WordNet

(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
informal term for information; "give me the gen on your new line of computers"

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1. 乳癌におけるHER2と治療の効果予測 her2 and predicting response to therapy in breast cancer
2. HER2陽性転移性乳癌の全身治療 systemic treatment for her2 positive metastatic breast cancer
3. HER2陽性乳癌患者への術前補助療法 neoadjuvant therapy for patients with her2 positive breast cancer
4. HER2陽性乳癌への術後補助全身療法 adjuvant systemic therapy for her2 positive breast cancer
5. トラスツズマブおよびその他の抗HER2薬の心毒性 cardiotoxicity of trastuzumab and other her2 targeted agents

In Vivo Assessment of HER2 Receptor Density in HER2-positive Tumors by Near-infrared Imaging, Using Repeated Injections of the Fluorescent Probe.

Ardeshirpour Y1, Hassan M, Zielinski R, Horton JA, Capala J, Gandjbakhche AH, Chernomordik V.
Technology in cancer research & treatment.Technol Cancer Res Treat.2014 Oct;13(5):427-34. doi: 10.7785/tcrtexpress.2013.600265. Epub 2013 Aug 31.
HER2 overexpression and amplification of the HER2/neu gene have been found in approximately 25% of invasive breast carcinomas. They are associated with a poor prognosis and resistance to therapy in breast cancer patients. Up to now, clinical evaluation of human epidermal growth factor receptor 2 (HE
PMID 24000992

Oral epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small cell lung cancer: Comparative pharmacokinetics and drug-drug interactions.

Peters S1, Zimmermann S2, Adjei AA3.
Cancer treatment reviews.Cancer Treat Rev.2014 Sep;40(8):917-926. doi: 10.1016/j.ctrv.2014.06.010. Epub 2014 Jul 1.
The development of orally active small molecule inhibitors of the epidermal growth factor receptor (EGFR) has led to new treatment options for non-small cell lung cancer (NSCLC). Patients with activating mutations of the EGFR gene show sensitivity to, and clinical benefit from, treatment with EGFR t
PMID 25027951

Santillán-Benítez JG1, Mendieta-Zerón H2, Gómez-Oliván LM3, Ordóñez Quiroz A4, Torres-Juárez JJ5, González-Bañales JM6.
Gene.Gene.2014 Aug 15;547(1):70-6. doi: 10.1016/j.gene.2014.06.025. Epub 2014 Jun 13.
INTRODUCTION: Breast cancer is a disease that arises from the accumulation of alterations in the genome of cells that make up the mammary gland. The Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway has been reported to participate in the development
PMID 24932998

p53 accumulation is a strong predictor of recurrence in estrogen receptor-positive breast cancer patients treated with aromatase inhibitors

Yamamoto Mitsugu,Hosoda Mitsuchika,Nakano Kiichiroh,Jia Shusheng,Hatanaka Kanako C.,Takakuwa Emi,Hatanaka Yutaka,Matsuno Yoshihiro,Yamashita Hiroko
Cancer science 105(1), 81-88, 2014-01
… Whole genome analysis identified that a TP53 gene mutation exists in ER-positive breast cancers, although the frequency of TP53 gene mutation in luminal tumors is lower compared with basal-like or human epidermal growth factor receptor type 2 (HER2)-positive breast cancers. …
NAID 120005411143

Mitsudomi Tetsuya
Acta Medica Kinki University 38(1), 7-24, 2013-06
… [Abstract]　Discovery of activating mutation of the EGFR gene in 2004 opened the era of personalized therapy in thoracic oncology. … List of addicted oncogenes is expanding continuously and now it includes HER2, ROS1 or RET in adenocarcinoma of the lung.Efforts are also being made to identify addicted oncogenes in squamous cell carcinoma. … Mechanisms of the resistance include secondary mutations of the targeted gene and activation of alternative pathways. …
NAID 120005324275

大河内美奈
電子情報通信学会技術研究報告. OME, 有機エレクトロニクス 112(333), 19-22, 2012-11-28
… 腹腔洗浄液からの胃がん細胞の検出を想定し、液滴内に胃がん細胞N87株を1%および10%混合し、液滴搬送システムを利用した1細胞レベルでのHER2の遺伝子発現解析について検討したところ、がん細胞の存在割合に従いHER2の発現が高い細胞が検出された。 …
NAID 110009667371