Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/18 14:38:30」(JST)

wiki en

Nalfurafine (INN and USAN;^[1] also known as AC-820, TRK-820; trade name Remitch) is a κ-opioid receptor agonist marketed as a treatment for uremic pruritus in people undergoing hemodialysis.^[2]

As of January 2010^[update], it is also being investigated for the treatment of pruritus in patients with chronic liver disease.^[3]

References

^ Statement on a Nonproprietary Name adopted by the USAN Council
^ "AC-820". Acologix. 2009.
^ Clinical trial number NCT00638495 for "Phase II Study of TRK-820 Soft Capsules — Intractable Pruritus in Patients With Chronic Liver Disease" at ClinicalTrials.gov

This dermatologic drug article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. そう痒症：マネージメントの概要 pruritus overview of management
2. 尿毒症性そう痒症 uremic pruritus

English Journal

Targeting multiple opioid receptors - improved analgesics with reduced side effects?

Günther T1, Dasgupta P1, Mann A1, Miess E1, Kliewer A1, Fritzwanker S1, Steinborn R1, Schulz S1.
British journal of pharmacology.Br J Pharmacol.2017 Apr 5. doi: 10.1111/bph.13809. [Epub ahead of print]
PMID 28378462

Nalfurafine is a G-protein biased agonist having significantly greater bias at the human than rodent form of the kappa opioid receptor.

Schattauer SS1, Kuhar JR1, Song A1, Chavkin C2.
Cellular signalling.Cell Signal.2017 Apr;32:59-65. doi: 10.1016/j.cellsig.2017.01.016. Epub 2017 Jan 11.
PMID 28088389

Predictors of pruritus in patients with chronic liver disease and usefulness of nalfurafine hydrochloride.

Akuta N1, Kumada H1, Fujiyama S1, Kawamura Y1, Sezaki H1, Hosaka T1, Kobayashi M1, Kobayashi M2, Saitoh S1, Suzuki Y1, Suzuki F1, Arase Y1, Ikeda K1.
Hepatology research : the official journal of the Japan Society of Hepatology.Hepatol Res.2017 Mar 21. doi: 10.1111/hepr.12894. [Epub ahead of print]
PMID 28322485

Related Pictures

[Full text] Nalfurafine hydrochloride to treat pruritus: a review | CCID NALFURAFINE MSDS | 152657-84-6 MSDS View And Download - Chemical Cloud Database 2Z-Nalfurafine - Sinco Pharmachem Inc. 研究内容 | 筑波大学国際統合睡眠医科学研究機構長瀬研究室 Uremic pruritus - Kidney International Nalfurafine hydrochloride to treat pruritus: a review | CCID [Full text] Nalfurafine hydrochloride to treat pruritus: a review | CCID Acute Complications of Hemodialysis - ppt video online download

★リンクテーブル★

リンク元

「ナルフラフィン」

Nalfurafine
Systematic (IUPAC) name
	(2E)-N-[(5α,6β)-17-(cyclopropylmethyl)- 3,14-dihydroxy- 4,5-epoxymorphinan- 6-yl]- 3-(3-furyl)- N-methylacrylamide
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	intravenous
Identifiers
CAS Number	152658-17-8
ATC code	V03AX02
PubChem	CID: 6445230
IUPHAR/BPS	1651
ChemSpider	4949003
UNII	XC41AVD567
ChEMBL	CHEMBL267495
Synonyms	TRK-820
Chemical data
Formula	C28H32N2O5
Molecular mass	476.564 g/mol
	SMILES CN([C@@H]1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC6CC6)O)C(=O)/C=C/C7=COC=C7 ;
	InChI InChI=1S/C28H32N2O5/c1-29(23(32)7-4-18-9-13-34-16-18)20-8-10-28(33)22-14-19-5-6-21(31)25-24(19)27(28,26(20)35-25)11-12-30(22)15-17-2-3-17/h4-7,9,13,16-17,20,22,26,31,33H,2-3,8,10-12,14-15H2,1H3/b7-4+/t20-,22-,26+,27+,28-/m1/s1 ; Key:XGZZHZMWIXFATA-UEZBDDGYSA-N ;
(what is this?) (verify)

　　[★]

英: nalfurafine
同: ナルフラフィン塩酸塩、nalfurafine hydrochloride
商: レミッチ
関: その他の中枢神経系用薬

[1] Statement on a Nonproprietary Name adopted by the USAN Council

[2] "AC-820". Acologix. 2009.

[3] Clinical trial number NCT00638495 for "Phase II Study of TRK-820 Soft Capsules — Intractable Pruritus in Patients With Chronic Liver Disease" at ClinicalTrials.gov

匿名

検索

案内

案内

nalfurafine