ニコチンアミドヌクレオチドアデニル基転移酵素、ニコチンアミドヌクレオチドアデニリルトランスフェラーゼ
WordNet
- a phosphoric ester of a nucleoside; the basic structural unit of nucleic acids (DNA or RNA) (同)base
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/31 03:36:51」(JST)
[Wiki en表示]
| nicotinamide-nucleotide adenylyltransferase |
| Identifiers |
| EC number |
2.7.7.1 |
| CAS number |
9032-70-6 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
In enzymology, a nicotinamide-nucleotide adenylyltransferase (EC 2.7.7.1) is an enzyme that catalyzes the chemical reaction
- ATP + nicotinamide ribonucleotide diphosphate + NAD+
Thus, the two substrates of this enzyme are ATP and nicotinamide ribonucleotide, whereas its two products are diphosphate and NAD+.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:nicotinamide-nucleotide adenylyltransferase. Other names in common use include NAD+ pyrophosphorylase, adenosine triphosphate-nicotinamide mononucleotide transadenylase, ATP:NMN adenylyltransferase, diphosphopyridine nucleotide pyrophosphorylase, nicotinamide adenine dinucleotide pyrophosphorylase, nicotinamide mononucleotide adenylyltransferase, and NMN adenylyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism. The human version of this protein is NMNAT1.
Structural studies
As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes 1EJ2, 1GZU, 1HYB, 1KKU, 1KQN, 1KQO, 1KR2, 1M8F, 1M8G, 1M8J, and 1M8K.
References
- ATKINSON MR, JACKSON JF, MORTON RK (1961). "Nicotinamide mononucleotide adenylyltransferase of pig-liver nuclei. The effects of nicotinamide mononucleotide concentration and pH on dinucleotide synthesis". Biochem. J. 80 (2): 318–23. PMC 1244001. PMID 13684981.
- Dahmen W, Webb B, Preiss J (1967). "The deamido-diphosphopyridine nucleotide and diphosphopyridine nucleotide pyrophosphorylases of Escherichia coli and yeast". Arch. Biochem. Biophys. 120 (2): 440–50. doi:10.1016/0003-9861(67)90262-7. PMID 4291828.
- Kornberg A and Pricer WE (1951). "Enzymatic cleavage of diphosphopyridine nucleotide with radioactive pyrophosphate". J. Biol. Chem. 191 (2): 535–541. PMID 14861199.
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Transferases: phosphorus-containing groups (EC 2.7)
|
|
2.7.1-2.7.4:
phosphotransferase/kinase
(PO4) |
| 2.7.1: OH acceptor |
- Hexo-
- Gluco-
- Fructo-
- Galacto-
- Phosphofructo-
- 1
- Liver
- Muscle
- Platelet
- 2
- Riboflavin
- Shikimate
- Thymidine
- NAD+
- Glycerol
- Pantothenate
- Mevalonate
- Pyruvate
- Deoxycytidine
- PFP
- Diacylglycerol
- Phosphoinositide 3
- Class I PI 3
- Class II PI 3
- Sphingosine
- Glucose-1,6-bisphosphate synthase
|
|
| 2.7.2: COOH acceptor |
- Phosphoglycerate
- Aspartate kinase
|
|
| 2.7.3: N acceptor |
|
|
| 2.7.4: PO4 acceptor |
- Phosphomevalonate
- Adenylate
- Nucleoside-diphosphate
- Uridylate
- Guanylate
- Thiamine-diphosphate
|
|
|
2.7.6: diphosphotransferase
(P2O7) |
- Ribose-phosphate diphosphokinase
- Thiamine diphosphokinase
|
|
2.7.7: nucleotidyltransferase
(PO4-nucleoside) |
| Polymerase |
| DNA polymerase |
- DNA-directed DNA polymerase
- I
- II
- III
- IV
- V
- RNA-directed DNA polymerase
- Reverse transcriptase
- Telomerase
- DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase
|
|
| RNA nucleotidyltransferase |
- RNA polymerase/DNA-directed RNA polymerase
- RNA polymerase I
- RNA polymerase II
- RNA polymerase III
- RNA polymerase IV
- Primase
- RNA-dependent RNA polymerase
- PNPase
|
|
|
Phosphorolytic
3' to 5' exoribonuclease |
|
|
| Nucleotidyltransferase |
- UTP—glucose-1-phosphate uridylyltransferase
- Galactose-1-phosphate uridylyltransferase
|
|
| Guanylyltransferase |
|
|
| Other |
- Recombinase (Integrase)
- Transposase
|
|
|
| 2.7.8: miscellaneous |
| Phosphatidyltransferases |
- CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
- CDP-diacylglycerol—serine O-phosphatidyltransferase
- CDP-diacylglycerol—inositol 3-phosphatidyltransferase
- CDP-diacylglycerol—choline O-phosphatidyltransferase
|
|
| Glycosyl-1-phosphotransferase |
- N-acetylglucosamine-1-phosphate transferase
|
|
|
2.7.10-2.7.13: protein kinase
(PO4; protein acceptor) |
| 2.7.10: protein-tyrosine |
|
|
| 2.7.11: protein-serine/threonine |
- see serine/threonine-specific protein kinases
|
|
| 2.7.12: protein-dual-specificity |
- see serine/threonine-specific protein kinases
|
|
| 2.7.13: protein-histidine |
- Protein-histidine pros-kinase
- Protein-histidine tele-kinase
- Histidine kinase
|
|
|
|
Enzymes
|
|
| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
|
| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
|
| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
|
|
| Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
|
|
UpToDate Contents
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- 1. 色素性乾皮症xeroderma pigmentosum [show details]
… that nicotinamide has a chemoprotective effect . In a large, multicenter, randomized trial including 386 immunocompetent participants with a history of NMSC, patients taking nicotinamide developed… pyrimidone photoproducts [6-4PPs]) in a pathway called nucleotide excision repair (NER) .…
- 2. 皮膚扁平上皮癌の疫学および危険因子epidemiology and risk factors for cutaneous squamous cell carcinoma [show details]
… mg of nicotinamide twice daily or placebo for 12 months. The primary endpoint was the number of new nonmelanoma skin cancers at 12 months. At the end of the study, patients in the nicotinamide group… Germline single nucleotide polymorphisms (SNP) in cSCCs have been identified in…
- 3. 水疱性類天疱瘡のマネージメントおよび予後management and prognosis of bullous pemphigoid [show details]
…prednisone and tetracycline plus nicotinamide in patients with BP. In the randomized trial (n = 20), eight weeks of tetracycline (500 mg four times per day) plus nicotinamide (500 mg three times per day) was …
- 4. 基底細胞癌の疫学、発症機序、臨床的特徴epidemiology pathogenesis and clinical features of basal cell carcinoma [show details]
… with 500 mg of nicotinamide twice daily or placebo for 12 months. The primary endpoint was the number of new NMSCs at 12 months. At the end of the study, patients in the nicotinamide group had… A genome-wide association meta-analysis found that single nucleotide polymorphisms in genes involved in DNA excision repair…
- 5. 筋肉におけるエネルギー代謝energy metabolism in muscle [show details]
… which phosphocreatine is converted to ATP; Purine nucleotide cycle; Lipid metabolism; Energy generation via… The reduced forms of nicotinamide adenine dinucleotide (NADH) and flavin adenine…
English Journal
- Axon degeneration: where the Wlds things are.
- Wang JT, Barres BA.SourceDepartment of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA. jtw@stanford.edu
- Current biology : CB.Curr Biol.2012 Apr 10;22(7):R221-3.
- Expression of the Wld(s) protein significantly delays axon degeneration in injuries and diseases, but the mechanism for this protection is unknown. Two recent reports present evidence that axonal mitochondria are required for Wld(S)-mediated axon protection.Copyright © 2012 Elsevier Ltd. All righ
- PMID 22497934
- WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering.
- Avery MA, Rooney TM, Pandya JD, Wishart TM, Gillingwater TH, Geddes JW, Sullivan PG, Freeman MR.SourceDepartment of Neurobiology, University of Massachusetts Medical School, and Howard Hughes Medical Institute, Worcester, MA 01605-2324, USA.
- Current biology : CB.Curr Biol.2012 Apr 10;22(7):596-600. Epub 2012 Mar 15.
- Wld(S) (slow Wallerian degeneration) is a remarkable protein that can suppress Wallerian degeneration of axons and synapses, but how it exerts this effect remains unclear. Here, using Drosophila and mouse models, we identify mitochondria as a key site of action for Wld(S) neuroprotective function. T
- PMID 22425157
Related Links
- The official name of this gene is “nicotinamide nucleotide adenylyltransferase 1.” NMNAT1 is the gene's official symbol. The NMNAT1 gene is also known by other names, listed below. Read more about gene names and ...
- 608700 - NICOTINAMIDE NUCLEOTIDE ADENYLYLTRANSFERASE 1; NMNAT1 - NMNAT;; PYRIDINE NUCLEOTIDE ADENYLYLTRANSFERASE 1; PNAT1 - NMNAT1 Home About Statistics Downloads Help * ...
★リンクテーブル★
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- 英
- nicotinamide-nucleotide adenylyltransferase
- 関
- ニコチンアミドヌクレオチドアデニリルトランスフェラーゼ
[★]
- 英
- nicotinamide-nucleotide adenylyltransferase
- 関
- ニコチンアミドヌクレオチドアデニル基転移酵素
[★]
アデニリルトランスフェラーゼ、アデニル酸転移酵素
[★]
ニコチンアミド、ニコチン酸アミド