"Microcephalus" redirects here. For the genus of beetle, see Microcephalus (genus).
| Microcephaly |
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A baby with microcephaly (left) compared to a baby with a typical head size
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| Classification and external resources |
| Specialty |
Medical genetics |
| ICD-10 |
Q02 |
| ICD-9-CM |
742.1 |
| OMIM |
251200 |
| DiseasesDB |
22629 |
| MedlinePlus |
003272 |
| MeSH |
D008831 |
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[edit on Wikidata]
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Microcephaly is a medical condition in which the brain does not develop properly resulting in a smaller than normal head.[1] Microcephaly may be present at birth or it may develop in the first few years of life.[1] Often people with the disorder have an intellectual disability, poor motor function, poor speech, abnormal facial features, seizures, and are short.[1]
The disorder may stem from a wide variety of conditions that cause abnormal growth of the brain, or from syndromes associated with chromosomal abnormalities. A homozygous mutation in one of the microcephalin genes causes primary microcephaly.[2] [3] It serves as an important neurological indication or warning sign, but no uniformity exists in its definition. It is usually defined as a head circumference (HC) more than two standard deviations below the mean for age and sex.[4][5] Some academics advocate defining it as head circumference more than three standard deviations below the mean for the age and sex.[6]
There is no specific treatment that returns the head size to normal.[1] In general, life expectancy for individuals with microcephaly is reduced and the prognosis for normal brain function is poor. Occasionally some will grow normally and develop normal intelligence.[1]
Contents
- 1 Signs and symptoms
- 2 Causes
- 2.1 Congenital
- 2.2 Postnatal onset
- 2.3 Microencephaly
- 2.4 Other
- 3 Treatment
- 4 History
- 5 Notable cases
- 6 See also
- 7 References
- 8 External links
Signs and symptoms
Affected newborns generally have striking neurological defects and seizures. Severely impaired intellectual development is common, but disturbances in motor functions may not appear until later in life.[citation needed]
Infants with microcephaly are born with either a normal or reduced head size. Subsequently, the head fails to grow, while the face continues to develop at a normal rate, producing a child with a small head and a receding forehead, and a loose, often wrinkled scalp. As the child grows older, the smallness of the skull becomes more obvious, although the entire body also is often underweight and dwarfed. Development of motor functions and speech may be delayed. Hyperactivity and intellectual disability are common occurrences, although the degree of each varies. Convulsions may also occur. Motor ability varies, ranging from clumsiness in some to spastic quadriplegia in others.[citation needed]
Causes
Neural scans of a normal-sized skull (left) and a case of microcephaly (right)
Microcephaly is a type of cephalic disorder. It has been classified in two types based on the onset:[7]
Congenital
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Isolated
- Familial (autosomal recessive) microcephaly
- Autosomal dominant microcephaly
- X-linked microcephaly
- Chromosomal (balanced rearrangements and ring chromosome)
Syndromes
- Poland syndrome
- Down syndrome
- Edward syndrome
- Patau syndrome
- Unbalanced rearrangements
- 4p deletion (Wolf–Hirschhorn syndrome)
- 5p deletion (Cri-du-chat)
- 7q11.23 deletion (Williams syndrome)
- 22q11 deletion (DiGeorge syndrome)
- Smith–Lemli–Opitz syndrome
- Seckel syndrome
- Cornelia de Lange syndrome
- Holoprosencephaly
- Primary microcephaly 4[8]
Acquired
- Ischemic stroke
- Hemorrhagic stroke
- Death of a monozygotic twin
- Vertically transmitted infections
- Congenital cytomegalovirus infection
- Toxoplasmosis
- Congenital rubella syndrome
- Zika virus is a suspected cause[9][10][11]
- Fetal hydantoin syndrome
- Fetal alcohol syndrome
Other
- Radiation exposure to mother
- Maternal malnutrition
- Maternal phenylketonuria
- Poorly controlled gestational diabetes
- Hyperthermia
- Maternal hypothyroidism
- Placental insufficiency
Postnatal onset
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This section needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (February 2016) |
Genetic
- Inborn errors of metabolism
- Congenital disorder of glycosylation
- Mitochondrial disorders
- Peroxisomal disorder
- Glucose transporter defect
- Menkes disease
- Congenital disorders of amino acid metabolism
- Organic acidemia
Syndromes
- 17p13.3 deletion (Miller–Dieker syndrome)
- Rett syndrome (primarily girls)
- Nijmegen breakage syndrome
- X-linked lissencephaly with abnormal genitalia
- Aicardi–Goutières syndrome
- Ataxia telangiectasia
- Cohen syndrome
- Cockayne syndrome
Acquired
- Traumatic brain injury
- Hypoxic-ischemic encephalopathy
- Ischemic stroke
- Hemorrhagic stroke
- Congenital HIV encephalopathy
- Meningitis
- Encephalitis
- Lead poisoning
- Chronic renal failure
- Hypothyroidism
- Anemia
- Congenital heart disease
- Malnutrition
A genetic factor may play a role in causing some cases of microcephaly. Relationships have been found between autism, duplications of chromosomes, and macrocephaly on one side. On the other side, a relationship has been found between schizophrenia, deletions of chromosomes, and microcephaly.[12][13][14] Moreover, an association has been established between common genetic variants within known microcephaly genes (MCPH1, CDK5RAP2) and normal variation in brain structure as measured with magnetic resonance imaging (MRI)—i.e., primarily brain cortical surface area and total brain volume.[15]
The spread of mosquito-borne Zika virus has been implicated in increasing levels of congenital microcephaly by the International Society for Infectious Diseases,[16] and the US Centers for Disease Control and Prevention.[17][18]
Microencephaly
"Microcephaly" means "smallheadedness" (New Latin microcephalia, from Ancient Greek μικρός mikrós "small" and κεφαλή kephalé "head"[19]). "Microencephaly" means "small brain". Because the size of the head is mostly determined by the size of the brain, microencephaly is implied when discussing microcephaly.[20]
Other
After the dropping of atomic bombs "Little Boy" on Hiroshima and "Fat Man" on Nagasaki, several women close to ground zero who had been pregnant at the time gave birth to children with microcephaly.[21] Microcephaly prevalence was seven of a group of 11 pregnant women at 11–17 weeks of gestation who survived the blast at less than 1.2 km (0.75 mi) from ground zero. Due to their proximity to the bomb, the pregnant women's in utero children received a biologically significant radiation dose that was relatively high due to the massive neutron output of the lower explosive-yielding Little Boy.[22] Microcephaly is the only proven malformation, or congenital abnormality, found in the children of Hiroshima and Nagasaki.[22]
Treatment
There is no cure for microcephaly.[1] Treatment is symptomatic and supportive.[1]
History
People with microcephaly were sometimes sold to freak shows in North America and Europe in the 19th and early 20th centuries, where they were known by the name "pinheads". Many of them were presented as different species (e.g., "monkey man") and described as being the missing link.[23] Famous examples are Zip the Pinhead (although he may not have had microcephaly)[24] and Schlitzie the Pinhead,[25] who also starred in the 1932 movie Freaks. Both these individuals were cited as influences on the development of the long-running comic strip character Zippy the Pinhead, created by Bill Griffith.[26]
Notable cases
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This section does not cite any sources. Please help improve this section by adding citations to reliable sources. Unsourced material may be challenged and removed. (February 2016) |
- Triboulet was a jester of duke René of Anjou (not to be confused with the slightly later Triboulet at the French court).
- Jenny Lee Snow and Elvira Snow, commonly referred to as Pip and Flip, were sisters with microcephaly who acted in the 1932 film Freaks.
- Schlitze "Schlitzie" Surtees, possibly born Simon Metz, was a sideshow performer and actor.
- Lester "Beetlejuice" Napoleon Green, known on the Howard Stern Show for being "The Greatest Wack Packer of All Time"
See also
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Human rights portal |
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Medicine portal |
- Anencephaly
- Hydrocephaly
- Macrocephaly
- Seckel syndrome
References
- ^ a b c d e f g "NINDS Microcephaly Information Page". NINDS. June 30, 2015. Retrieved 11 March 2016.
- ^ Jackson, Andrew P.; Eastwood, Helen; Bell, Sandra M.; Adu, Jimi; Toomes, Carmel; Carr, Ian M.; Roberts, Emma; Hampshire, Daniel J.; et al. (2002). "Identification of Microcephalin, a Protein Implicated in Determining the Size of the Human Brain". The American Journal of Human Genetics 71 (1): 136–42. doi:10.1086/341283. PMC 419993. PMID 12046007.
- ^ Jackson, Andrew P.; McHale, Duncan P.; Campbell, David A.; Jafri, Hussain; Rashid, Yasmin; Mannan, Jovaria; Karbani, Gulshan; Corry, Peter; et al. (1998). "Primary Autosomal Recessive Microcephaly (MCPH1) Maps to Chromosome 8p22-pter". The American Journal of Human Genetics 63 (2): 541–6. doi:10.1086/301966. PMC 1377307. PMID 9683597.
- ^ Leviton, A.; Holmes, L. B.; Allred, E. N.; Vargas, J. (2002). "Methodologic issues in epidemiologic studies of congenital microcephaly". Early Hum Dev 69 (1): 91–105. doi:10.1016/S0378-3782(02)00065-8.
- ^ Opitz, J. M.; Holt, M. C. (1990). "Microcephaly: general considerations and aids to nosology". J Craniofac Genet Dev Biol 10 (2): 75–204. PMID 2211965.
- ^ Behrman, R. E.; Kligman, R. M.; Jensen, H. B. (2000). Nelson's Textbook of Pediatrics (16th ed.). Philadelphia: WB Saunders. ISBN 0721677673.
- ^ Ashwal, S.; Michelson, D.; Plawner, L.; Dobyns, W. B. (2009). "Practice Parameter: Evaluation of the child with microcephaly (an evidence-based review)". Neurology 73 (11): 887–897. doi:10.1212/WNL.0b013e3181b783f7.
- ^ Szczepanski S, Hussain MS Sur I, Altmüller J, Thiele H, Abdullah U, Waseem SS, Moawia A, Nürnberg G, Noegel AA, Baig SM, Nürnberg P (2015) A novel homozygous splicing mutation of CASC5 causes primary microcephaly in a large Pakistani family. Hum Genet
- ^ Emily E. Petersen, Erin Staples, Dana Meaney-Delman, Marc Fischer, Sascha R. Ellington, William M. Callaghan, Denise J. Jamieson (January 22, 2016). "Interim Guidelines for Pregnant Women During a Zika Virus Outbreak — United States, 2016". www.cdc.gov/mmwr. MMWR Early Release on the MMWR website. pp. 30–33.
- ^ Lavinia Schuler-Faccini, Erlane M. Ribeiro, Ian M.L. Feitosa, Dafne D.G. Horovitz, Denise P. Cavalcanti, André Pessoa, Maria Juliana R. Doriqui, Joao Ivanildo Neri, Joao Monteiro de Pina Neto, Hector Y.C. Wanderley, Mirlene Cernach, Antonette S. El-Husny, Marcos V.S. Pone, Cassio L.C. Serao, Maria Teresa V. Sanseverin. Possible Association Between Zika Virus Infection and Microcephaly — Brazil, 2015. 2016 (Jan 29) Morbidity and Mortality Weekly Report (MMWR) 2016 / 65(3);59–62.
- ^ European Centre for Disease Prevention and Control. Rapid risk assessment: Microcephaly in Brazil potentially linked to the Zika virus epidemic – 24 November 2015. Stockholm: ECDC; 2015. (Associated press release "Microcephaly in Brazil potentially linked to the Zika virus epidemic, ECDC assesses the risk")
- ^ Crespi B, Stead P, Elliot M; Stead; Elliot (January 2010). "Evolution in health and medicine Sackler colloquium: Comparative genomics of autism and schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 107 (Suppl 1): 1736–41. Bibcode:2010PNAS..107.1736C. doi:10.1073/pnas.0906080106. PMC 2868282. PMID 19955444.
- ^ Stone, Jennifer L.; o’Donovan, Michael C.; Gurling, Hugh; Kirov, George K.; Blackwood, Douglas H. R.; Corvin, Aiden; Craddock, Nick J.; Gill, Michael; Hultman, Christina M.; Lichtenstein, Paul; McQuillin, Andrew; Pato, Carlos N.; Ruderfer, Douglas M.; Owen, Michael J.; St Clair, David; Sullivan, Patrick F.; Sklar, Pamela; Purcell (Leader), Shaun M.; Stone, Jennifer L.; Ruderfer, Douglas M.; Korn, Joshua; Kirov, George K.; MacGregor, Stuart; McQuillin, Andrew; Morris, Derek W.; O’Dushlaine, Colm T.; Daly, Mark J.; Visscher, Peter M.; Holmans, Peter A.; et al. (September 2008). "Rare chromosomal deletions and duplications increase risk of schizophrenia". Nature 455 (7210): 237–41. Bibcode:2008Natur.455..237S. doi:10.1038/nature07239. PMC 3912847. PMID 18668038.
- ^ Dumas L, Sikela JM (2009). "DUF1220 domains, cognitive disease, and human brain evolution". Cold Spring Harb. Symp. Quant. Biol. 74: 375–82. doi:10.1101/sqb.2009.74.025. PMC 2902282. PMID 19850849.
- ^ Rimol, Lars M.; Agartz, Ingrid; Djurovic, Srdjan; Brown, Andrew A.; Roddey, J. Cooper; Kahler, Anna K.; Mattingsdal, Morten; Athanasiu, Lavinia; et al. (2010). "Sex-dependent association of common variants of microcephaly genes with brain structure". Proceedings of the National Academy of Sciences 107 (1): 384–8. Bibcode:2010PNAS..107..384R. doi:10.1073/pnas.0908454107. JSTOR 40536283. PMC 2806758. PMID 20080800.
- ^ "Zika virus - Brazil: confirmed Archive Number: 20150519.3370768". Pro-MED-mail. International Society for Infectious Diseases.
- ^ "CDC issues interim travel guidance related to Zika virus for 14 Countries and Territories in Central and South America and the Caribbean". Centers for Disease Control and Prevention. 2016-01-15. Retrieved 2016-01-17.
- ^ Beth Mole (2016-01-17). "CDC issues travel advisory for 14 countries with alarming viral outbreaks]". Ars Technica. Condé Nast. Retrieved 2016-01-17.
- ^ "Microcephaly - Definition of Microcephaly by Merriam-Webster".
- ^ David D. Weaver; Ira K. Brandt (1999). Catalog of prenatally diagnosed conditions. JHU Press. p. 104. ISBN 978-0-8018-6044-7. Retrieved 25 March 2012.
- ^ "Aftereffects".
- ^ a b "Teratology in the Twentieth Century Plus Ten".
- ^ Mateen FJ, Boes CJ (2010). "‘Pinheads’: the exhibition of neurologic disorders at ‘The Greatest Show on Earth’". Neurology 30 (22): 2028–32. doi:10.1212/WNL.0b013e3181ff9636. PMID 21115959.
- ^ "[1]?" 16 October 2010.
- ^ "[2]?" 16 October 2010.
- ^ Interview with Bill Griffith, Goblin Magazine 1995, transcribed on zippythepinhead.com; accessed Feb. 13, 2013
External links
- Microcephaly at NINDS
- Microcephaly Support Group
- The Rat People of Pakistan
- NINDS Overview
- Schlitzie The Pinhead
- Head circumference percentile calculator
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Congenital malformations and deformations of nervous system (Q00–Q07, 740–742)
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| Brain |
| Neural tube defect |
- Anencephaly
- Acephaly
- Acrania
- Acalvaria
- Iniencephaly
- Encephalocele
- Arnold–Chiari malformation
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| Other |
- Microcephaly
- Congenital hydrocephalus
- other reduction deformities
- Holoprosencephaly
- Lissencephaly
- Pachygyria
- Hydranencephaly
- Septo-optic dysplasia
- Megalencephaly
- CNS cyst
- Porencephaly
- Schizencephaly
- Polymicrogyria
- Bilateral frontoparietal polymicrogyria
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| Spinal cord |
| Neural tube defect |
- Spina bifida
- Rachischisis
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| Other |
- Currarino syndrome
- Diastomatomyelia
- Syringomyelia
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