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1. 過敏性腸症候群に対するアロセトロン塩酸塩（Lotronex） alosetron hydrochloride lotronex for irritable bowel syndrome
2. 変形性関節症の初回薬物療法 initial pharmacologic therapy of osteoarthritis
3. クリンダマイシン：概要 clindamycin an overview
4. 成人における急性咽頭炎の対症療法 symptomatic treatment of acute pharyngitis in adults
5. 慢性非アレルギー性鼻炎 chronic nonallergic rhinitis

A phase-1 pharmacokinetic optimal dosing study of intraventricular topotecan for children with neoplastic meningitis: A pediatric brain tumor consortium study.

Blaney SM, Tagen M, Onar-Thomas A, Berg SL, Gururangan S, Scorsone K, Su J, Goldman S, Kieran MW, Kun L, Boyett J, Stewart C.SourceTexas Children's Cancer Center/Baylor College of Medicine, Houston, Texas. sblaney@txch.org.
Pediatric blood & cancer.Pediatr Blood Cancer.2013 Apr;60(4):627-32. doi: 10.1002/pbc.24309. Epub 2012 Sep 21.
PURPOSE: We performed a phase-1 pharmacokinetic optimal dosing study of intraventricular topotecan (IT), administered daily 5×, to determine whether, the maximum tolerated dose of IT topotecan was also the pharmacokinetic optimal dose.PATIENTS AND METHODS: Patients received topotecan administered t
PMID 23002039

Absolute bioavailability studies of a new oral topotecan formulation in Chinese patients using UHPLC-MS/MS.

Li N, Han X, Yang J, Gui L, Song Y, Du P, Shi Y.SourceBeijing Key Laboratory of Clinical Study on Antitumor Molecular Target Drugs, Department of Medical Oncology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2013 Mar 25;76:252-6. doi: 10.1016/j.jpba.2012.12.033. Epub 2013 Jan 4.
Xinze(®) is a new capsule formulation of topotecan being made in China which is similar to Hycamtin(®), the currently available oral formulation approved in 2007 for the treatment of relapsed small cell lung cancer (SCLC). As topotecan bioavailability and pharmacokinetic data for Chinese patients
PMID 23354352

Ocular and systemic toxicity of intravitreal topotecan in rabbits for potential treatment of retinoblastoma.

Buitrago E, Del Sole MJ, Torbidoni A, Fandino A, Asprea M, Croxatto JO, Chantada GL, Bramuglia GF, Schaiquevich P.SourceDepartment of Pharmacology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
Experimental eye research.Exp Eye Res.2013 Mar;108:103-9. doi: 10.1016/j.exer.2013.01.002. Epub 2013 Jan 16.
Treatment of intraocular retinoblastoma with vitreous seeding is a challenge. Different routes of chemotherapy administration have been explored in order to attaining pharmacological concentrations into the posterior chamber. Intravitreal drug injection is a promissing route for maximum bioavailabil
PMID 23333535