WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
hormone that is one of the steroids of the adrenal cortex that influences the metabolism of sodium and potassium

PrepTutorEJDIC

=sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/24 18:13:35」(JST)

wiki en

The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2.^[1]

MR is a receptor with equal affinity for mineralocorticoids and glucocorticoids. It belongs to the nuclear receptor family where the ligand diffuses into cells, interacts with the receptor and results in a signal transduction affecting specific gene expression in the nucleus.

Function

MR is expressed in many tissues, such as the kidney, colon, heart, central nervous system (hippocampus), brown adipose tissue and sweat glands. In epithelial tissues, its activation leads to the expression of proteins regulating ionic and water transports (mainly the epithelial sodium channel or ENaC, Na+/K+ pump, serum and glucocorticoid induced kinase or SGK1) resulting in the reabsoprtion of sodium, and as a consequence an increase in extracellular volume, increase in blood pressure, and an excretion of potassium to maintain a normal salt concentration in the body.

The receptor is activated by mineralocorticoids such as aldosterone and deoxycorticosterone as well as glucocorticoids, like cortisol. In intact animals, the mineralocorticoid receptor is "protected" from glucocorticoids by co-localization of an enzyme, Corticosteroid 11-beta-dehydrogenase isozyme 2 (aka 11-β-hydroxysteroid dehydrogenase 2; 11ß-HSD2), that converts cortisol to inactive cortisone. It also responds to some progestins. Spironolactone and eplerenone are mineralocorticoid receptor antagonists.

Activation of the mineralocorticoid receptor, upon the binding of its ligand aldosterone, results in its translocation to the cell nucleus, homodimerization and binding to hormone response elements present in the promoter of some genes. This results in the complex recruitment of the transcriptional machinery and the transcription into mRNA of the DNA sequence of the activated genes.^[2]

Interactions

Mineralocorticoid receptor has been shown to interact with:

Glucocorticoid receptor^[3] and
TRIM24.^[3]^[4]^[5]

References

^ Fan YS, Eddy RL, Byers MG, Haley LL, Henry WM, Nowak NJ, Shows TB (1989). "The human mineralocorticoid receptor gene (MLR) is located on chromosome 4 at q31.2". Cytogenet. Cell Genet. 52 (1-2): 83–4. doi:10.1159/000132846. PMID 2558856.
^ Fuller PJ, Young MJ (2005). "Mechanisms of mineralocorticoid action". Hypertension 46 (6): 1227–35. doi:10.1161/01.HYP.0000193502.77417.17. PMID 16286565.
^ ^a ^b Savory, J G; Préfontaine G G, Lamprecht C, Liao M, Walther R F, Lefebvre Y A, Haché R J (Feb. 2001). "Glucocorticoid receptor homodimers and glucocorticoid-mineralocorticoid receptor heterodimers form in the cytoplasm through alternative dimerization interfaces". Mol. Cell. Biol. (UNITED STATES) 21 (3): 781–93. doi:10.1128/MCB.21.3.781-793.2001. ISSN 0270-7306. PMC 86670. PMID 11154266.
^ Zennaro MC, Souque A, Viengchareun S, Poisson E, Lombès M (September 2001). "A new human MR splice variant is a ligand-independent transactivator modulating corticosteroid action". Mol. Endocrinol. 15 (9): 1586–98. doi:10.1210/me.15.9.1586. PMID 11518808.
^ Thénot S, Henriquet C, Rochefort H, Cavaillès V (May 1997). "Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1". J. Biol. Chem. 272 (18): 12062–8. doi:10.1074/jbc.272.18.12062. PMID 9115274.

External links

Mineralocorticoid Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. Chapter 6C：アルドステロン chapter 6c aldosterone
2. 見かけの鉱質コルチコイド過剰（AME）症候群（長期甘草摂取を含む） apparent mineralocorticoid excess syndromes including chronic licorice ingestion
3. 原発性アルドステロン症の臨床的特徴 clinical features of primary aldosteronism
4. 慢性腎臓病の二次的要因と進行 secondary factors and progression of chronic kidney disease
5. 低カリウム血症を合併した高血圧症へのアプローチ approach to the patient with hypertension and hypokalemia

English Journal

Antidepressant-like effects of mineralocorticoid but not glucocorticoid antagonists in the lateral septum: interactions with the serotonergic system.

Mostalac-Preciado CR, de Gortari P, Lopez-Rubalcava C.SourceDept. CINVESTAV-IPN, Sede Sur, Calzada de los Tenorios No. 235, Col. Granjas Coapa, C.P. 14330, Mexico, D.F., Mexico. cm_qfb@msn.com
Behavioural brain research.Behav Brain Res.2011 Sep 30;223(1):88-98. Epub 2011 Apr 14.
The lateral septum (LS) is a limbic brain region that receives serotonergic projections from raphe neurons and participates in the modulation of stress responses and affective states. The present study determined whether mineralocorticoid receptors (MRs) and/or glucocorticoid receptors (GRs) located
PMID 21515309

Japanese Journal

SM-368229, a Novel Selective and Potent Non-steroidal Mineralocorticoid Receptor Antagonist With Strong Urinary Na+ Excretion Activity

Nariai Tetsuro,Fujita Katsuya,Mori Masaya,Katayama Seiji,Hori Seiji,Matsui Kazuki
Journal of Pharmacological Sciences 115(3), 346-353, 2011
… Mineralocorticoid receptor (MR) antagonists, such as spironolactone (SPI) and eplerenone (EPL), are useful for the treatment of hypertension and heart failure. …
NAID 130000663397

Related Pictures

★リンクテーブル★

リンク元	「鉱質コルチコイド受容体」「ミネラルコルチコイド受容体」「ミネラロコルチコイド受容体」「ミネラルコルチコイドレセプター」
関連記事	「mineralocorticoid」

「鉱質コルチコイド受容体」

Nuclear receptor subfamily 3, group C, member 2
	; PDB rendering based on 1gdc.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1Y9R, 1YA3, 2A3I, 2AA2, 2AA5, 2AA6, 2AA7, 2AAX, 2AB2, 2ABI, 2OAX, 3VHU, 3VHV
Identifiers
Symbols	NR3C2; MCR; MLR; MR; NR3C2VIT
External IDs	OMIM: 600983 MGI: 99459 HomoloGene: 121495 IUPHAR: NR3C2 ChEMBL: 1994 GeneCards: NR3C2 Gene
Gene Ontology
Molecular function	• sequence-specific DNA binding transcription factor activity; • steroid hormone receptor activity; • steroid binding; • protein binding; • zinc ion binding; • sequence-specific DNA binding; • metal ion binding;
Cellular component	• nucleoplasm; • endoplasmic reticulum membrane;
Biological process	• transcription initiation from RNA polymerase II promoter; • signal transduction; • gene expression;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;