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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/20 11:16:02」(JST)

A monokine is a type of cytokine^[1] produced primarily by monocytes and macrophages.

Examples include interleukin 1 and tumor necrosis factor-alpha.

Other monokines include alpha and beta interferon, and colony stimulating factors.^[2]

Functions[edit]

Monokines released from macrophages can attract neutrophils, via the process chemotaxis.

^ Monokines at the US National Library of Medicine Medical Subject Headings (MeSH)
^ Julius M. Cruse; Robert Edwin Lewis (20 April 2009). Illustrated dictionary of immunology. CRC Press. pp. 208–. ISBN 978-0-8493-7987-1. Retrieved 24 April 2011.

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1. 免疫系におけるサイトカインの役割 role of cytokines in the immune system
2. 血液-血液透析膜の相互作用に関与する生化学的機序 biochemical mechanisms involved in blood hemodialysis membrane interactions
3. 壊死性軟部組織感染症 necrotizing soft tissue infections

Sulforaphane protects human chondrocytes against cell death induced by various stimuli.

Facchini A, Stanic I, Cetrullo S, Borzi RM, Filardo G, Flamigni F.SourceDipartimento di Biochimica G. Moruzzi, University of Bologna, Bologna, Italy.
Journal of cellular physiology.J Cell Physiol.2011 Jul;226(7):1771-9. doi: 10.1002/jcp.22506.
Chondrocyte cell death can contribute to cartilage degeneration in articular diseases, such as osteoarthritis (OA). Sulforaphane (SFN), a natural compound derived from cruciferous aliment, is well known as an anti-carcinogen, but according to recent evidence it also shows cytoprotective effects on a
PMID 21506109

Serum chemokine receptor CXCR3 ligands are associated with progression, organ dysfunction and complications of chronic liver diseases.

Tacke F, Zimmermann HW, Berres ML, Trautwein C, Wasmuth HE.SourceMedical Department III, University Hospital Aachen, Aachen, Germany.
Liver international : official journal of the International Association for the Study of the Liver.Liver Int.2011 Jul;31(6):842-51. doi: 10.1111/j.1478-3231.2011.02504.x. Epub 2011 Mar 10.
Background: Chemokines are chemotactic mediators that are implicated in liver diseases. In viral hepatitis and primary biliary cirrhosis, a predominant chemokine receptor expressed in the liver is CXCR3, suggesting that its specific ligands are important in the progression of chronic liver diseases
PMID 21645215

α-Viniferin Suppresses the Signal Transducer and Activation of Transcription-1 (STAT-1)–Inducible Inflammatory Genes in Interferon-γ–Stimulated Macrophages

Chung Eun Yong,Roh Eunmiri,Kwak Jeong-Ah,Lee Heun-Sik,Lee Seung Ho,Lee Chong-Kil,Han Sang-Bae,Kim Youngsoo
Journal of Pharmacological Sciences 112(4), 405-414, 2010
… 10 μM dose-dependently inhibited IFN-γ–induced production of NO, IFN-γ–inducible protein-10 (IP-10), or the monokine induced by IFN-γ (MIG) in RAW 264.7 cells and also that of NO in primary macrophages-derived from C57BL/6 mice. …
NAID 130000253380

Kuwano Yoshihiro,Fujimoto Manabu,Watanabe Rei,Asashima Nobuko,Nakashima Hiroko,Ohno Hiroki,Yano Shoichiro,Yazawa Norihito,Okochi Hitoshi,Tamaki Kunihiko
British Journal of Dermatology 157(3), 466-473, 2007-09
… Methods: Serum samples from 85 patients with AA, 20 patients with atopic dermatitis, 20 patients with psoriasis vulgaris and 28 normal controls were examined by the cytometric bead array assay assessing monokine induced by interferon (IFN)-γ (MIG), RANTES, interleukin-8 (IL-8), IFN-inducible protein-10, monocyte chemoattractant protein-1, macrophage inflammatory protein (MIP)-1α, MIP-1β and eotaxin levels. …
NAID 120001138122