WordNet

(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
autosomal dominant disease characterized by numerous neurofibromas and by spots on the skin and often by developmental abnormalities (同)von Recklinghausen''s disease
informal term for information; "give me the gen on your new line of computers"

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1. 神経線維腫症I型（NF1）：病因、臨床的特徴、および診断 neurofibromatosis type 1 nf1 pathogenesis clinical features and diagnosis
2. 急性骨髄性白血病の分子遺伝学 molecular genetics of acute myeloid leukemia
3. 軟部および骨肉腫の病原因子 pathogenetic factors in soft tissue and bone sarcomas
4. 神経線維腫症I型（NF1）：マネージメントおよび予後 neurofibromatosis type 1 nf1 management and prognosis
5. 神経線維腫症2型 neurofibromatosis type 2

Wiesner T1, Kiuru M, Scott SN, Arcila M, Halpern AC, Hollmann T, Berger MF, Busam KJ.
The American journal of surgical pathology.Am J Surg Pathol.2015 Oct;39(10):1357-62. doi: 10.1097/PAS.0000000000000451.
Desmoplastic melanoma (DM) is a rare variant of melanoma with distinct clinical, histopathologic, and immunohistochemical features. Clinically, DM differs from conventional melanoma by a higher propensity for local recurrence and less frequent metastatic spread to regional lymph nodes. In its pure f
PMID 26076063

Riccardi VM1.
American journal of medical genetics. Part A.Am J Med Genet A.2015 Jul;167(7):1570-7. doi: 10.1002/ajmg.a.37045. Epub 2015 May 14.
A patient with NF1 was treated with oral ketotifen for 30 years since infancy. Review of the patient's course and treatment details establishes a basis for reconsideration of several fundamental precepts about NF1 pathogenesis. The data suggest a distinctive benefit to treating an NF1 patient with a
PMID 25974154

Molecular Characterization of NF1 and Neurofibromatosis Type 1 Genotype-Phenotype Correlations in a Chinese Population.

Zhang J1, Tong H2, Fu X3, Zhang Y2, Liu J4, Cheng R1, Liang J1, Peng J5, Sun Z6, Liu H3, Zhang F3, Lu W2, Li M1, Yao Z1.
Scientific reports.Sci Rep.2015 Jun 9;5:11291. doi: 10.1038/srep11291.
Neurofibromatosis type 1 (NF1) is an autosomal dominant hereditary disease that is primarily characterized by multiple café au-lait spots (CALs) and skin neurofibromas, which are attributed to defects in the tumor suppressor NF1. Because of the age-dependent presentation of NF1, it is often difficu
PMID 26056819

尾上義浩,小池修治,那須隆,野田大介,石田晃弘,石井健一,青柳優
耳鼻咽喉科臨床 102(11), 931-937, 2009-11-01
… We report a case of leiomyosarcoma of the nasal cavity with neurofibromatosis type 1 (NF1). … The risk of malignancy among NF1 patients is higher than among the general population, i.e., the NF1 gene is a tumor suppressor gene of which mutation involves a fourfold increased risk for cancer. … The NF1 gene product neurofibromin is thought to deliver much of its function by downregulating the oncogene ras. …
NAID 10025527376

GASTRIC SCHWANNOMA WITH ADJACENT EXTERNAL PROGRESSION HARBORED ABERRANT NF2 GENE

OGASAWARA NAOTAKA,SASAKI MAKOTO,ISHIGURO HIDEYUKI,ITOH YUKIMI,NOJIRI SYUNSUKE,KUBOTA EIJI,WADA TSUNEYA,KATAOKA HIROMI,KUWABARA YOSHIYUKI,JOH TAKASHI
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 21(3), 192-195, 2009-07-01
NAID 10026611357