS2
- Efavirenz
- Etazepine
- Etifoxine
- Fenamates (e.g., flufenamic acid, mefenamic acid, niflumic acid, tolfenamic acid)
- Fluoxetine
- Flupirtine
- Hopantenic acid
- Lanthanum
- Lignans (e.g., 4-O-methylhonokiol, honokiol, magnolol, obovatol)
- Loreclezole
- Menthyl isovalerate (validolum)
- Monastrol
- Niacin
- Nicotinamide (niacinamide)
- Org 25,435
- Phenytoin
- Propanidid
- Retigabine (ezogabine)
- Safranal
- SAGE-547
- Seproxetine
- Stiripentol
- Sulfonylalkanes (e.g., sulfonmethane (sulfonal), tetronal, trional)
- Terpenoids (e.g., borneol)
- Topiramate
- Valerian constituents (e.g., isovaleric acid, isovaleramide, valerenic acid, valerenol)
- Unsorted benzodiazepine site PAMs: MRK-409 (MK-0343)
- TCS-1105
- TCS-1205
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See also: GABAergics
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English Journal
- Utilization of psychotropic drugs in Taiwan: an overview of outpatient sector in 2000.
- Su TP1, Chen TJ, Hwang SJ, Chou LF, Fan AP, Chen YC.
- Zhonghua yi xue za zhi = Chinese medical journal; Free China ed.Zhonghua Yi Xue Za Zhi (Taipei).2002 Aug;65(8):378-91.
- BACKGROUND: Development of pharmacological treatment in mental disorders has risen drastically over the past decade in Taiwan. We performed a survey of the National Health Insurance claims for outpatient psychiatric services to study the utilization of psychotropic drugs. The analysis followed the d
- PMID 12455808
- Screening and determination of benzodiazepines in whole blood using solid-phase extraction and gas chromatography/mass spectrometry.
- Inoue H1, Maeno Y, Iwasa M, Matoba R, Nagao M.
- Forensic science international.Forensic Sci Int.2000 Sep 11;113(1-3):367-73.
- Benzodiazepines are one of the most widely prescribed drugs for the treatment of a wide spectrum of clinical disorders. They are used as anticonvulsants, anxiolytics, hypnotics or muscle relaxants with different duration of action. In this paper, a simple and sensitive method for the determination o
- PMID 10978650
- Solid-phase microextraction and GC-ECD of benzophenones for detection of benzodiazepines in urine.
- Guan F1, Seno H, Ishii A, Watanabe K, Kumazawa T, Hattori H, Suzuki O.
- Journal of analytical toxicology.J Anal Toxicol.1999 Jan-Feb;23(1):54-61.
- Benzodiazepines are common drugs that cause intoxication. Benzodiazepines and their metabolites can be converted by hydrolysis in acid to the corresponding benzophenones, which are easier to be separated from matrices because of their hydrophobic properties. In this study, a new separation technique
- PMID 10022210
Japanese Journal
- Effects of Tandospirone Citrate and Oxazolam on Pharmacokinetics of Valproic Acid Following Oral Administration of Sodium Valproate to Rats
- Hobara Norio,Kameya Hiromasa,Hokama Nobuo,Ohshiro Susumu,Hobara Narumi,Sakanashi Matao
- 医療薬学 33(6), 496-501, 2007-06-10
- … The drug interactions between tandospirone citrate, a non-benzodiazepine antianxiety drug, and oxazolam, a minor benzodiazepine tranquilizer and antianxiety agent, and valpronic acid (VPA), an anti-convulsant, were studied in rats. … However, when tandospirone citrate was administered intraperitonally, or both it and oxazolam were administered orally with VPA-Na, the VPA pharmacokinetic parameters were unchanged. …
- NAID 110006290466
- Simultaneous Analysis of Seven Benzodiazepines in Dietary Supplements as Adulterants Using High Performance Liquid Chromatography and its Application to an Identification System for Diazepam
- Mikami Eiichi,Goto Tomomi,Ohno Tsutomu [他],Oka Hisao,Kanamori Hisayuki
- Journal of health science 51(3), 278-283, 2005-06-01
- … A high performance liquid chromatography (HPLC) method for the simultaneous analysis of the seven benzo-diazepines (BZDs), oxazolam, nitrazepam, oxazepam, tofisopam, triazolam, clotiazepam and diazepam (DIA) is presented for application in the screening examination of dietary supplements as adulterants. …
- NAID 10016657405
- 釣藤散, メリスロン^<【○!R】>, セレナール^<【○!R】> による耳鳴治療
- 西岡 慶子,松岡 寿子,西岡 滋子 [他],山本 眞美,一原 直人,一原 由美子
- 耳鼻咽喉科臨床 95(4), 413-420, 2002-04-01
- … Forty-two patients complaining of tinnitus were treated orally with Choto-san (a Chinese medicine), Betahistine Mesilate, and Oxazolam for one month. …
- NAID 10008099741
Related Links
- オキサゾラム (oxazolam) はベンゾジアゼピン系の抗不安薬の一種。長時間作用型。 心身症からくる不安・緊張・抑うつ・睡眠障害および、パニック障害、自律神経失調症 などに適応がある。日本での商品名はセレナールなど。
- Oxazolam is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a prodrug for desmethyldiazepam.
Related Pictures
★リンクテーブル★
[★]
- 英
- oxazolam
- 同
- オキサゾラゼパム oxazolazepam
- 商
- セレナール、ペルサール