- 非線維性の
WordNet
- used to express refusal or denial or disagreement etc or especially to emphasize a negative statement; "no, you are wrong"
- a negative; "his no was loud and clear"
- referring to the degree to which a certain quality is present; "he was no heavier than a child" (同)no more
- not in any degree or manner; not at all; "he is no better today"
- quantifier; used with either mass nouns or plural count nouns for indicating a complete or almost complete lack or zero quantity of; "we have no bananas"; "no eggs left and no money to buy any"; "have you no decency?"; "did it with no help"; "Ill get you there in no time"
- the fifth of the seven canonical hours; about 3 p.m.
PrepTutorEJDIC
- 《名詞の前に置いて》『一つも』(『一人も,少しも』)・・・『ない』 / 《補語につけて》『決して・・・でない』 / 《省略文で》・・・なし;・・・お断り / 《話》少ししか(あまり)・・・ない / (肯定の問いに対して)『いいえ』;(否定の問いに対して)はい,ええ / 《not, norの前に挿入して》『いや』,否 / 《形容詞の前に置その形容詞を否定して》…どころではない / 《比較級の前に置いて》ちっとも…でない,…と全く同じ / 《… or no の形で》…であってもなくても / 《驚き・困惑・不信などを表して》とんでもない / 《単数形で》『拒否』,「『いいえ』」という返事 / 《複数形で》反対[投]票
UpToDate Contents
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- 1. 進行非小細胞肺癌：治療歴がある患者に対する二次療法 advanced non small cell lung cancer subsequent therapies for previously treated patients
- 2. 不安定狭心症および非ST上昇型心筋梗塞の急性期マネージメントの概要 overview of the acute management of unstable angina and non st elevation myocardial infarction
- 3. 非ST上昇型急性冠症候群における抗血小板薬 antiplatelet agents in acute non st elevation acute coronary syndromes
- 4. 脳転移に対する全身療法 systemic therapy for brain metastases
- 5. 多発性骨髄腫の臨床的特徴、検査所見、および診断 clinical features laboratory manifestations and diagnosis of multiple myeloma
English Journal
- Effect of Mechanical Strain on the Collagen VI Pericellular Matrix in Anterior Cruciate Ligament Fibroblasts.
- Sardone F1, Traina F, Tagliavini F, Pellegrini C, Merlini L, Squarzoni S, Santi S, Neri S, Faldini C, Maraldi N, Sabatelli P.Author information 1National Research Council of Italy, Institute of Molecular Genetics, Bologna, Italy; IOR-IRCCS, SC Laboratory of Musculoskeletal Cell Biology, Bologna, Italy.AbstractCell-extracellular matrix interaction plays a major role in maintaining the structural integrity of connective tissues and sensing changes in the biomechanical environment of cells. Collagen VI is a widely expressed non-fibrillar collagen, which regulates tissues homeostasis. The objective of the present investigation was to extend our understanding of the role of collagen VI in human ACL. This study shows that collagen VI is associated both in vivo and in vitro to the cell membrane of knee ACL fibroblasts, contributing to the constitution of a microfibrillar pericellular matrix. In cultured cells the localization of collagen VI at the cell surface correlated with the expression of NG2 proteoglycan, a major collagen VI receptor. The treatment of ACL fibroblasts with anti-NG2 antibody abolished the localization of collagen VI indicating that collagen VI pericellular matrix organization in ACL fibroblasts is mainly mediated by NG2 proteoglycan. In vitro mechanical strain injury dramatically reduced the NG2 proteoglycan protein level, impaired the association of collagen VI to the cell surface, and promoted cell cycle withdrawal. Our data suggest that the injury-induced alteration of specific cell-ECM interactions may lead to a defective fibroblast self-renewal and contribute to the poor regenerative ability of ACL fibroblasts. J. Cell. Physiol. 229: 878-886, 2014. © 2013 Wiley Periodicals, Inc.
- Journal of cellular physiology.J Cell Physiol.2014 Jul;229(7):878-86. doi: 10.1002/jcp.24518.
- Cell-extracellular matrix interaction plays a major role in maintaining the structural integrity of connective tissues and sensing changes in the biomechanical environment of cells. Collagen VI is a widely expressed non-fibrillar collagen, which regulates tissues homeostasis. The objective of the pr
- PMID 24356950
- GPI-anchoring Directs the Assembly of Sup35NM into Non-fibrillar Membrane-bound Aggregates.
- Marshall KE1, Offerdahl DK, Speare JO, Dorward DW, Hasenkrug A, Carmody AB, Baron GS.Author information 1Rocky Mountain Laboratories, NIAID, NIH, United States.AbstractIn prion-infected hosts, PrPSc usually accumulates as non-fibrillar, membrane-bound aggregates. Glycosylphosphatidylinositol (GPI) anchor-directed membrane association appears to be an important factor controlling the biophysical properties of PrPSc aggregates. To determine whether GPI-anchoring can similarly modulate the assembly of other amyloid-forming proteins, neuronal cell lines were generated that expressed a GPI-anchored form of a model amyloidogenic protein, the NM domain of the yeast prion protein Sup35 (Sup35GPI). We recently reported that GPI-anchoring facilitated the induction of Sup35GPI prions in this system. Here, we report the ultrastructural characterization of self-propagating Sup35GPI aggregates of either spontaneous or induced origin. Like membrane-bound PrPSc, Sup35GPI aggregates resisted release from cells treated with phosphatidylinositol-specific phospholipase C. Sup35GPI aggregates of spontaneous origin were detergent-insoluble, protease resistant, and self-propagating, in a manner similar to that reported for recombinant Sup35NM amyloid fibrils and induced Sup35GPI aggregates. However, GPI-anchored Sup35 aggregates were not stained with amyloid-binding dyes such as Thioflavin T. This was consistent with ultrastructural analyses, which showed that the aggregates corresponded to dense cell surface accumulations of membrane vesicle-like structures and were not fibrillar. Together these results showed that GPI-anchoring directs the assembly of Sup35NM into non-fibrillar, membrane-bound aggregates that resemble PrPSc, raising the possibility that GPI anchor-dependent modulation of protein aggregation might occur with other amyloidogenic proteins. This may contribute to differences in pathogenesis and pathology between prion diseases, which uniquely involve aggregation of a GPI-anchored protein, versus other protein misfolding diseases.
- The Journal of biological chemistry.J Biol Chem.2014 Mar 13. [Epub ahead of print]
- In prion-infected hosts, PrPSc usually accumulates as non-fibrillar, membrane-bound aggregates. Glycosylphosphatidylinositol (GPI) anchor-directed membrane association appears to be an important factor controlling the biophysical properties of PrPSc aggregates. To determine whether GPI-anchoring can
- PMID 24627481
- Secrets of the cutaneous basement membrane.
- Karpati S.Author information Department of Dermatology, Venereology and Dermato-oncology, Semmelweis University, Budapest, Hungary.AbstractThe paper in this issue by Has and co-workers reports 15 non-Herlitz epidermolysis bullosa patients with the same single amino-acid substitution in collagen XVII, all of whom presented with clinical and pathological features resembling Kindler syndrome. Here we consider why and how a hemidesmosomal pathology can mimic a focal adhesion bond disease, both clinically and ultrastructurally.
- The Journal of investigative dermatology.J Invest Dermatol.2014 Mar;134(3):602-4. doi: 10.1038/jid.2013.452.
- The paper in this issue by Has and co-workers reports 15 non-Herlitz epidermolysis bullosa patients with the same single amino-acid substitution in collagen XVII, all of whom presented with clinical and pathological features resembling Kindler syndrome. Here we consider why and how a hemidesmosomal
- PMID 24518114
Japanese Journal
- Gamma-cross-linked nonfibrillar collagen gel as a scaffold for osteogenic differentiation of mesenchymal stem cells(CELL AND TISSUE ENGINEERING)
- Takitoh Takako,Bessho Masahiko,Hirose Motohiro,Ohgushi Hajime,Mori Hideki,Hara Masayuki
- Journal of bioscience and bioengineering 119(2), 217-225, 2015-02
- … We fabricated a transparent nonfibrillar collagen gel using gamma irradiation (5 kGy) and cultured rat mesenchymal stem cells (MSCs) on both the gamma-irradiated collagen gel and on unirradiated fibrillar collagen gel. … The cells cultured on the gamma-irradiated non-fibrillar gel had a unique elongated shape and adhered to each other in culture. …
- NAID 110009922498
- Non-fibrillar oligomeric species of the amyloid ABri peptide, implicated in familial British dementia, are more potent at inducing apoptotic cell death than protofibrils or mature fibrils
- EL-AGNAF OM
- J Mol Biol 310, 157-168, 2001
- NAID 30018462692
- Non-fibrillar β-amyloid protein is associated with smooth muscle cells of vessel walls in Alzheimer's disease.
- FRACKOWIACK J.
- J. Neuropath. Exp. Neurol. 53, 637-645, 1994
- NAID 30037200555
Related Links
- Non-Fibrillar Collagens - definition. ... A family of structurally-related short-chain collagens that do not form large fibril bundles. precusors: coord IM with PROCOLLAGEN (IM), Other names Short-Chain Collagens; Short Chain Collagens; Non ...
Related Pictures
★リンクテーブル★
| リンク元 | 「nonfibrillar」「非線維性」 |
| 拡張検索 | 「non-fibrillar collagen」 |
| 関連記事 | 「n」「fibrillar」「non」 |
「nonfibrillar」
- 非線維性の
「非線維性」
「non-fibrillar collagen」
「n」
- n.
- pの前の[n]はmと記載する。synptom→symptom
「fibrillar」
- 原繊維の、原線維の
「non」
- comb form.
- 関
- un