WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons.

Poliak S1, Morales D2, Croteau LP2, Krawchuk D2, Palmesino E2, Morton S1, Jean-François C3, Charron F4, Dalva MB5, Ackerman SL6, Kao TJ7, Kania A8.
eLife.Elife.2015 Dec 3;4. pii: e10841. doi: 10.7554/eLife.10841. [Epub ahead of print]
During neural circuit assembly, axonal growth cones are exposed to multiple guidance signals at trajectory choice points. While axonal responses to individual guidance cues have been extensively studied, less is known about responses to combination of signals and underlying molecular mechanisms. Her
PMID 26633881

Lu YC1, Nazarko OV1, Sando R 3rd2, Salzman GS1, Südhof TC2, Araç D3.
Structure (London, England : 1993).Structure.2015 Sep 1;23(9):1678-91. doi: 10.1016/j.str.2015.06.024. Epub 2015 Jul 30.
Fibronectin leucine-rich repeat transmembrane proteins (FLRTs) are cell-adhesion molecules with emerging functions in cortical development and synapse formation. Their extracellular regions interact with latrophilins (LPHNs) to mediate synapse development, and with Uncoordinated-5 (UNC5)/netrin rece
PMID 26235030

The Intracellular Domain of the Frazzled/DCC Receptor Is a Transcription Factor Required for Commissural Axon Guidance.

Neuhaus-Follini A1, Bashaw GJ2.
Neuron.Neuron.2015 Aug 19;87(4):751-63. doi: 10.1016/j.neuron.2015.08.006.
In commissural neurons of Drosophila, the conserved Frazzled (Fra)/Deleted in Colorectal Cancer (DCC) receptor promotes midline axon crossing by signaling locally in response to Netrin and by inducing transcription of commissureless (comm), an antagonist of Slit-Roundabout midline repulsion, through
PMID 26291159

Increased Expression of Netrin-1 and Its Deleted in Colorectal Cancer Receptor in Human Diseased Lumbar Intervertebral Disc Compared With Autopsy Control