Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/20 09:11:29」(JST)

wiki en

Orosomucoid (ORM) or alpha-1-acid glycoprotein (α₁AGp,^[1] AGP or AAG) is an acute phase (acute phase protein) plasma alpha-globulin glycoprotein and is modulated by two polymorphic genes. It is synthesized primarily in hepatocytes and has a normal plasma concentration between 0.6-1.2 mg/mL (1-3% plasma protein).^[2] Plasma levels are affected by pregnancy, certain drugs, and certain diseases, particularly HIV.^[2]

The only established function of ORM is to act as a carrier of basic and neutrally charged lipophilic compounds. In medicine, it is known as the primary carrier of acidic (negatively charged) drugs (whereas albumin carries basic (positively charged) drugs), steroids, and protease inhibitors.^[2]^[3] Aging causes a small decrease in plasma albumin levels; if anything, there is a small increase in alpha-1-acid glycoprotein. The effect of these changes on drug protein binding and drug delivery, however, appear to be minimal.^[4]

Alpha-1-acid glycoprotein has been identified as one of four potentially useful circulating biomarkers for estimating the five-year risk of all-cause mortality (the other three are albumin, very low-density lipoprotein particle size, and citrate).^[5]

Orosomucoid increases in amount in obstructive jaundices while diminishes in hepatocellular jaundice and in intestinal infections.

References

^ Logan, Carolynn M.; Rice, M. Katherine (1987). Logan's Medical and Scientific Abbreviations. Philadelphia: J. B. Lippincott Company. p. 3. ISBN 0-397-54589-4.
^ ^a ^b ^c Colombo S, Buclin T, Décosterd LA, Telenti A, Furrer H, Lee BL, Biollaz J, Eap CB (2006). "Orosomucoid (alpha1-acid glycoprotein) plasma concentration and genetic variants: effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation". Clin. Pharmacol. Ther. 80 (4): 307–18. doi:10.1016/j.clpt.2006.06.006. PMID 17015049.
^ Urien S, Brée F, Testa B, Tillement JP (1991). "pH-dependency of basic ligand binding to alpha 1-acid glycoprotein (orosomucoid)". Biochem. J. 280 (1): 277–80. PMC 1130632. PMID 1741754.
^ Barash, Paul G. (2009). Clinical Anesthesia. p. 879.
^ Fischer, Kettunen, Würtz, et al. "Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons.". PLoS Medicine 11(2): e1001606. doi:10.1371/journal.pmed.1001606.

External links

Orosomucoid at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on chromosome 9 is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 新生児における壊死性腸炎の臨床的特徴および診断 clinical features and diagnosis of necrotizing enterocolitis in newborns
2. Mercury toxicity

English Journal

Serum S100A12 (EN-RAGE) Levels in Patients with Decreased Renal Function and Subclinical Chronic Inflammatory Disease.

Zakiyanov O, Kalousova M, K?iha V, Zima T, Tesa? V.SourceDepartment of Nephrology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Czech Republic.
Kidney & blood pressure research.Kidney Blood Press Res.2011 Aug 5;34(6):457-464. [Epub ahead of print]
Background: The calcium-binding protein S100A12 (EN-RAGE) causes inflammation through interaction with the multiligand receptor for advanced glycation end products (RAGE). The aim of the study was to determine S100A12 levels and describe their relationship to inflammatory markers in patients with de
PMID 21822023

Effects of surgery and chronic disease states on the concentrations and phenotype distribution of α1-acid glycoprotein: studies in patients with breast cancer and patients with chronic inflammatory disease.

Hanada K, Yamanaka E, Yamamoto N, Minami H, Kawai S, Sasaki Y, Ogata H.SourceDepartment of Biopharmaceutics, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan. hanada@my-pharm.ac.jp
International journal of clinical pharmacology and therapeutics.Int J Clin Pharmacol Ther.2011 Jul;49(7):415-21.
OBJECTIVE: Although the concentration of α1-acid glycoprotein (AGP) in serum increases under some conditions, the behavior of the individual genetic variants is not well understood. Therefore, we studied the relative changes in AGP variants pre- and postoperatively in patients with cancer and patie
PMID 21726491

Japanese Journal

Purification and Characterization of Extracellular 1,2-α-L-Fucosidase from Bacillus cereus(Enzymology, Protein Engineering, and Enzyme Technology)

MIURA TOYOKAZU,OKAMOTO KENJI,YANASE HIDESHI
Journal of bioscience and bioengineering 99(6), 629-635, 2005-06-25
… The enzyme was inactive on p-nitrophenyl α-L-fucoside, the α-(1→3)-L-fucosidic linkages in Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4Glc (lacto-N-fucopentaose III) and orosomucoid, the α-(1→4)-L-fucosidic linkage in Galβ1-3(Fucα1-4)GlcNAcβ1-3Galβ1-4Glc (lacto-N-fucopentaose II), and the α-(1→6)-L-fucosidic linkage in thyroglobulin. …
NAID 110002695712

Lectin affinity capillary electrophoresis in glycoform analysis applying the partial filling technique

BERGSTROM Maria,NILSSON Mikael,ISAKSSON Roland,RYDEN Ingvar,PAHLSSON Peter,OHLSON Sten
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 809(2), 323-329, 2004-10-05
NAID 10016556003

Related Pictures

acid glycoprotein (orosomucoid) Briskly Orosomucoid; Acid Seromucoid; alpha 1-Acid Properties of the Glomerular Barrier and orosomucoid as ovarian biomarkers a maldi orosomucoid orosomucoid orm or alpha 1 Taxol, a potent anticancer natural product Orosomucoid (Acid Seromucoid; alpha 1-Acid