menin

メニン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/12/07 19:27:31」(JST)

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Menin may refer to:

• Menin, the French name for the Belgian town of Menen
• Menin, a little village in the municipality of Cesiomaggiore, Italy
• Menin or MEN1, a tumor suppressor associated with multiple endocrine neoplasia type 1
• Měnín, village and municipality in the Czech Republic
• Menin (title), office in Ancien Régime France

See also

• Menin Gate, a war memorial in Ypres, Belgium
• Menin Gate at Midnight, a 1927 painting by Australian artist Will Longstaff

UpToDate Contents

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• 1. 多発性内分泌腫瘍1型：定義および遺伝学multiple endocrine neoplasia type 1 definition and genetics [show details]
  …(11q13). Its protein product is termed "menin." Over 1000 MEN1 gene mutations have been detected that inactivate or disrupt menin function. Inactivation of menin results in loss of tumor suppression. Families …
• 2. 原発性副甲状腺機能亢進症の発症機序および病因pathogenesis and etiology of primary hyperparathyroidism [show details]
  …proportions were 12 to 13 percent . The mechanism by which the MEN1 gene product, a protein termed menin, functions normally and in tumorigenesis remains an active area of investigation. CDKN1B encodes…
• 3. 副甲状腺ホルモンの分泌および作用parathyroid hormone secretion and action [show details]
  …decade, particularly in familial forms of hyperparathyroidism. Some examples are genetic defects in menin (in multiple endocrine neoplasia 1 [MEN1] and adenomas), parafibromin (in sporadic and familial parathyroid…
• 4. ガストリンの生理学physiology of gastrin [show details]
  …requires not only hypergastrinemia but another cofactor, such as loss of the tumor suppressor gene, menin (the genetic defect in MEN-1), or overexpression of a tumor growth promoter such as BCL-2, which occurs…
• 5. 下垂体巨人症pituitary gigantism [show details]
  …setting of multiple endocrine neoplasia type 1 (MEN1) is attributed to mutations in the gene encoding menin, a nuclear protein that is expressed in multiple tissues. Germline mutations in CDKN1B (cyclin-dependent…

English Journal

• Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong Antitumor Activity.

• Xu S, Aguilar A, Huang L, Xu T, Zheng K, McEachern D, Przybranowski S, Foster C, Zawacki K, Liu Z, Chinnaswamy K, Stuckey J, Wang S.
• Journal of medicinal chemistry. 2020 May;63(9)4997-5010.
• Targeting the menin-MLL protein-protein interaction is a new therapeutic strategy for the treatment of acute leukemia carrying MLL fusion (MLL leukemia). We describe herein the structure-based optimization of a class of covalent menin inhibitors, which led to the discovery of M-808 () as a highly po
• PMID 32338903

• Clues for genetic anticipation in Multiple Endocrine Neoplasia type 1.

• van den Broek MFM, van Nesselrooij BPM, Pieterman CCR, Verrijn Stuart AA, van de Ven AC, de Herder WW, Dekkers OM, Drent ML, Havekes B, Kerstens MN, Bisschop PH, Valk GD.
• The Journal of clinical endocrinology and metabolism. 2020 May;().
• Multiple Endocrine Neoplasia type 1 (MEN1) is a rare autosomal dominant hereditary disease caused by loss-of-function of the MEN1 gene, a tumor suppressor gene encoding for the protein menin. It is characterized by the occurrence of primary hyperparathyroidism (pHPT), duodenopancreatic neuroendocrin
• PMID 32396602

• c-MET Inhibition: Novel Treatment for Sporadic and MEN1-associated GEP NET.

• Lee ME, Tepede AA, Mandl A, Weinstein LS, Del Rivero J, Agarwal SK, Blau JE.
• Journal of molecular endocrinology. 2020 May;().
• Gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) comprise a heterogenous and diverse group of neoplasms arising from a common neuroendocrine cell origin. The majority of these tumors occur sporadically while ~20% manifest within the context of hereditary syndromes. Germline MEN1 mutations c
• PMID 32384260

Japanese Journal

• 術前化学療法中にRamsay Hunt症候群を発症し，播種性帯状疱疹・髄膜脳炎へ重症化をきたした進行食道癌の1例

• 上月 亮太郎,古川 恵一,渡邊 雅之,峯 真司,山下 公太郎,大串 大輔,佐々木 俊治,岡村 明彦,湯田 匡美,速水 克,今村 裕
• 日本外科感染症学会雑誌 16(2), 136-139, 2019
• <p>水痘帯状疱疹は varicella zoster virusによる感染症であり，日常診療で比較的よく遭遇する。今回，進行食道癌に対する術前化学療法中に Ramsay Hunt症候群を発症し，播種性帯状疱疹・髄膜脳炎へと重症化した 1例を経験したので報告する。症例は 70歳代の女性。胸部食道癌cT3N1M0，Stage Ⅲの診断で術前化学療法を受けた。術前化学療法2コース目の 9日 …
• NAID 130007687035

• 教育講演 T細胞老化と慢性炎症

• 山下 政克
• 日本体質医学会雑誌 = The Japanese journal of constitutional medicine 80(2), 126-131, 2018-06
• NAID 40021613022

• 台湾男性との結婚を選択したインドネシア女性 : 結婚と行為主体性に関する人類学的試論 (清水真一教授退任記念号 国松夏紀教授退任記念号 GONZALEZ Dario教授退任記念号)

• 小池 誠,徐 幼恩
• 人間文化研究 = Journal of humanities research, St. Andrew's University (8), 187-216, 2018-02
• … The aim is to analyzethe life histories told by four Indonesian women who married Taiwanese menin the city of Kaohsiung, Taiwan, and to discuss how they decided to marry interms of women's agency. …
• NAID 120006461004

Related Links

• 【楽天市場】代官山のキッズ・レディースセレクトショップ ...

[トップページ]へようこそ。 【1/25 ivory, ice gray, ramune再入荷しました】menina イブル cloud petit ベビーイブル 約70×100 価格 2,500円(税込)

• GRJ 多発性内分泌腫瘍症1型

MeninのJunD結合ドメインに影響を与えるMEN1変異があると死亡リスクが2倍高いという報告がある[Thevenonら2013]（分子遺伝学の項参照）．Thevenonらの別の報告（2015）では，遺伝的関連が小さくなるとともに下垂体腫瘍，副腎

• Menin-Bach2経路はCD4 T細胞の老化とサイトカイン恒常性の ...

Menin-Bach2経路はCD4 T細胞の老化とサイトカイン恒常性の制御に重要である The Menin–Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis 2014年4月2日 Nature Communications 5: 3555 doi: 10.1038/ncomms4555

Related Pictures

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★リンクテーブル★

リンク元	「メニン」
拡張検索	「serogroup C meningococci」「cytomegalovirus meningitis」
関連記事	「men」

「メニン」

　　[★]

英

menin

関

家族性多発性内分泌腺腫症1型 MEN-1

「serogroup C meningococci」

　　[★]

血清型C株髄膜炎菌、C群血清型髄膜炎菌、セログループC髄膜炎菌

関

serogroup C meningococcus、serogroup C Neisseria meningitidis

「cytomegalovirus meningitis」

　　[★] サイトメガロウイルス髄膜炎

「men」

　　[★]

男性

関

male、male sex、man