| Macroglossia |
| Classification and external resources |
| Specialty |
medical genetics |
| ICD-10 |
Q38.2 |
| ICD-9-CM |
529.8, 750.15 |
| OMIM |
153630 |
| DiseasesDB |
7689 |
| MedlinePlus |
002250 |
| eMedicine |
ent/746 |
| MeSH |
D008260 |
Macroglossia is the medical term for an unusually large tongue. Severe enlargement of the tongue can cause cosmetic and functional difficulties including in speaking, eating, swallowing and sleeping. Macroglossia is uncommon, and usually occurs in children. There are many causes. Treatment is dependent upon the exact cause.
Contents
- 1 Classification
- 2 Signs and symptoms
- 3 Causes
- 4 Diagnosis
- 5 Treatment and prognosis
- 6 Epidemiology
- 7 References
- 8 External links
Classification
The ICD-10 lists macroglossia under "other congenital malformations of the digestive system". Definitions of macroglossia have been proposed, including "a tongue that protrudes beyond the teeth during [the] resting posture" and "if there is an impression of a tooth on the lingual border when the patients slightly open their mouths".[1] Others have suggested there is no objective definition of what constitutes macroglossia.[2] Some propose a distinction between true macroglossia, when histologic abnormalities correlate with the clinical findings of tongue enlargement, and relative macroglossia, where histology does not provide a pathologic explanation for the enlargement. Common examples of true macroglossia are vascular malformations, muscular enlargement and tumors; whilst Down syndrome is an example of relative macroglossia.[2] Pseudomacryglossia refers to a tongue that is of normal size but gives a false impression of being too large in relation to adjacent anatomical structures.[3] The Myer classification subdivides macroglossia into generalized or localized.[1]
Signs and symptoms
Although it may be asymptomatic, symptoms usually are more likely to be present and more severe with larger tongue enlargements. Signs and symptoms include:
- Dyspnea - difficult, noisy breathing, obstructive sleep apnea[4] or airway obstruction[5]
- Dysphagia - difficulty swallowing and eating[5]
- Dysphonia - disrupted speech, possibly manifest as lisping[5]
- Sialorrhea - drooling[5]
- Angular cheilitis - sores at the corners of the mouth
- Crenated tongue - indentations on the lateral borders of the tongue caused by pressure from teeth ("pie crust tongue")[5]
- Open bite - a type of malocclusion of the teeth[5]
- Mandibular prognathism - enlarged mandible[5]
- Mouth breathing
- Orthodontic abnornamlities - including diastema and tooth spacing[3]
A tongue that constantly protrudes from the mouth is vulnerable to drying out, ulceration, infection or even necrosis.[5]
Causes
Macroglossia may be caused by a wide variety of congenital and acquired conditions. Isolated macroglossia has no determinable cause.[1] The most common causes of tongue enlargement are vascular malformations (e.g. lymphangioma or hemangioma) and muscular hypertrophy (e.g. Beckwith-Weidemann syndrome or hemihyperplasia).[5] Enlargement due to lymphangioma gives the tongue a pebbly appearance with multiple superficial dilated lymphatic channels. Enlargement due to hemihyperplasia is unilateral. In edentulous persons, a lack of teeth leaves more room for the tongue to expand into laterally, which can create problems with wearing dentures and may cause pseudomacroglossia.
Amyloidosis is an accumulation of insoluble proteins in tissues that impedes normal function.[6] This can be a cause of macroglossia if amyloid is deposited in the tissues of the tongue, which gives it a nodular appearance. Beckwith-Wiedemann syndrome is a rare hereditary condition, which may include other defects such as omphalocele, visceromegaly, gigantism or neonatal hypoglycemia.[7] The tongue may show a diffuse, smooth generalized enlargement.[5] The face may show maxillary hypoplasia causing relative mandibular prognathism. Apparent macroglossia can also occur in Down syndrome.[8] The tongue has a papillary, fissured surface.[5] Macroglossia may be a sign of hypothyroid disorders.
Other causes include mucopolysaccharidosis,[9] neurofibromatosis,[5] multiple endocrine neoplasia type 2B,[5] myxedema,[5] acromegaly,[5] angioedema,[5] tumors (e.g. carcinoma),[5] Glycogen storage disease type 2,[10] Simpson-Golabi-Behmel syndrome,[1][11] Triploid Syndrome,[medical citation needed] trisomy 4p,[medical citation needed] fucosidosis,[medical citation needed] alpha-mannosidosis,[12] Klippel-Trenaunay-Weber syndrome,[1] cardiofaciocutaneous syndrome,[1] Ras pathway disorders,[1] transient neonatal diabetes,[1] and lingual thyroid.[13]
Diagnosis
Macroglossia is usually diagnosed clinically.[3] Sleep endoscopy and imaging may be used for assessment of obstructive sleep apnea.[4] The initial evaluation of all patients with macroglossia may involve abdominal ultrasound and molecular studies for Beckwith-Wiedemann syndrome.[1]
Treatment and prognosis
Treatment and prognosis of macroglossia depends upon its cause, and also upon the severity of the enlargement and symptoms it is causing. No treatment may be required for mild cases or cases with minimal symptoms. Speech therapy may be beneficial, or surgery to reduce the size of the tongue (reduction glossectomy). Treatment may also involve correction of orthodontic abnormalities that may have been caused by the enlarged tongue.[3] Treatment of any underlying systemic disease may be required, e.g. radiotherapy.[3]
Epidemiology
Macroglossia is uncommon, and usually occurs in children.[5] Macroglossia has been reported to have a positive family history in 6% of cases. The National Organization of Rare Disorders lists macroglossia as a rare disease (less than 200 000 individuals in the US).[1]
References
- ^ a b c d e f g h i j Prada, CE; Zarate, YA; Hopkin, RJ (February 2012). "Genetic causes of macroglossia: diagnostic approach.". Pediatrics 129 (2): e431–7. doi:10.1542/peds.2011-1732. PMID 22250026.
- ^ a b Vogel, JE; Mulliken, JB; Kaban, LB (December 1986). "Macroglossia: a review of the condition and a new classification.". Plastic and reconstructive surgery 78 (6): 715–23. doi:10.1097/00006534-198678060-00001. PMID 2947254.
- ^ a b c d e Topouzelis, N; Iliopoulos, C; Kolokitha, OE (April 2011). "Macroglossia.". International dental journal 61 (2): 63–9. doi:10.1111/j.1875-595x.2011.00015.x. PMID 21554274.
- ^ a b Perkins, JA (December 2009). "Overview of macroglossia and its treatment.". Current Opinion in Otolaryngology & Head and Neck Surgery 17 (6): 460–5. doi:10.1097/moo.0b013e3283317f89. PMID 19713845.
- ^ a b c d e f g h i j k l m n o p q r Bouquot, Brad W. Neville , Douglas D. Damm, Carl M. Allen, Jerry E. (2002). Oral & maxillofacial pathology (2. ed.). Philadelphia: W.B. Saunders. pp. 9–10. ISBN 0721690033.
- ^ Merck Manual 17th Ed.
- ^ Dios, Pedro Diz; Posse, Jacobo Limeres; Sanromán, Jacinto Fernández; García, Emma Vázquez (September 2000). "Treatment of macroglossia in a child with Beckwith-Wiedemann syndrome.". Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 58 (9): 1058–61. doi:10.1053/joms.2000.8753. PMID 10981990.
- ^ Guimaraes CV, Donnelly LF, Shott SR, Amin RS, Kalra M (October 2008). "Relative rather than absolute macroglossia in patients with Down syndrome: implications for treatment of obstructive sleep apnea". Pediatr Radiol 38 (10): 1062–7. doi:10.1007/s00247-008-0941-7. PMID 18685841.
- ^ http://ghr.nlm.nih.gov/condition=mucopolysaccharidosistypei
- ^ http://moon.ouhsc.edu/kfung/jty1/neurohelp/ZNN0IE23.htm
- ^ http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=312870
- ^ http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=248500
- ^ Cawson, R. A.; Odell, E. W. (2002). Cawson's essentials of oral pathology and oral medicine (7th ed.). Edinburgh: Churchill Livingstone. p. 219. ISBN 0443071055.
External links
- UK NHS National Amyloidosis Centre Patient Information Site
- Grand Rounds Site
|
Congenital malformations and deformations of digestive system (Q35–Q45, 749–751)
|
|
| Upper GI tract |
| Tongue, mouth and pharynx |
- Cleft lip and palate
- Van der Woude syndrome
- tongue
- Ankyloglossia
- Macroglossia
- Hypoglossia
|
|
| Esophagus |
- EA/TEF
- Esophageal atresia: types A, B, C, and D
- Tracheoesophageal fistula: types B, C, D and E
- esophageal rings
- Esophageal web (upper)
- Schatzki ring (lower)
|
|
| Stomach |
- Pyloric stenosis
- Hiatus hernia
|
|
|
| Lower GI tract |
| Intestines |
- Intestinal atresia
- Meckel's diverticulum
- Hirschsprung's disease
- Intestinal malrotation
- Dolichocolon
- Enteric duplication cyst
|
|
| Rectum/anal canal |
- Imperforate anus
- Rectovestibular fistula
- Persistent cloaca
- Rectal atresia
|
|
|
| Accessory |
| Pancreas |
- Annular pancreas
- Accessory pancreas
- Johanson–Blizzard syndrome
- Pancreas divisum
|
|
| Bile duct |
- Choledochal cysts
- Biliary atresia
|
|
| Liver |
- Alagille syndrome
- Polycystic liver disease
|
|
|
|
Index of the mouth
|
|
| Description |
|
|
| Disease |
- Congenital
- face and neck
- cleft
- digestive system
- Neoplasms and cancer
- Other
- Symptoms and signs
|
|
| Treatment |
|
|
Index of digestion
|
|
| Description |
- Anatomy
- Physiology
- Development
|
|
| Disease |
- Congenital
- Neoplasms and cancer
- Inflammatory bowel disease
- Gluten sensitivity
- Other
- Symptoms and signs
- Blood tests
|
|
| Treatment |
- Procedures
- Drugs
- anabolic steroids
- antacids
- diarrhoea and infection
- bile and liver
- functional gastrointestinal disorders
- laxatives
- peptic ulcer and reflux
- nausea and vomiting
- other
- Surgery
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