WordNet

used to express refusal or denial or disagreement etc or especially to emphasize a negative statement; "no, you are wrong"
a negative; "his no was loud and clear"
referring to the degree to which a certain quality is present; "he was no heavier than a child" (同)no more
not in any degree or manner; not at all; "he is no better today"
quantifier; used with either mass nouns or plural count nouns for indicating a complete or almost complete lack or zero quantity of; "we have no bananas"; "no eggs left and no money to buy any"; "have you no decency?"; "did it with no help"; "Ill get you there in no time"

PrepTutorEJDIC

《名詞の前に置いて》『一つも』(『一人も,少しも』)・・・『ない』 / 《補語につけて》『決して・・・でない』 / 《省略文で》・・・なし;・・・お断り / 《話》少ししか(あまり)・・・ない / (肯定の問いに対して)『いいえ』;(否定の問いに対して)はい,ええ / 《not, norの前に挿入して》『いや』,否 / 《形容詞の前に置その形容詞を否定して》…どころではない / 《比較級の前に置いて》ちっとも…でない,…と全く同じ / 《… or no の形で》…であってもなくても / 《驚き・困惑・不信などを表して》とんでもない / 《単数形で》『拒否』,「『いいえ』」という返事 / 《複数形で》反対[投]票

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/12/16 13:28:33」(JST)

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[Wiki en表示]

Phorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the PMAIP1 gene, and is also known as Noxa.^[2]^[3]^[4]

Noxa (Latin for damage) is a pro-apoptotic member of the Bcl-2 protein family.^[5] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor p53, and Noxa has been shown to be involved in p53-mediated apoptosis.

Interactions

Noxa has been shown to interact with:

BCL2-like 1,^[6]^[7]
Bcl-2,^[6]^[7] and
MCL1.^[6]^[8]

References

^ "Human PubMed Reference:".
^ Hijikata M, Kato N, Sato T, Kagami Y, Shimotohno K (October 1990). "Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line". J Virol. 64 (10): 4632–9. PMC 247947. PMID 2398525.
^ Jansson AK, Emterling AM, Arbman G, Sun XF (July 2003). "Noxa in colorectal cancer: a study on DNA, mRNA and protein expression". Oncogene. 22 (30): 4675–8. doi:10.1038/sj.onc.1206655. PMID 12879012.
^ "Entrez Gene: PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1".
^ Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science. 288 (5468): 1053–1058. doi:10.1126/science.288.5468.1053. PMID 10807576.
^ ^a ^b ^c Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (February 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell. 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340.
^ ^a ^b Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (May 2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis". Science. 288 (5468): 1053–8. doi:10.1126/science.288.5468.1053. PMID 10807576.
^ Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC (June 2005). "Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins". Genes Dev. 19 (11): 1294–305. doi:10.1101/gad.1304105. PMC 1142553. PMID 15901672.

External links

NOXA protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

English Journal

A NOXA/MCL-1 Imbalance Underlies Chemoresistance of Malignant Rhabdoid Tumor Cells.

Ouchi K1, Kuwahara Y1, Iehara T1, Miyachi M1, Katsumi Y1, Tsuchiya K1, Konishi E2, Yanagisawa A2, Hosoi H1.
Journal of cellular physiology.J Cell Physiol.2016 Sep;231(9):1932-40. doi: 10.1002/jcp.25293. Epub 2016 Jan 14.
Malignant rhabdoid tumor (MRT) is a rare aggressive pediatric cancer characterized by inactivation of SNF5, a core subunit of SWI/SNF complexes. Previously, we showed that SNF5 contributes to transcriptional activation of NOXA, a pro-apoptotic protein that binds and inhibits the anti-apoptotic prote
PMID 26680268

A new semisynthetic 1-O-acetyl-6-O-lauroylbritannilactone induces apoptosis of human laryngocarcinoma cells through p53-dependent pathway.

Han YY1, Tang JJ2, Gao RF1, Guo X3, Lei M4, Gao JM3.
Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2016 Sep;35:112-20. doi: 10.1016/j.tiv.2016.05.019. Epub 2016 Jun 2.
Initiation of apoptosis is an important event for chemoprevention and chemotherapy of cancer. Naturally derived products had drawn growing attention as lead compounds for anticancer drug discovery. ABL-L, a semisynthetic analogue of natural sesquiterpenoid 1-O-acetylbritannilactone (ABL) isolated fr
PMID 27262408

Intracellular delivery of poly(I:C) induces apoptosis of fibroblast-like synoviocytes via an unknown dsRNA sensor.

Karpus ON1, Hsiao CC1, de Kort H1, Tak PP1, Hamann J2.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2016 Aug 26;477(3):343-9. doi: 10.1016/j.bbrc.2016.06.104. Epub 2016 Jun 22.
Fibroblast-like synoviocytes (FLS) express functional membranous and cytoplasmic sensors for double-stranded (ds)RNA. Notably, FLS undergo apoptosis upon transfection with the synthetic dsRNA analog poly(I:C). We here studied the mechanism of intracellular poly(I:C) recognition and subsequent cell d
PMID 27343555

Japanese Journal

Virosomeによるがん治療法の開発と臨床応用

日本薬理学雑誌 147(6), 330-333, 2016
NAID 130005156512

A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation

Scientific Reports 5, 18231, 2015-12-15
NAID 120005828844

Gene Expression Profiles in the Fetal Mouse Brain after Etoposide (VP-16) Administration

Experimental animals 62(2), 93-99, 2013-04-01
NAID 10031163548

「病毒」

PMAIP1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3MQP
Identifiers
Aliases	PMAIP1, APR, NOXA, phorbol-12-myristate-13-acetate-induced protein 1
External IDs	OMIM: 604959 HomoloGene: 88883 GeneCards: PMAIP1
Gene ontology
Molecular function	• protein binding;
Cellular component	• cytosol; • mitochondrial outer membrane; • mitochondrion; • nucleus;
Biological process	• positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; • response to dsRNA; • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; • cellular response to glucose starvation; • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; • negative regulation of mitochondrial membrane potential; • positive regulation of glucose metabolic process; • reactive oxygen species metabolic process; • cellular response to DNA damage stimulus; • T cell homeostasis; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; • positive regulation of neuron apoptotic process; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • regulation of mitochondrial membrane permeability; • defense response to virus; • intrinsic apoptotic signaling pathway by p53 class mediator; • intrinsic apoptotic signaling pathway in response to DNA damage; • positive regulation of protein oligomerization; • positive regulation of apoptotic process; • positive regulation of release of cytochrome c from mitochondria; • proteasomal protein catabolic process; • positive regulation of DNA damage response, signal transduction by p53 class mediator; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • negative regulation of fibroblast proliferation; • positive regulation of intrinsic apoptotic signaling pathway; • response to UV; • cellular response to hypoxia; • response to X-ray; • release of cytochrome c from mitochondria; • intrinsic apoptotic signaling pathway; • apoptotic process; • regulation of apoptotic process; • protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;
	Sources:Amigo / QuickGO
RNA expression pattern
	; ;
	More reference expression data
Orthologs
	5366
	n/a
	ENSG00000141682
	n/a
	Q13794
	n/a
	NM_021127
	n/a
	NP_066950.1
	n/a
	Wikidata
View/Edit Human