ミノドロン酸
WordNet
- street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
- any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
- having the characteristics of an acid; "an acid reaction"
PrepTutorEJDIC
- 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/06/17 14:18:42」(JST)
[Wiki en表示]
Not to be confused with mildronate.
Minodronic acid |
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IUPAC name
(1-Hydroxy-2-imidazo[1,2-a]pyridin-3-yl-1-phosphonoethyl)phosphonic acid
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Identifiers |
CAS number |
180064-38-4 N, 155648-60-5 (hydrate) Y |
PubChem |
130956 |
ChemSpider |
115805 Y |
ChEMBL |
CHEMBL319144 Y |
Jmol-3D images |
Image 1 |
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O=P(O)(O)C(O)(P(=O)(O)O)Cc1cnc2ccccn12
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InChI=1S/C9H12N2O7P2/c12-9(19(13,14)15,20(16,17)18)5-7-6-10-8-3-1-2-4-11(7)8/h1-4,6,12H,5H2,(H2,13,14,15)(H2,16,17,18) Y
Key: VMMKGHQPQIEGSQ-UHFFFAOYSA-N Y
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Properties |
Molecular formula |
C9H12N2O7P2 |
Molar mass |
322.15 g mol−1 |
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) |
N (verify) (what is: Y/N?) |
Infobox references |
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Minodronic acid is a third-generation bisphosphonate drug. It is approved for use in Japan for the treatment of osteoporosis.[1] Its mechanism of action involves inhibition of farnesyl pyrophosphate synthase activity.[2]
References
- ^ Shridhar Hegde and Michelle Schmidt (2009). "To Market, To Market - 2009. 16. Minodronic acid". Annual Reports in Medicinal Chemistry 45: 509–510. doi:10.1016/s0065-7743(10)45028-9.
- ^ Sorbera, L.A.; Castañer, J.; Leeson, P.A. (2002). "Minodronic Acid". Drugs of the Future 27 (10): 935–941. doi:10.1358/dof.2002.027.10.701186.
UpToDate Contents
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English Journal
- Evaluation of crystallographic orientation of biological apatite in vertebral cortical bone in ovariectomized cynomolgus monkeys treated with minodronic acid and alendronate.
- Tanaka M1, Matsugaki A, Ishimoto T, Nakano T.
- Journal of bone and mineral metabolism.J Bone Miner Metab.2015 Apr 3. [Epub ahead of print]
- Quantitative analysis of the orientational distribution of biological apatite (BAp) crystals is proposed as a new index of bone quality. This study aimed to analyze BAp c-axis orientation in ovariectomized (OVX) monkeys treated with amino-bisphosphonates minodronic acid and alendronate as reference.
- PMID 25837430
- Pharmacokinetics and tolerability of minodronic Acid tablets in healthy chinese subjects and food and age effects on the pharmacokinetics.
- Zhou Y1, He X1, Li H1, Ni Y1, Xu M1, Sattar H1, Chen H2, Li W3.
- Clinical therapeutics.Clin Ther.2015 Apr 1;37(4):869-76. doi: 10.1016/j.clinthera.2015.01.015. Epub 2015 Mar 5.
- PURPOSE: Minodronic acid is a third-generation bisphosphonate being developed for the treatment of osteoporosis. The aim of this study was to evaluate the pharmacokinetic profiles and tolerability of minodronic acid in healthy subjects, as well as to assess the effects of food and age on the pharmac
- PMID 25748293
- Crystal structure of zwitterionic 3-(2-hy-droxy-2-phospho-nato-2-phosphono-eth-yl)imidazo[1,2-a]pyridin-1-ium monohydrate (minodronic acid monohydrate): a redetermination.
- Airoldi A1, Bettoni P1, Donnola M1, Calestani G2, Rizzoli C2.
- Acta crystallographica. Section E, Crystallographic communications.Acta Crystallogr E Crystallogr Commun.2015 Jan 1;71(Pt 1):51-4. doi: 10.1107/S2056989014026863. eCollection 2015.
- In a previous study, the X-ray structure of the title compound, C9H12N2O7P2·H2O, was reported [Takeuchi et al., (1998 ▶). Chem. Pharm. Bull. 46, 1703-1709], but neither atomic coordinates nor details of the geometry were published. The structure has been redetermined with high precision as its de
- PMID 25705449
Japanese Journal
- 経験と考察 原発性骨粗鬆症の橈骨骨密度に及ぼす新規ミノドロン酸水和物の効果の検討
- 佐藤 栄一,萩野 哲男,落合 聡司 [他]
- 整形外科 = Orthopedic surgery 65(4), 313-316, 2014-04
- NAID 40020027624
- 経験 新規ビスフォスフォネート製剤ミノドロン酸水和物の短期治療成績
- ミノドロン酸水和物と活性型ビタミンD3 併用療法により骨盤骨折修復および骨代謝改善を得た腎不全透析症例
- 森田 充浩,木村 昌芳,中島 由加里,大塚 明世,山田 治基
- 中部日本整形外科災害外科学会雑誌 56(5), 1209-1210, 2013
- NAID 130004144099
Related Links
- Find quality suppliers and manufacturers of Minodronic-Acidfor price inquiry.where to buy Minodronic-Acid.Also offer free database of Minodronic-Acid including MSDS sheet(poisoning, toxicity, hazards and safety),chemical ...
- Structure, properties, spectra, suppliers and links for: Minodronic acid, 127657-42-5. ... Predicted data is generated using the US Environmental Protection Agency’s EPISuite , for more information see their website. Log Octanol ...
★リンクテーブル★
[★]
- 英
- minodronic acid
- 化
- ミノドロン酸水和物 minodronic acid hydrate
- 商
- ボノテオ、リカルボン
- 関
- 他に分類されない代謝性医薬品
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ミノドロン酸水和物