未分化胚細胞腫
WordNet
- of or involving the ovaries; "ovarian cancer"
- malignant tumor of the testis; usually occurring in older men (同)testicular_cancer
PrepTutorEJDIC
- 卵巣の / 子房(しぼう)の
UpToDate Contents
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English Journal
- Identification and characterization of 2 testicular germ cell markers, Glut3 and CyclinA2.
- Howitt BE, Brooks JD, Jones S, Higgins JP.Author information Departments of *Pathology †Urology, Stanford University School of Medicine, Stanford, CA.AbstractTesticular germ cell tumors (TGCT) are the most common type of testicular tumor and encompass different histologic types that greatly influence treatment and prognosis. Immunohistochemical studies may be required for accurate classification, particularly when these tumors present at extragonadal sites, and to aid in distinguishing histologic types. Traditional markers for identifying and distinguishing TGCT include PLAP, CD117, AFP, and CD30. More recently, the addition of OCT3/4 and SALL4 has increased sensitivity for immunohistochemical detection of germ cell tumors. We examined gene expression data from a previously published microarray study that compared normal testis mRNA expression to various TGCT. We also performed a search of the literature to identify less well-characterized markers. Glut3 and cyclinA2 showed promise as TGCT markers. Therefore, we evaluated expression of glut3 and cyclinA2 by immunohistochemistry using tissue microarrays (TMAs). Of 66 seminomas included in the TMA, 64 (97%) showed positive nuclear staining for cyclinA2 and 58 (88%) were strongly positive. Strong positive staining for cyclinA2 was also seen in the spermatocytic seminoma. All 20 of the embryonal carcinomas stained positively with cyclinA2, and 19 (95%) displayed strong nuclear staining for cyclinA2. Twenty of the 20 embryonal carcinomas stained for glut3 in a strong membranous pattern. Of 8 yolk sac tumors, 100% stained with glut3. We also evaluated glut3 and cyclinA2 staining on a general TMA containing 486 samples representing 156 different tumors. CyclinA2 stained a number of other tumor types, but the majority of these were weak or focal staining. Glut3 was rarely positive in other tumors; interestingly, most of these were of ovarian origin. We conclude that glut3 is a sensitive (96%) and specific (92%) marker for embryonal carcinomas and yolk sac tumors. Although cyclinA2 is a sensitive marker of seminomas and embryonal carcinomas (98%), its specificity is lower if focal and weak staining of nongerm cell tumors is considered positive. The sensitivity and specificity of glut3 are comparable with that seen for SALL4.
- Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry.Appl Immunohistochem Mol Morphol.2013 Oct;21(5):401-7. doi: 10.1097/PAI.0b013e31827b505f.
- Testicular germ cell tumors (TGCT) are the most common type of testicular tumor and encompass different histologic types that greatly influence treatment and prognosis. Immunohistochemical studies may be required for accurate classification, particularly when these tumors present at extragonadal sit
- PMID 23343953
- Have you had your pet spayed or neutered?
- Webb JL, Friedrichs KR.
- Veterinary clinical pathology / American Society for Veterinary Clinical Pathology.Vet Clin Pathol.2013 Mar;42(1):3. doi: 10.1111/vcp.12027.
- PMID 23458654
- Heterozygote FANCD2 mutations associated with childhood T Cell ALL and testicular seminoma.
- Smetsers S, Muter J, Bristow C, Patel L, Chandler K, Bonney D, Wynn RF, Whetton AD, Will AM, Rockx D, Joenje H, Strathdee G, Shanks J, Klopocki E, Gille JJ, Dorsman J, Meyer S.Author information Department of Clinical Genetics and Human Genetics, University Medical Centre, Free University of Amsterdam, Amsterdam, The Netherlands.AbstractFanconi anaemia (FA) is an inherited disease with congenital and developmental abnormalities characterised by cellular cross linker hypersensitivity. FA is caused by mutations in any of so far 15 identified FANC genes, which encode proteins that interact in a common DNA damage response (DDR) pathway. Individuals with FA have a high risk of developing acute myeloid leukaemia (AML) and squamous cell carcinoma. An increased cancer risk has been firmly established for carriers of mutations in FANCD1/BRCA2, FANCJ/BRIP1, FANCN/PALB2, RAD51C/FANCO and link the FA pathway to inherited breast and ovarian cancer. We describe a pedigree with FANCD2 mutations c.458T > C (p.Leu153Ser) and c.2715 + 1G > A (p.Glu906LeufsX4) with mild phenotype FA in the index case, T cell ALL in the Leu153Ser heterozygous brother and testicular seminoma in the p.Glu906LeufsX4 heterozygous father. Both FANCD2 alleles were present in the T Cell ALL and the seminoma. This links specific FANCD2 mutations to T cell ALL and seminoma without evidence of allelic loss in the tumour tissue.
- Familial cancer.Fam Cancer.2012 Dec;11(4):661-5. doi: 10.1007/s10689-012-9553-3.
- Fanconi anaemia (FA) is an inherited disease with congenital and developmental abnormalities characterised by cellular cross linker hypersensitivity. FA is caused by mutations in any of so far 15 identified FANC genes, which encode proteins that interact in a common DNA damage response (DDR) pathway
- PMID 22829014
Japanese Journal
- セミノーマの発症を契機に診断された精巣性女性化症候群の1例
- 井上 信行,古谷 知子,木下 幸正,大泉 えり子,前田 智治,古谷 敬三,岡本 賢二郎
- 日本臨床細胞学会雑誌 44(2), 84-87, 2005-03-22
- NAID 10015546639
- WIDESPREAD DISTRIBUTION OF HUMAN EPIDERMAL GROWTH FACTOR (hEGF) IN HUMAN TISSUES AND ORGANS UNDER NORMAL AND TUMOROUS CONDITIONS : IMMUNO-HISTOCHEMICAL STUDIES WITH THE USE OF POLYCLONAL AND MONOCLONAL ANTIBODIES
- MORI MASAHIKO,NAITO RYOJI,TSUKITANI KOUJI,OKADA YUKIO,TSUJIMURA TAKAHIRO
- Acta Histochemica et Cytochemica 22(1), 15-34, 1989
- … also found comparatively intense hEGF staining in the epithelial components of various neoplastic lesions, such as salivary plemorphic adenoma, gastric cancer, pancreatic adenocarcinoma, epithelial tumor cells in Wilms tumor, ovarian adenocarcinoma, adenomatous cells of hypertrophied prostate, seminoma and embryonal carcinoma in the testis, decidual cells of hydatidiform mole, mammary adenocarcinoma, oxyphilic adenoma and follicular adenoma in the thyroid, oxyphilic cells of parathyroid adenoma, compact cells of adrenocortical …
- NAID 110003150484
- 亜急性小脳変性症を伴ったHCG-β: 陽性セミノーマの1例
- 小川 修,橋本 京子,谷口 隆信,中川 隆,日下 博文,高橋 良輔,松本 禎之,今井 輝国
- 泌尿器科紀要 33(12), 2134-2140, 1987-12
- … There have been several reports of subacute cerebellar degeneration in lung carcinoma, ovarian carcinoma and Hodgkin's disease, but rare in urogenital malignancies. … We present a patient with neurological disorder considered subacute cerebellar degeneration associated with HCG-beta positive seminoma. … Left high orchiectomy was performed and the tumor was diagnosed histologically as typical seminoma. …
- NAID 120002159774
★リンクテーブル★
[★]
- 英
- dysgerminoma
- 同
- ジスジャーミノーマ、卵巣精上皮腫 ovarian seminoma
- 関
- セミノーマ
後発部位
- 精巣のセミノーマ seminomaに相当する
- 両側性(5-10%, 10-20%(APT.323)) ← 悪性肺細胞腫瘍の中で唯一両側発生傾向があるらしい
- 放射線感受性あり
疫学
- 若い女性に多い。妊娠に合併しうる
- 20-30歳代80%。10歳未満5% (also see APT.323
病理
- This neoplasm is composed of sheets and cords of large polyhedral cells with large nuclei and pale pink to watery cytoplasm. (APT.323)
- hCGを産生する栄養膜合胞体細胞(syncytiotrophoblastic cell)が存在することがある。
転移
[★]
- 関
- ovary