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English Journal

Retinoblastoma-binding Protein 4-regulated Classical Nuclear Transport Is Involved in Cellular Senescence.

Tsujii A1, Miyamoto Y2, Moriyama T2, Tsuchiya Y3, Obuse C4, Mizuguchi K3, Oka M5, Yoneda Y6.
The Journal of biological chemistry.J Biol Chem.2015 Dec 4;290(49):29375-88. doi: 10.1074/jbc.M115.681908. Epub 2015 Oct 21.
Nucleocytoplasmic trafficking is a fundamental cellular process in eukaryotic cells. Here, we demonstrated that retinoblastoma-binding protein 4 (RBBP4) functions as a novel regulatory factor to increase the efficiency of importin α/β-mediated nuclear import. RBBP4 accelerates the release of impor
PMID 26491019

O-GlcNAcomic Profiling Identifies Widespread O-Linked β-N-Acetylglucosamine Modification (O-GlcNAcylation) in Oxidative Phosphorylation System Regulating Cardiac Mitochondrial Function.

Ma J1, Liu T2, Wei AC2, Banerjee P1, O'Rourke B2, Hart GW3.
The Journal of biological chemistry.J Biol Chem.2015 Dec 4;290(49):29141-53. doi: 10.1074/jbc.M115.691741. Epub 2015 Oct 7.
Dynamic cycling of O-linked β-N-acetylglucosamine (O-GlcNAc) on nucleocytoplasmic proteins serves as a nutrient sensor to regulate numerous biological processes. However, mitochondrial protein O-GlcNAcylation and its effects on function are largely unexplored. In this study, we performed a comparat
PMID 26446791

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.

Mertens J1, Paquola AC1, Ku M2, Hatch E3, Böhnke L1, Ladjevardi S1, McGrath S1, Campbell B1, Lee H1, Herdy JR1, Gonçalves JT1, Toda T1, Kim Y1, Winkler J4, Yao J5, Hetzer MW3, Gage FH6.
Cell stem cell.Cell Stem Cell.2015 Dec 3;17(6):705-18. doi: 10.1016/j.stem.2015.09.001. Epub 2015 Oct 8.
Aging is a major risk factor for many human diseases, and in vitro generation of human neurons is an attractive approach for modeling aging-related brain disorders. However, modeling aging in differentiated human neurons has proved challenging. We generated neurons from human donors across a broad
PMID 26456686