chlorphenoxamine

Chlorphenoxamine
Systematic (IUPAC) name
	{2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl}dimethylamine
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Routes	Oral, topical
Pharmacokinetic data
Bioavailability	Well absorbed
Metabolism	Likely hepatic
Excretion	Renal
Identifiers
CAS number	77-38-3 562-09-4
ATC code	D04AA34 R06AA06
PubChem	CID 6475
ChemSpider	6230
UNII	3UVD77BP8R
KEGG	D07198
Chemical data
Formula	C18H22ClNO
Mol. mass	303.826 g/mol
	SMILES Clc1ccc(cc1)C(OCCN(C)C)(c2ccccc2)C;
	InChI InChI=1S/C18H22ClNO/c1-18(21-14-13-20(2)3,15-7-5-4-6-8-15)16-9-11-17(19)12-10-16/h4-12H,13-14H2,1-3H3 ; Key:KKHPNPMTPORSQE-UHFFFAOYSA-N ;
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Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/14 04:46:59」(JST)

Chlorphenoxamine (Phenoxene) is an antihistamine and anticholinergic used as an antipruritic^[1] and antiparkinsonian^[2] agent.

^ Bazex, A.; Dupre, A.; Christol, B. (1963). "Trial treatment of urticaria with chlorphenoxamine". Clinique (Paris, France) 58: 447–450. PMID 13967113. edit
^ Uldall, P. R.; Walton, J. N.; Newell, D. J. (1961). "Chlorphenoxamine hydrochloride in parkinsonism. A controlled trial". British medical journal 1 (5240): 1649–1652. doi:10.1136/bmj.1.5240.1649. PMC 1954253. PMID 13779077. edit

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In vitro antibacterial activity of some systemic and topical antihistaminic preparations.

Gocmen JS, Buyukkocak U, Caglayan O.SourceDepartment of Microbiology and Clinical Microbiology, Kirikkale University, 71100 Kirikkale, Turkey. jsedef@yahoo.com
Clinical and investigative medicine. Médecine clinique et experimentale.Clin Invest Med.2009 Dec 1;32(6):E232.
PURPOSE: In vitro antibacterial activity of topical and systemic antihistaminic preparations containing different active substrates against the standard strains of two bacteria was evaluated.METHODS: Four topical and 3 systemic preparations containing pheniramine maleate, chlorophenoxamine hydrochlo
PMID 20003827

Spectrophotometric determination of some histamine H1-antagonists drugs in their pharmaceutical preparations.

Hassan WS, El-Henawee MM, Gouda AA.SourceAnalytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2008 Jan;69(1):245-55. Epub 2007 Mar 31.
Two rapid, simple and sensitive extractive specrophotometric methods has been developed for the determination of three histamine H1-antagonists drugs, e.g., chlorphenoxamine hydrochloride (CPX), diphenhydramine hydrochloride (DPH) and clemastine (CMT) in bulk and in their pharmaceutical formulations
PMID 17553739

Simultaneous determination of caffeine, 8-chlorotheophylline, and chlorphenoxamine hydrochloride in ternary mixtures by ratio-spectra zero-crossing first-derivative spectrophotometric and chemometric methods.

Kelani KM.SourceCairo University, Faculty of Pharmacy, Department of Analytical Chemistry, Kasr El-Aini St, PO Box 11562, Cairo, Egypt.
Journal of AOAC International.J AOAC Int.2005 Jul-Aug;88(4):1126-34.
A ratio-spectra zero-crossing first-derivative spectrophotometric method and 2 chemometric methods have been used for the simultaneous determination of ternary mixtures of caffeine (A), 8-chlorotheophylline (B), and chlorphenoxamine hydrochloride (C) in bulk powder and dosage forms. In the ratio-spe
PMID 16152931