malonate-semialdehyde dehydrogenase

マロン酸セミアルデヒド脱水素酵素、マロン酸セミアルデヒドデヒドロゲナーゼ

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/03/02 19:51:36」(JST)

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Malonate-semialdehyde dehydrogenase
Identifiers
EC number	1.2.1.15
CAS number	9028-94-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, a malonate-semialdehyde dehydrogenase (EC 1.2.1.15) is an enzyme that catalyzes the chemical reaction

3-oxopropanoate + NAD(P)+ + H₂O malonate + NAD(P)H + 2 H⁺

The 4 substrates of this enzyme are 3-oxopropanoate, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are malonate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-oxopropanoate:NAD(P)+ oxidoreductase. This enzyme participates in beta-alanine metabolism.

References

• Nakamura K and Bernheim F (1961). "Studies on malonic semialdehyde dehydrogenase from Pseudomonas aeruginosa". Biochim. Biophys. Acta 50: 147–152. doi:10.1016/0006-3002(61)91071-X. PMID 13727610. 

UpToDate Contents

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• 1. Diagnosis and management of glucose-6-phosphate dehydrogenase deficiency
• 2. 乳酸脱水素酵素欠損症 lactate dehydrogenase deficiency
• 3. ヘキソースリン酸側路およびグルタチオン代謝疾患（グルコース-6-リン酸脱水素酵素欠損症を除く） disorders of the hexose monophosphate shunt and glutathione metabolism other than glucose 6 phosphate dehydrogenase deficiency
• 4. 脂質およびプリン代謝障害による代謝性ミオパチー metabolic myopathies caused by disorders of lipid and purine metabolism
• 5. グルコース-6-リン酸脱水素酵素欠損症の遺伝学および病態生理 genetics and pathophysiology of glucose 6 phosphate dehydrogenase deficiency

English Journal

• Molecular dissection of bacterial acrylate catabolism--unexpected links with dimethylsulfoniopropionate catabolism and dimethyl sulfide production.

• Todd JD, Curson AR, Nikolaidou-Katsaraidou N, Brearley CA, Watmough NJ, Chan Y, Page PC, Sun L, Johnston AW.SourceSchool of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
• Environmental microbiology.Environ Microbiol.2010 Feb;12(2):327-43. Epub 2009 Oct 5.
• A bacterium in the genus Halomonas that grew on dimethylsulfoniopropionate (DMSP) or acrylate as sole carbon sources and that liberated the climate-changing gas dimethyl sulfide in media containing DMSP was obtained from the phylloplane of the macroalga Ulva. We identified a cluster that contains ge
• PMID 19807777

• Phenylpyruvate tautomerase activity of trans-3-chloroacrylic acid dehalogenase: evidence for an enol intermediate in the dehalogenase reaction?

• Poelarends GJ, Johnson WH Jr, Serrano H, Whitman CP.SourceDepartment of Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
• Biochemistry.Biochemistry.2007 Aug 21;46(33):9596-604. Epub 2007 Jul 28.
• The enzymatic conversion of cis- or trans-3-chloroacrylic acid to malonate semialdehyde is a key step in the bacterial degradation of the nematocide 1,3-dichloropropene. Two mechanisms have been proposed for the isomer-specific hydrolytic dehalogenases, cis- and trans-3-chloroacrylic acid dehalogena
• PMID 17661448

Japanese Journal

• Succinate-semialdehyde Dehydrogenase for L-Arginine and Putrescine Degradation in Brevibacterium helvolum(Microbiology & Fermentation Industry)

• YORIFUJI Takamitsu,INAGAKI Naofumi,SHIMIZU Eiichi,NAGASHIMA Tadashi
• Agricultural and Biological Chemistry 55(1), 215-220, 1991-01-23
• … Succinate-semialdehyde dehydrogenase (EC 1.2.1.16) was purified to apparent homogeneity from L-arginine-grown cells of Brevibacterium helvolum IFO 12073 (ATCC 11822). … The apparent Michaelis constant (Km) for succinate-semialdehyde was approximately 30μ_M. … Malonate-semialdehyde and other aldehydes tested were inert as substrates. …
• NAID 110006325197

Related Links

• malonate-semialdehyde dehydrogenase - definition of ...

ALDH6A1 ALDH6A1 A gene on chromosome 14q24.3 that encodes a mitochondrial methylmalonate semialdehyde dehydrogenase, an aldehyde dehydrogenase, which is involved in valine and pyrimidine catabolism. It causes the ...

• Malonate-semialdehyde dehydrogenase [acylating] - definition ...

ALDH6A1 ALDH6A1 A gene on chromosome 14q24.3 that encodes a mitochondrial methylmalonate semialdehyde dehydrogenase, an aldehyde dehydrogenase, which is involved in valine and pyrimidine catabolism. It causes the ...

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★リンクテーブル★

リンク元	「マロン酸セミアルデヒド脱水素酵素」「マロン酸セミアルデヒドデヒドロゲナーゼ」
拡張検索	「methylmalonate-semialdehyde dehydrogenase」
関連記事	「malonate」「dehydrogenase」「dehydrogenases」

「マロン酸セミアルデヒド脱水素酵素」

　　[★]

英

malonate-semialdehyde dehydrogenase

関

マロン酸セミアルデヒドデヒドロゲナーゼ

「マロン酸セミアルデヒドデヒドロゲナーゼ」

　　[★]

英

malonate-semialdehyde dehydrogenase

関

マロン酸セミアルデヒド脱水素酵素

「methylmalonate-semialdehyde dehydrogenase」

　　[★]

メチルマロン酸セミアルデヒド脱水素酵素

「malonate」

　　[★]

マロン酸、マロン酸塩、マロン酸エステル

関

malonic acid

• malonic acid

「dehydrogenase」

　　[★] 脱水素酵素 デヒドロゲナーゼ

「dehydrogenases」

　　[★] 脱水素酵素 デヒドロゲナーゼ