WordNet

a decrease in size of an organ caused by disease or disuse (同)wasting, wasting away
undergo atrophy; "Muscles that are not used will atrophy"
any weakening or degeneration (especially through lack of use) (同)withering
a small yellowish central area of the retina that is rich in cones and that mediates clear detailed vision (同)macula_lutea, macular_area, yellow_spot

PrepTutorEJDIC

(栄養不良などによる)萎縮(いしゅく) / (一般的に)衰退,退化 / 萎縮する,衰退する / …'を'萎縮させる,衰退させる

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/04/10 14:43:09」(JST)

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Anetoderma (also known as "Anetoderma maculosa,"^[1] "Anetoderma maculosa cutis,"^[1] "Atrophia maculosa cutis,"^[1] and "Macular atrophy"^[2]) is a localized laxity of the skin with herniation or outpouching resulting from abnormal dermal elastic tissue.^[2]

References

^ ^a ^b ^c Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
^ ^a ^b Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). Page 1027. McGraw-Hill. ISBN 0071380760.

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1. 加齢黄斑変性：治療および予防 age related macular degeneration treatment and prevention
2. 脊髄性筋萎縮症 spinal muscular atrophy
3. 脊髄小脳変性症 the spinocerebellar ataxias
4. 多系統萎縮症：予後および治療 multiple system atrophy prognosis and treatment
5. 加齢黄斑変性：臨床像、病因、および診断 age related macular degeneration clinical presentation etiology and diagnosis

English Journal

Paracentral acute middle maculopathy spectral-domain optical coherence tomography feature of deep capillary ischemia.

Rahimy E1, Sarraf D.Author information 1aMid Atlantic Retina, The Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania bJules Stein Eye Institute, UCLA cGreater LA VA Healthcare Center, Los Angeles, California, USA.AbstractPURPOSE OF REVIEW: To describe the novel spectral-domain optical coherence tomography (SD-OCT) finding of paracentral acute middle maculopathy (PAMM) that can be associated with acute macular neuroretinopathy (AMN) or retinal vasculopathy, and that may indicate an underlying pathogenesis related to ischemia of the retinal deep capillary plexus (DCP).
Current opinion in ophthalmology.Curr Opin Ophthalmol.2014 May;25(3):207-12. doi: 10.1097/ICU.0000000000000045.
PURPOSE OF REVIEW: To describe the novel spectral-domain optical coherence tomography (SD-OCT) finding of paracentral acute middle maculopathy (PAMM) that can be associated with acute macular neuroretinopathy (AMN) or retinal vasculopathy, and that may indicate an underlying pathogenesis related to
PMID 24614148

Choroidal Changes Associated with Bruch Membrane Pathology in Pseudoxanthoma Elasticum.

Gliem M1, Fimmers R2, Müller PL1, Brinkmann CK1, Finger RP3, Hendig D4, Holz FG1, Issa PC5.Author information 1Department of Ophthalmology, University of Bonn.2Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.3Department of Ophthalmology, University of Bonn; Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Australia.4Institute for Laboratory and Transfusion Medicine, Heart and Diabetes Center North Rhine-Westphalia, University Hospital of the Ruhr University of Bochum, Bad Oeynhausen, Germany.5Department of Ophthalmology, University of Bonn. Electronic address: peter.issa@ukb.uni-bonn.de.AbstractPURPOSE: To investigate the impact of Bruch Membrane pathology on the choroid in Pseudoxanthoma elacticum (PXE) DESIGN: Monocenter cross sectional prospective case series.
American journal of ophthalmology.Am J Ophthalmol.2014 Apr 10. pii: S0002-9394(14)00192-5. doi: 10.1016/j.ajo.2014.04.005. [Epub ahead of print]
PURPOSE: To investigate the impact of Bruch Membrane pathology on the choroid in Pseudoxanthoma elacticum (PXE) DESIGN: Monocenter cross sectional prospective case series.METHODS: The study included 61 eyes of 51 patients with PXE and 54 eyes of 54 normal subjects. The diagnosis of PXE was based on
PMID 24727260

Generalized choriocapillaris dystrophy, a distinct phenotype in the spectrum of ABCA4-associated retinopathies.

Bertelsen M1, Zernant J, Larsen M, Duno M, Allikmets R, Rosenberg T.Author information 1Kennedy Center Eye Clinic, Kennedy Center, Gl. Landevej 7, Glostrup, 2600, Denmark.AbstractPurpose: To describe a particular form of autosomal recessive generalized choriocapillaris dystrophy phenotype associated with ABCA4 mutations. Methods: A cohort of 30 patients with identified ABCA4 mutations and a distinct phenotype was studied. A retrospective review of history, fundus photographs, electroretinography, visual field testing, dark adaptometry and optical coherence tomography was performed. Genetic analyses were performed by ABCA4 microarray analysis, high resolution melting and/or next generation sequencing of all protein-coding sequences of the ABCA4 gene. Results: The earliest recorded manifestation of ABCA4-associated disease was a central bull's eye type of macular dystrophy that progressed to chorioretinal atrophy of the macula with coarse rounded hyperpigmentations and expanding involvement of the periphery. The mean age at first presentation was 10.3 years, the longest follow-up was 61 years. All patients had two ABCA4 mutations identified, confirming the molecular genetic diagnosis of an ABCA4-associated disease. Most patients harbored at least one mutation classified as 'severe', the most common of which was the p.N965S variant that had previously been found at a high frequency among patients with ABCA4-associated retinal dystrophies in Denmark. Conclusions: Generalized choriocapillaris dystrophy is a progressive ABCA4-associated phenotype characterized by early-onset macular dystrophy that disperses and expands to widespread end-stage chorioretinal atrophy with profound visual loss. All cases in this study were confirmed as harboring two ABCA4 mutations. Most of the ABCA4 mutations were classified as 'severe' explaining the early onset, panretinal degeneration, and fast progression of the disease.
Investigative ophthalmology & visual science.Invest Ophthalmol Vis Sci.2014 Apr 8. pii: iovs.13-13391v1. doi: 10.1167/iovs.13-13391. [Epub ahead of print]
Purpose: To describe a particular form of autosomal recessive generalized choriocapillaris dystrophy phenotype associated with ABCA4 mutations. Methods: A cohort of 30 patients with identified ABCA4 mutations and a distinct phenotype was studied. A retrospective review of history, fundus photographs
PMID 24713488

Japanese Journal

Clinical and Serial MRI Findings of a Sialidosis Type I Patient with a Novel Missense Mutation in the NEU1 Gene

Sekijima Yoshiki,Nakamura Katsuya,Kishida Dai,Narita Aya,Adachi Kaori,Ohno Kosaku,Nanba Eiji,Ikeda Shu-ichi
Internal Medicine 52(1), 119-124, 2013
… On admission, subnormal intelligence, dysarthria, myoclonus, intentional tremors, limb and gait ataxia, hyperreflexia and macular cherry-red spots were observed. … Serial brain MRI showed diffuse brain atrophy progressing rapidly over the 41-month observation period. …
NAID 130003365573

脈絡膜新生血管抜去術後に長期視力良好であった加齢黄斑変性の1例

屋宜友子,山本香織,堀貞夫,YAGI Tomoko,YAMAMOTO Kaori,HORI Sadao
東京女子医科大学雑誌 82(E1), E206-E210, 2012-01-31
… 背景:加齢黄斑変性(age-related macular degeneration :AMD)における脈絡膜新生血管(choroidal neovascularization:CNV)に対して、CNV抜去術を施行し、8年にわたって良好な視力を維持している症例を経験した。 …
NAID 110008767977

Dry age-related macular degeneration: A currently unmet clinical need

Girmens Jean-François,Sahel José-Alain,Marazova Katia
Intractable & Rare Diseases Research 1(3), 103-114, 2012
… Age-related macular degeneration (AMD) is a leading cause of severe visual impairment and disability in older people worldwide. … Although considerable advances in the management of the neovascular form of AMD have been made in the last decade, no therapy is yet available for the advanced dry form of AMD (geographic atrophy). …
NAID 130003397539