noxa

• 病原性毒素、病毒

関

noxae

WordNet

1. used to express refusal or denial or disagreement etc or especially to emphasize a negative statement; "no, you are wrong"
2. a negative; "his no was loud and clear"
3. referring to the degree to which a certain quality is present; "he was no heavier than a child" (同)no more
4. not in any degree or manner; not at all; "he is no better today"
5. quantifier; used with either mass nouns or plural count nouns for indicating a complete or almost complete lack or zero quantity of; "we have no bananas"; "no eggs left and no money to buy any"; "have you no decency?"; "did it with no help"; "Ill get you there in no time"

PrepTutorEJDIC

1. 《名詞の前に置いて》『一つも』(『一人も,少しも』)・・・『ない』 / 《補語につけて》『決して・・・でない』 / 《省略文で》・・・なし;・・・お断り / 《話》少ししか(あまり)・・・ない / (肯定の問いに対して)『いいえ』;(否定の問いに対して)はい,ええ / 《not, norの前に挿入して》『いや』,否 / 《形容詞の前に置その形容詞を否定して》…どころではない / 《比較級の前に置いて》ちっとも…でない,…と全く同じ / 《… or no の形で》…であってもなくても / 《驚き・困惑・不信などを表して》とんでもない / 《単数形で》『拒否』,「『いいえ』」という返事 / 《複数形で》反対[投]票

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/12/16 13:28:33」(JST)

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[Wiki en表示]

PMAIP1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3MQP
Identifiers
Aliases	PMAIP1, APR, NOXA, phorbol-12-myristate-13-acetate-induced protein 1
External IDs	OMIM: 604959 HomoloGene: 88883 GeneCards: PMAIP1
Gene ontology Molecular function • protein binding Cellular component • cytosol • mitochondrial outer membrane • mitochondrion • nucleus Biological process • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors • response to dsRNA • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • cellular response to glucose starvation • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • negative regulation of mitochondrial membrane potential • positive regulation of glucose metabolic process • reactive oxygen species metabolic process • cellular response to DNA damage stimulus • T cell homeostasis • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of neuron apoptotic process • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • regulation of mitochondrial membrane permeability • defense response to virus • intrinsic apoptotic signaling pathway by p53 class mediator • intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of protein oligomerization • positive regulation of apoptotic process • positive regulation of release of cytochrome c from mitochondria • proteasomal protein catabolic process • positive regulation of DNA damage response, signal transduction by p53 class mediator • activation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of fibroblast proliferation • positive regulation of intrinsic apoptotic signaling pathway • response to UV • cellular response to hypoxia • response to X-ray • release of cytochrome c from mitochondria • intrinsic apoptotic signaling pathway • apoptotic process • regulation of apoptotic process • protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5366	n/a
Ensembl	ENSG00000141682	n/a
UniProt	Q13794	n/a
RefSeq (mRNA)	NM_021127	n/a
RefSeq (protein)	NP_066950.1	n/a
Location (UCSC)	Chr 18: 59.9 – 59.9 Mb	n/a
PubMed search		n/a
Wikidata
View/Edit Human

Phorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the PMAIP1 gene, and is also known as Noxa.

Noxa (Latin for damage) is a pro-apoptotic member of the Bcl-2 protein family. Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of Noxa is regulated by the tumor suppressor p53, and Noxa has been shown to be involved in p53-mediated apoptosis.

Interactions

Noxa has been shown to interact with:

• BCL2-like 1,
• Bcl-2, and
• MCL1.

See also

• Apoptosis
• Apoptosome
• Bcl-2
• Bcl-2-associated X protein (BAX)
• BH3 interacting domain death agonist (BID)
• Caspases
• Cytochrome c
• Mitochondrion
• p53 upregulated modulator of apoptosis (PUMA)
• 12-O-Tetradecanoylphorbol-13-acetate (Phorbol-12-myristate-13-acetate)

References

Further reading

• Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N (2000). "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.". Science. 288 (5468): 1053–8. doi:10.1126/science.288.5468.1053. PMID 10807576. 
• Seo YW, Shin JN, Ko KH, Cha JH, Park JY, Lee BR, Yun CW, Kim YM, Seol DW, Kim DW, Yin XM, Kim TH (2004). "The molecular mechanism of Noxa-induced mitochondrial dysfunction in p53-mediated cell death.". J. Biol. Chem. 278 (48): 48292–9. doi:10.1074/jbc.M308785200. PMID 14500711. 
• Kim JY, Ahn HJ, Ryu JH, Suk K, Park JH (2004). "BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha.". J. Exp. Med. 199 (1): 113–24. doi:10.1084/jem.20030613. PMC 1887730. PMID 14699081. 
• Yakovlev AG, Di Giovanni S, Wang G, Liu W, Stoica B, Faden AI (2004). "BOK and NOXA are essential mediators of p53-dependent apoptosis.". J. Biol. Chem. 279 (27): 28367–74. doi:10.1074/jbc.M313526200. PMID 15102863. 
• Qin JZ, Stennett L, Bacon P, Bodner B, Hendrix MJ, Seftor RE, Seftor EA, Margaryan NV, Pollock PM, Curtis A, Trent JM, Bennett F, Miele L, Nickoloff BJ (2005). "p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas.". Mol. Cancer Ther. 3 (8): 895–902. PMID 15299072. 
• Flinterman M, Guelen L, Ezzati-Nik S, Killick R, Melino G, Tominaga K, Mymryk JS, Gäken J, Tavassoli M (2005). "E1A activates transcription of p73 and Noxa to induce apoptosis.". J. Biol. Chem. 280 (7): 5945–59. doi:10.1074/jbc.M406661200. PMID 15572378. 
• Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.". Mol. Cell. 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340. 
• Sun Y, Leaman DW (2005). "Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection.". J. Biol. Chem. 280 (16): 15561–8. doi:10.1074/jbc.M412630200. PMID 15705586. 
• Ceballos E, Muñoz-Alonso MJ, Berwanger B, Acosta JC, Hernández R, Krause M, Hartmann O, Eilers M, León J (2005). "Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes.". Oncogene. 24 (28): 4559–71. doi:10.1038/sj.onc.1208652. PMID 15856024. 
• Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC (2005). "Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.". Genes Dev. 19 (11): 1294–305. doi:10.1101/gad.1304105. PMC 1142553. PMID 15901672. 
• Alves NL, Derks IA, Berk E, Spijker R, van Lier RA, Eldering E (2006). "The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells.". Immunity. 24 (6): 703–16. doi:10.1016/j.immuni.2006.03.018. PMID 16782027. 
• Obexer P, Geiger K, Ambros PF, Meister B, Ausserlechner MJ (2007). "FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells.". Cell Death Differ. 14 (3): 534–47. doi:10.1038/sj.cdd.4402017. PMID 16888645. 
• Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H, Hale TJ, Soengas MS, Kaufman RJ, Wang CY (2006). "Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa.". J. Biol. Chem. 281 (42): 31440–7. doi:10.1074/jbc.M604356200. PMID 16928686. 
• Smit LA, Hallaert DY, Spijker R, de Goeij B, Jaspers A, Kater AP, van Oers MH, van Noesel CJ, Eldering E (2007). "Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity.". Blood. 109 (4): 1660–8. doi:10.1182/blood-2006-05-021683. PMID 17038534. 
• Armstrong JL, Veal GJ, Redfern CP, Lovat PE (2007). "Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours.". Apoptosis. 12 (3): 613–22. doi:10.1007/s10495-006-0020-1. PMID 17216584. 

External links

• NOXA protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

English Journal

• A NOXA/MCL-1 Imbalance Underlies Chemoresistance of Malignant Rhabdoid Tumor Cells.

• Ouchi K1, Kuwahara Y1, Iehara T1, Miyachi M1, Katsumi Y1, Tsuchiya K1, Konishi E2, Yanagisawa A2, Hosoi H1.
• Journal of cellular physiology.J Cell Physiol.2016 Sep;231(9):1932-40. doi: 10.1002/jcp.25293. Epub 2016 Jan 14.
• Malignant rhabdoid tumor (MRT) is a rare aggressive pediatric cancer characterized by inactivation of SNF5, a core subunit of SWI/SNF complexes. Previously, we showed that SNF5 contributes to transcriptional activation of NOXA, a pro-apoptotic protein that binds and inhibits the anti-apoptotic prote
• PMID 26680268

• A new semisynthetic 1-O-acetyl-6-O-lauroylbritannilactone induces apoptosis of human laryngocarcinoma cells through p53-dependent pathway.

• Han YY1, Tang JJ2, Gao RF1, Guo X3, Lei M4, Gao JM3.
• Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2016 Sep;35:112-20. doi: 10.1016/j.tiv.2016.05.019. Epub 2016 Jun 2.
• Initiation of apoptosis is an important event for chemoprevention and chemotherapy of cancer. Naturally derived products had drawn growing attention as lead compounds for anticancer drug discovery. ABL-L, a semisynthetic analogue of natural sesquiterpenoid 1-O-acetylbritannilactone (ABL) isolated fr
• PMID 27262408

• Intracellular delivery of poly(I:C) induces apoptosis of fibroblast-like synoviocytes via an unknown dsRNA sensor.

• Karpus ON1, Hsiao CC1, de Kort H1, Tak PP1, Hamann J2.
• Biochemical and biophysical research communications.Biochem Biophys Res Commun.2016 Aug 26;477(3):343-9. doi: 10.1016/j.bbrc.2016.06.104. Epub 2016 Jun 22.
• Fibroblast-like synoviocytes (FLS) express functional membranous and cytoplasmic sensors for double-stranded (ds)RNA. Notably, FLS undergo apoptosis upon transfection with the synthetic dsRNA analog poly(I:C). We here studied the mechanism of intracellular poly(I:C) recognition and subsequent cell d
• PMID 27343555

Japanese Journal

• Virosomeによるがん治療法の開発と臨床応用

• 日本薬理学雑誌 147(6), 330-333, 2016
• NAID 130005156512

• A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation

• Scientific Reports 5, 18231, 2015-12-15
• NAID 120005828844

• Gene Expression Profiles in the Fetal Mouse Brain after Etoposide (VP-16) Administration

• Experimental animals 62(2), 93-99, 2013-04-01
• NAID 10031163548

Related Links

• Noxa, a BH3-only member of the Bcl-2 family and candidate - NCBI

Science. 2000 May 12;288(5468):1053-8. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N .

Related Pictures

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★リンクテーブル★

リンク元	「病毒」「noxae」「病原性毒素」
拡張検索	「ipenoxazone hydrochloride」「chlorphenoxamine」

「病毒」

　　[★]

英

noxa、noxae

関

病原性毒素

「noxae」

　　[★]

病原性毒素、病毒

関

noxa

「病原性毒素」

　　[★]

英

noxa、noxae

関

病毒

「ipenoxazone hydrochloride」

　　[★]

• 塩酸イペノキサゾン

関

ipenoxazone

「chlorphenoxamine」

　　[★]

クロルフェノキサミン