Studies of human brain malformations, such as lissencephaly and double cortex, have revealed the importance of neuronal migration during cortical development. Afadin, a membrane scaffolding protein, regulates the formation of adherens junctions (AJs) and cell migration to form and maintain tissue st
Intrinsic neurophysiological properties of hilar ectopic and normotopic dentate granule cells in human temporal lobe epilepsy and a rat model.
Althaus AL1, Sagher O2, Parent JM1, Murphy GG3.
Journal of neurophysiology.J Neurophysiol.2015 Feb 15;113(4):1184-94. doi: 10.1152/jn.00835.2014. Epub 2014 Nov 26.
Hilar ectopic dentate granule cells (DGCs) are a salient feature of aberrant plasticity in human temporal lobe epilepsy (TLE) and most rodent models of the disease. Recent evidence from rodent TLE models suggests that hilar ectopic DGCs contribute to hyperexcitability within the epileptic hippocampa
Normotopic cortex is the major contributor to epilepsy in experimental double cortex.
Petit LF1, Jalabert M, Buhler E, Malvache A, Peret A, Chauvin Y, Watrin F, Represa A, Manent JB.
Annals of neurology.Ann Neurol.2014 Sep;76(3):428-42. doi: 10.1002/ana.24237. Epub 2014 Aug 11.
OBJECTIVE: Subcortical band heterotopia (SBH) is a cortical malformation formed when neocortical neurons prematurely stop their migration in the white matter, forming a heterotopic band below the normotopic cortex, and is generally associated with intractable epilepsy. Although it is clear that the
… Urological examination such as excretory urogram and abdominal aortography revealed a typical fused pelvic kidney with blood supply of one artery from the bifurcation of the aorta, Cystoscopic examination revealed a normotopic ureterocele on the left side. …
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