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taking immediate advantage, often unethically, of any circumstance of possible benefit (同)opportunistic, timeserving
a person who places expediency above principle (同)self-seeker

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Aspartic Protease Inhibitors: Effective Drugs against the Human Fungal Pathogen Candida albicans.

Santos AL, Braga-Silva LA.SourceLaboratório de Estudos Integrados em Bioquímica Microbiana, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes (IMPG), Bloco E-subsolo, Centro de Ciências da Saúde (CCS), Universidade Federal do Rio de Janeiro (UFRJ), Av. Carlos Chagas Filho, 373, Cidade Universitária, Rio de Janeiro, RJ 21941-902, Brazil. andre@micro.ufrj.br, alsouzasantos@gmail.com.
Mini reviews in medicinal chemistry.Mini Rev Med Chem.2012 Dec 5. [Epub ahead of print]
Candida albicans can invade humans and may lead to mucosal and skin infections or to deep-seated mycoses of almost all inner organs, especially in immunocompromised patients. In this context, both the host immune status and the ability of C. albicans to modulate the expression of its virulence facto
PMID 23256485

Rodríguez-Cerdeira C, Arenas R, Moreno-Coutiño G, Vásquez E, Fernández R, Chang P.SourceServicio de Dermatología, CHUVI y Universidad de Vigo, Vigo, España. Electronic address: carmen.rodriguez.cerdeira@sergas.es.
Actas dermo-sifiliograficas.Actas Dermosifiliogr.2012 Oct 26. pii: S0001-7310(12)00417-6. doi: 10.1016/j.ad.2012.06.017. [Epub ahead of print]
Histoplasmosis is a systemic infection caused by the dimorphic fungus Histoplasma capsulatum. In immunocompromised patients, primary pulmonary infection can spread to the skin and meninges. Clinical manifestations appear in patients with a CD4(+) lymphocyte count of less than 150 cells/μL. Coccidio
PMID 23107866

Cryptococcus neoformans activates RhoGTPase proteins followed by protein kinase C, focal adhesion kinase, and ezrin to promote traversal across the blood-brain barrier.

Kim JC, Crary B, Chang YC, Kwon-Chung KJ, Kim KJ.SourceDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
The Journal of biological chemistry.J Biol Chem.2012 Oct 19;287(43):36147-57. doi: 10.1074/jbc.M112.389676. Epub 2012 Aug 16.
Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis. Previous studies have demonstrated that Cryptococcus binding and invasion of human brain microvascular endothelial cells (HBMEC) is a prerequisite for transmigration across the blood-brain barrier. However,
PMID 22898813

竹中賢,花桐武志,岡壮一 [他],馬場哲郎,安田学,小野憲司,浦本秀隆,宗知子,竹之山光広,山田壮亮,安元公正
産業医科大学雑誌 32(3), 237-243, 2010-09-01
肺クリプトコックス症は,Cryptococcus neoformansが吸入されることによって生じる肺真菌症であり,免疫能が低下した易感染性宿主に発生する日和見感染症とされるが,健常人における罹患も知られており,近年では健康診断および他疾患精査中などで偶然発見されることが増加している.今回,外科治療を施行した肺クリプトコックス症8例について検討した.年齢は49歳から85歳,男性4例,女性4例であっ …
NAID 110007700769

國武泰史,有永照子,緒方啓 [他],井出達也,宮島一郎,垣内誠也,久原孝一郎,桑原礼一郎,古賀郁利子,鳥村拓司,神代龍吉,佐田通夫
肝臓 51(1), 13-20, 2010-01-25
症例は72歳男性．肝機能障害を指摘され当科紹介受診．腹部エコー検査にて少量の腹水と慢性肝炎の所見を認め，IgG 4,984 mg/dl，抗核抗体40,960倍であり自己免疫性肝炎（AIH）を疑い精査加療のため入院となった．多彩な免疫異常を伴った重症のAIHと診断し，ステロイドパルス療法を開始した．その後，プレドニゾロン（PSL）50 mgに変更し，肝機能，プロトロンビン時間の改善がみられPSLを漸 …
NAID 10026101079

白鳥美里,石井耕司,高山竜司 [他],金山政洋,樋上勝也,篠原美絵,宮崎泰斗,吉澤定子,坪田貴也,本多満,吉原克則,住野泰清
肝臓 50(12), 711-718, 2009-12-25
症例は66歳女性．全身倦怠感を主訴に近医を受診し，急性B型肝炎重症型と診断され当院に紹介入院となった．第2病日目には脳症II度となり，劇症肝炎急性型と診断した．人工肝補助，抗ウイルス療法やステロイドパルス療法などの集中治療が奏効し肝炎は改善した．しかし，淡い多発性の斑状陰影が両肺にみられ，右腎の腫瘤像も増大するため，腎腫瘤をドレナージ目的で穿刺したところ，アスペルギルスが検出され，侵襲性肺アスペル …
NAID 10026100923