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1. 成人におけるうつ病治療としてのモノアミン酸化酵素阻害剤（MAOI）monoamine oxidase inhibitors maois for treating depressed adults [show details]
…medications has proceeded through several historical phases. The older antidepressants such as monoamine oxidase inhibitors and early tricyclic antidepressants were discovered largely by serendipity. While effective …
2. 尿酸腎結石症uric acid nephrolithiasis [show details]
…and xanthine oxidase inhibitors; Urinary alkalinization and increased fluid intake should be prescribed to almost all patients with uric acid stones. The indications for xanthine oxidase inhibitors to …
3. 慢性肉芽腫性疾患：病因、臨床症状、および診断chronic granulomatous disease pathogenesis clinical manifestations and diagnosis [show details]
…adenine dinucleotide phosphate (NADPH) oxidase The sensitivity and quantitative nature of this assay make it possible to differentiate oxidase-positive from oxidase-negative phagocyte subpopulations in …
4. 新生児における筋緊張低下を引き起こす末梢神経および筋肉の障害に関する概要overview of peripheral nerve and muscle disorders causing hypotonia in the newborn [show details]
…two years. Other presentations of cytochrome c oxidase deficiency have a more prominent encephalopathic component (eg, Leigh syndrome) . Cytochrome c oxidase deficiency is associated with pathologic mutations …
5. リウマチ性疾患に使用した場合のアザチオプリンの薬理作用および副作用pharmacology and side effects of azathioprine when used in rheumatic diseases [show details]
…oxidation to 6-thiouric acid, which is an inactive metabolite. This reaction is catalyzed by xanthine oxidase, which is concentrated in the intestine and liver. It is also metabolized along an anabolic pathway …

English Journal

Sesquiterpenoids and 2-(2-phenylethyl)chromones respectively acting as α-glucosidase and tyrosinase inhibitors from agarwood of an Aquilaria plant.

Yang L, Yang YL, Dong WH, Li W, Wang P, Cao X, Yuan JZ, Chen HQ, Mei WL, Dai HF.
Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1)853-862.
The ethyl ether extract of agarwood from an Aquilaria plant afforded six new sesquiterpenoids, Agarozizanol A - F (1-6), together with four known sesquiterpenoids and six known 2-(2-phenylethyl)chromones. Their structures were elucidated via detailed spectroscopic analysis, X-ray diffraction, an
PMID 31010356

A comprehensive review on tyrosinase inhibitors.

Zolghadri S, Bahrami A, Hassan Khan MT, Munoz-Munoz J, Garcia-Molina F, Garcia-Canovas F, Saboury AA.
Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1)279-309.
Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and plays an important role in the melanogenesis and enzymatic browning. Therefore, its inhibitors can be attractive in cosmetics and medicinal industries as depigmentation agents and also in food and agriculture
PMID 30734608

Chemical composition and enzyme inhibition of Phytolacca dioica L. seeds extracts.

Di Petrillo A, María González-Paramás A, Rosa A, Ruggiero V, Boylan F, Kumar A, Pintus F, Santos-Buelga C, Fais A, Era B.
Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1)519-527.
Phytolacca, which belongs to the family of Phytolaccaceae, are known for their use in popular medicine. Bioactivity of five extracts from Phytolacca dioica seeds were evaluated in four bioassays. A selected group of compounds from the extract that displayed the best bioactivity was analysed. The eth
PMID 30688117

Japanese Journal

化学的・酵素的変換を用いた生理活性ロドデンドロール酸化体の創製

岩舘丈央,二瓶賢一
天然有機化合物討論会講演要旨集 56(0), Poster69, 2014
1. 目的チロシナーゼ(ポリフェノールオキシダーゼ)は，自然界に広く分布する酸化還元酵素である．その活性中心に存在するヒスチジン残基は，様々なフェノール類を基質として認識し，それらは不安定なo-キノンへと酸化される．生成したo-キノンはさらに，メラニンなどのポリマーへと変換される．o-キノンのいくつかは， …
NAID 130007399579

Purification and Characterization of Polyphenol Oxidase from Callus Cultures of Portulaca grandiflora

Yamamoto Ken-ichi,Yoshitama Kunijiro,Teramoto Susumu
Plant biotechnology 19(2), 95-101, 2002-06-01
… Three isoforms of polyphenol oxidase (I-a, I-b and II) were purified from betacyanin-producing callus cultures of Portulaca grandiflora, by ammonium sulfate precipitation followed by successive column chromatographies of DEAE cellulose, Sephacryl S-200, hydroxyapatite and Mono-Q. … The molecular masses of the monomeric polyphenol oxidase I-a and I-b were calculated to be 66 and 65 kDa, respectively, when analyzed by SDS-PAGE. …
NAID 130000064216

ACTIVATION AND MONOPHENOL HYDROXYLASE ACTIVITY OF POLYPHENOL OXIDASE IN SWEET POTATO SUSPENSION CULTURES

SUZUKI Keita,SHIOIRI Hidenari,KOJIMA Mineo,NOZUE Masayuki
Plant and cell physiology 38, s45, 1997-03
NAID 10004345552

「チロシナーゼ」

　　[★]

英: tyrosinase
同: モノフェノールモノオキシゲナーゼ monophenol monooxygenase、モノフェノールオキシダーゼ monophenol oxidase、フェノラーゼ phenolase

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案内

案内

monophenol oxidase

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「チロシナーゼ」