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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/09 19:19:46」(JST)

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1. 変形性関節症の初回薬物療法 initial pharmacologic therapy of osteoarthritis
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Quantitative analysis of methacycline hydrochloride by direct potentiometry using the internal solid contact sensor.

Sun XX1, Aboul-Enein HY.Author information 1Department of Chemical Engineering, Jiangsu Polytechnic University, Changzhou, PR China. sunxxiang@sohu.comAbstractAn internal solid contact sensor (ISCS) for the determination of methacycline hydrochloride (MC.Cl), Pt/PPy/PVC(MC-PT), is described, based on the use of conducting poly(pyrrole) (PPy) as solid contact material and MC-phosphotungstate (PT) as the ion exchanger and dibutyl phthalate (DBP) as the plasticizer. A direct potentiometric method for the quantitative analysis of MC.Cl is also described. Under the condition of pH 2.7, the linear concentration range, slope (25 degrees C) and detection limit of the sensor are 6.4 x 1.0(-6) - 3.0 x 1.0(-3) M, 52.4 +/- 0.2 mV/decade and 4.4 x 1.0(-6) M, respectively. The response time is <5 s. The determinations of MC.Cl in tablets were carried out by direct potentiometry. The average recovery and relative standard deviation are 100.1 and 0.7% (n = 4), respectively.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.Anal Sci.2007 Feb;23(2):231-3.
An internal solid contact sensor (ISCS) for the determination of methacycline hydrochloride (MC.Cl), Pt/PPy/PVC(MC-PT), is described, based on the use of conducting poly(pyrrole) (PPy) as solid contact material and MC-phosphotungstate (PT) as the ion exchanger and dibutyl phthalate (DBP) as the plas
PMID 17297239

Stability of tetracycline antibiotics in raw milk under laboratory storage conditions.

Podhorniak LV1, Leake S, Schenck FJ.Author information 1U.S. Food and Drug Administration, Baltimore District Laboratory, MD 21201, USA.AbstractRaw milk samples collected from bulk milk tankers may be screened for the presence of tetracycline antibiotics using rapid screening tests. If tetracycline residues are detected, the milk may be shipped to a laboratory for high-pressure liquid chromatography (HPLC) analysis. Because the milk may be shipped on ice blocks, it is important to know whether tetracycline residues are stable at that temperature and for how long. Control raw milk samples fortified with 50 ppb each chlortetracycline, demeclocycline, methacycline hydrochloride, minocycline, oxytetracycline, and tetracycline were incubated at 4 degrees C or 25 degrees C, then analyzed using a metal chelate affinity chromatography extraction and HPLC. No loss of tetracycline was observed after 48 h of storage at 4 degrees C or 24 h at 25 degrees C. Losses ranging from 4 to 13% and 0 to 18% were noted after 72 h at 4 degrees C and 48 h at 25 degrees C, respectively.
Journal of food protection.J Food Prot.1999 May;62(5):547-8.
Raw milk samples collected from bulk milk tankers may be screened for the presence of tetracycline antibiotics using rapid screening tests. If tetracycline residues are detected, the milk may be shipped to a laboratory for high-pressure liquid chromatography (HPLC) analysis. Because the milk may be
PMID 10340680

Spectrophotometric determination of tetracyclines in pharmaceutical preparations, with uranyl acetate.

Saha U1, Sen AK, Das TK, Bhowal SK.Author information 1Central Public Health & Drug Laboratory, 2 Convent Lane, Calcutta 700016, India.AbstractUranyl acetate is proposed as a reagent for the spectrophotometric determination of the tetracycline group of antibiotics. The reagent forms orange-red 1:1 complexes with the drugs in N,N-dimethylformamide medium. The complexes show absorption maxima at 414, 406, 419, 405 and 402 nm for tetracycline hydrochloride (TCH), oxytetracycline hydrochloride (OTCH), chlortetracycline hydrochloride (CTCH), doxycycline hydrochloride (DCH) and methacycline hydrochloride (MCH), respectively. Beer's law is valid over the concentration ranges 0-115, 0-120, 0-125, 0-135 and 0-110 microg/ml for TCH, OTCH, CTCH, DCH and MCH, respectively.
Talanta.Talanta.1990 Dec;37(12):1193-6.
Uranyl acetate is proposed as a reagent for the spectrophotometric determination of the tetracycline group of antibiotics. The reagent forms orange-red 1:1 complexes with the drugs in N,N-dimethylformamide medium. The complexes show absorption maxima at 414, 406, 419, 405 and 402 nm for tetracycline
PMID 18965095

Quantitative Analysis of Methacycline Hydrochloride by Direct Potentiometry Using the Internal Solid Contact Sensor

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 23(2), 231-233, 2007-02-10
NAID 10018497812

Effect of antacids on the dissolution behavior of tetracycline and methacycline.

Metacycline
Systematic (IUPAC) name
	(2Z,4S,4aR,5S,5aR,12aS)-2-[amino(hydroxy)methylene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylene-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a682778
Identifiers
CAS Number	914-00-1
ATC code	J01AA05 (WHO)
PubChem	CID 5281054
ChemSpider	10468596
UNII	IR235I7C5P
ChEMBL	CHEMBL249837
NIAID ChemDB	001301
Chemical data
Formula	C22H22N2O8
Molar mass	442.419 g/mol
	SMILES NC(=O)C=3C(=O)[C@@]4(O)C(\O)=C2\C(=O)c1c(O)cccc1C(=C)[C@H]2[C@H](O)[C@H]4[C@H](N(C)C)C=3O ;
	InChI InChI=1S/C22H22N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-6,10,14-15,17,25,27-29,32H,1H2,2-3H3,(H2,23,31)/t10-,14-,15+,17+,22+/m1/s1 ; Key:MHIGBKBJSQVXNH-IWVLMIASSA-N ;
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