WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
tending to undergo or resulting from mutation; "a mutant gene"
an animal that has undergone mutation
(biology) an organism that has characteristics resulting from chromosomal alteration (同)mutation, variation, sport

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1. 進行腎細胞癌に対する抗血管新生療法および分子標的療法 anti angiogenic and molecularly targeted therapy for advanced renal cell carcinoma
2. 異型鎌状赤血球症候群 variant sickle cell syndromes
3. 赤血球細胞の力学 red blood cell mechanics
4. びまん性大細胞型B細胞性リンパ腫および原発性縦隔大細胞型B細胞リンパ腫の病理学 pathobiology of diffuse large b cell lymphoma and primary mediastinal large b cell lymphoma
5. 末梢性T細胞リンパ腫の初期治療 initial treatment of peripheral t cell lymphoma

Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma.

Bussey KJ1,2, Bapat A3, Linnehan C4, Wandoloski M5, Dastrup E6, Rogers E7, Gonzales P8, Demeure MJ9.
Clinical and translational medicine.Clin Transl Med.2016 Dec;5(1):1. doi: 10.1186/s40169-015-0080-3. Epub 2016 Jan 11.
BACKGROUND: Adrenocortical carcinoma (ACC) is an aggressive cancer with a 5 year survival rate of 20-30 %. Various factors have been implicated in the pathogenesis of ACC including dysregulation of the G2/M transition and aberrant activity of p53 and MDM2. Polo-like kinase 1 (PLK-1) negatively mod
PMID 26754547

Esposito S1, Tosco A2, Villella VR1, Raia V3, Kroemer G4,5,6,7,8,9,10, Maiuri L11,12.
Molecular and cellular pediatrics.Mol Cell Pediatr.2016 Dec;3(1):13. doi: 10.1186/s40348-016-0040-z. Epub 2016 Mar 14.
Cystic fibrosis (CF) is a lethal monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that entails the (diagnostic) increase in sweat electrolyte concentrations, progressive lung disease with chronic inflammation and recurrent bacterial infecti
PMID 26976279

Detection of paternally inherited fetal point mutations for β-thalassemia in maternal plasma using simple fetal DNA enrichment protocol with or without whole genome amplification: an accuracy assessment.

Ramezanzadeh M1, Salehi M1, Farajzadegan Z2, Kamali S1, Salehi R1.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.J Matern Fetal Neonatal Med.2016 Aug;29(16):2645-9. doi: 10.3109/14767058.2015.1095883. Epub 2015 Nov 9.
OBJECTIVE: To design and evaluate a noninvasive protocol for prenatal diagnosis (PND) of β-thalassemia, using cell free fetal DNA (cff-DNA) in maternal circulation. Traditional current PND which is mainly based on chorionic villous sampling (CVS), amplification refractory mutation system and sequen
PMID 26553322

Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein.

Uemura Norihito,Koike Masato,Ansai Satoshi,Kinoshita Masato,Ishikawa-Fujiwara Tomoko,Matsui Hideaki,Naruse Kiyoshi,Sakamoto Naoaki,Uchiyama Yasuo,Todo Takeshi,Takeda Shunichi,Yamakado Hodaka,Takahashi Ryosuke
PLOS genetics 11(4), 2015-04-02
… To investigate how GBA mutations cause PD, we generated GBA nonsense mutant (GBA-/-) medaka that are completely deficient in glucocerebrosidase (GCase) activity. … GBA-/- medaka displayed the pathological phenotypes resembling human neuronopathic GD including infiltration of Gaucher cell-like cells into the brains, progressive neuronal loss, and microgliosis. …
NAID 120005593596

Suppressing TGFβ signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer

Oshima Hiroko,Nakayama Mizuho,Han Tae-Su,Naoi Kuniko,Ju Xiaoli,Maeda Yusuke,Robine Sylvie,Tsuchiya Kiichiro,Sato Toshiro,Sato Hiroshi,Taketo Makoto Mark,Oshima Masanobu
Cancer Research 75(4), 766-776, 2015-02-15
… We have examined ApcΔ716 TGFβr2ΔIEC compound mutant mice that carry mutations in Apc and TGFβr2 genes in the intestinal epithelial cells. … We further found that regeneration was impaired in TGFβr2ΔIEC mice for intestinal mucosa damaged by DSS treatment or X-ray irradiation, resulting in the expansion of undifferentiated epithelial cell population. …
NAID 120005593962

Functional Differences between GDNF-Dependent and FGF2-Dependent Mouse Spermatogonial Stem Cell Self-Renewal

Takashima Seiji,Kanatsu-Shinohara Mito,Tanaka Takashi,Morimoto Hiroko,Inoue Kimiko,Ogonuki Narumi,Jijiwa Mayumi,Takahashi Masahide,Ogura Atsuo,Shinohara Takashi
Stem Cell
… Earlier studies showed that glial cell line-derived neurotrophic factor (GDNF) was indispensable for SSC self-renewal by binding to the GFRA1/RET receptor. … A small number of spermatogonia formed colonies when testis fragments from a Ret mutant mouse strain were transplanted into heterologous recipients. …
NAID 120005540400