WordNet

(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
informal term for information; "give me the gen on your new line of computers"

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Macrophage repolarization with targeted alginate nanoparticles containing IL-10 plasmid DNA for the treatment of experimental arthritis.

Jain S1, Tran TH1, Amiji M2.
Biomaterials.Biomaterials.2015 Aug;61:162-77. doi: 10.1016/j.biomaterials.2015.05.028. Epub 2015 May 19.
In this study, we have shown for the first time the effectiveness of a non-viral gene transfection strategy to re-polarize macrophages from M1 to M2 functional sub-type for the treatment of rheumatoid arthritis (RA). An anti-inflammatory (IL-10) cytokine encoding plasmid DNA was successfully encapsu
PMID 26004232

Understanding of altered N-glycosylation-related gene expression in recombinant Chinese hamster ovary cells subjected to elevated ammonium concentration by digital mRNA counting.

Ha TK1, Kim YG2, Lee GM3.
Biotechnology and bioengineering.Biotechnol Bioeng.2015 Aug;112(8):1583-93. doi: 10.1002/bit.25568. Epub 2015 Mar 10.
To understand the effects of ammonium on N-glycosylation, recombinant Chinese hamster ovary (rCHO) cells that produce the Fc-fusion protein were cultivated in serum-free suspension cultures with 10 mM ammonium addition. The addition of ammonium to the cultures reduced the relative proportion of ac
PMID 25728222

A multicenter study shows PTEN deletion is strongly associated with seminal vesicle involvement and extracapsular extension in localized prostate cancer.

Troyer DA1,2, Jamaspishvili T3, Wei W4, Feng Z4, Good J3, Hawley S5, Fazli L6, McKenney JK7, Simko J8,9, Hurtado-Coll A6, Carroll PR9, Gleave M6, Lance R10, Lin DW11, Nelson PS12, Thompson IM13, True LD14, Brooks JD15, Squire JA3,16.
The Prostate.Prostate.2015 Aug;75(11):1206-15. doi: 10.1002/pros.23003. Epub 2015 May 4.
BACKGROUND: Loss of the phosphatase and tensin homolog (PTEN) tumor suppressor gene is a promising marker of aggressive prostate cancer. Active surveillance and watchful waiting are increasingly recommended to patients with small tumors felt to be low risk, highlighting the difficulties of Gleason s
PMID 25939393

Co-expression of a heat shock transcription factor to improve conformational quality of recombinant protein in Escherichia coli(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)

Hsu Shao-Yen,Lin Yu-Sheng,Li Shu-Jyuan,Lee Wen-Chien
Journal of bioscience and bioengineering 118(3), 242-248, 2014-09
… A Shine-Dalgarno sequence and the rpoH gene of E. … coli, which encodes σ^<32>, were cloned into a bacterial plasmid containing a gene fusion encoding a doubly tagged N-acetyl-D-neuraminic acid aldolase (GST-Neu5Ac aldolase-5R). … Nevertheless, the co-expression of sigma 32 led to higher level of Neu5Ac aldolase enzymatic activity in both the soluble and insoluble (inclusion body) fractions. …
NAID 110009857351

Comparative gene expression analysis of the amygdala in autistic rat models produced by pre- and post-natal exposures to valproic acid

Oguchi-Katayama Atsuko,Monma Akihiko,Sekino Yuko,Moriguchi Toru,Sato Kaoru
The Journal of Toxicological Sciences 38(3), 391-402, 2013
… Gene expression profiles in the amygdala of juvenile rats were compared between the two autistic rat models for mechanistic insights into impaired social behavior and enhanced anxiety in autism. … Gene expression profiles in the amygdala of the rats (E12IP and P14SC) were analyzed by microarray and compared to each other. …
NAID 130004447056

Clinical and Serial MRI Findings of a Sialidosis Type I Patient with a Novel Missense Mutation in the NEU1 Gene

Sekijima Yoshiki,Nakamura Katsuya,Kishida Dai,Narita Aya,Adachi Kaori,Ohno Kosaku,Nanba Eiji,Ikeda Shu-ichi
Internal Medicine 52(1), 119-124, 2013
… The case of a Japanese sialidosis type I patient with a novel NEU1 gene mutation is described. … An NEU1 gene analysis identified two heterozygous missense mutations: p.P80L and p.D135N. …
NAID 130003365573