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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/08 21:03:55」(JST)

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1. 脳卒中スケールおよび重症度分類システムの利用および有用性 use and utility of stroke scales and grading systems
2. 先天性代謝異常：個々の障害の発見 inborn errors of metabolism identifying the specific disorder
3. Stroke prognosis in adults
4. 特発性脳出血：予後および治療 spontaneous intracerebral hemorrhage prognosis and treatment
5. 特発性脳動脈および頚動脈の解離：治療および予後 spontaneous cerebral and cervical artery dissection treatment and prognosis

English Journal

Development of an alternative culture medium for the selective enumeration of Lactobacillus casei in fermented milk.

Colombo M1, Oliveira AE1, Carvalho AF2, Nero LA3.Author information 1Departamento de Veterinária, Universidade Federal de Viçosa, Campus UFV, 36570 000 Viçosa, MG, Brazil.2Departamento de Tecnologia de Alimentos, Universidade Federal de Viçosa, Campus UFV, 36570 000 Viçosa, MG, Brazil.3Departamento de Veterinária, Universidade Federal de Viçosa, Campus UFV, 36570 000 Viçosa, MG, Brazil. Electronic address: nero@ufv.br.AbstractMonitoring the populations of probiotic strains of the species Lactobacillus casei in food is required by food industries in order to assure that a minimum concentration of these organisms will be ingested by consumers. In this context, Petrifilm™ AC plates can be used along with selective culture media to allow the enumeration of specific groups of lactic acid bacteria. The present study aimed to assess chemical substances as selective agents for Lb. casei in order to propose a selective culture medium to be used with Petrifilm™ AC plates as an alternative protocol for the enumeration of probiotic strains of this species in fermented milk. Twenty-six probiotic and starter cultures (including six strains of Lb. casei) were plated on de Man Rogosa and Sharpe (MRS) agar with distinct concentrations of nalidixic acid, bile, lithium chloride, metronidazole, sodium propionate, and vancomycin. Vancomycin at 10 mg/L demonstrated selective activity for Lb. casei. In addition, 2,3,5-triphenyltetrazolium chlorine was identified as a compound that did not inhibit Lb. casei, and Petrifilm™ AC plates used with MRS and vancomycin at 10 mg/L (MRS-V) demonstrated more colonies of this organism when incubated under anaerobic conditions than aerobic conditions. Acidophilus milk and yoghurt were prepared, added to Lb. casei strains, and stored at 4 °C. Lb. casei populations were monitored using MRS-V and MRTLV by conventional plating and associated with Petrifilm™ AC plates. All correlation indices between counts obtained by conventional plating and Petrifilm™ AC were significant (p < 0.05), but the best performance was observed for growth on MRS-V. The obtained data indicate the efficiency of using MRS-V associated with Petrifilm™ AC plates for the enumeration of Lb. casei strains in fermented milk. However, the selective potential of this culture medium must be evaluated considering the specific strains of Lb. casei and the starter cultures inoculated in the fermented milk that requires monitoring.
Food microbiology.Food Microbiol.2014 May;39:89-95. doi: 10.1016/j.fm.2013.11.008. Epub 2013 Nov 21.
Monitoring the populations of probiotic strains of the species Lactobacillus casei in food is required by food industries in order to assure that a minimum concentration of these organisms will be ingested by consumers. In this context, Petrifilm™ AC plates can be used along with selective culture
PMID 24387857

A field effect transistor biosensor with a γ-pyrone derivative engineered lipid-sensing layer for ultrasensitive Fe(3+) ion detection with low pH interference.

Nguyen TD1, Labed A2, El Zein R3, Lavandier S4, Bedu F5, Ozerov I6, Dallaporta H7, Raimundo JM8, Charrier AM9.Author information 1Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France; School of Engineering Physics, Hanoi University of Science and Technology, Hanoi, Viet Nam. Electronic address: tuyenkstnk46@gmail.com.2Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France. Electronic address: labed.abdel@gmail.com.3Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France.4Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France. Electronic address: lavandier@cinam.univ-mrs.fr.5Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France. Electronic address: bedu@cinam.univ-mrs.fr.6Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France. Electronic address: ozerov@cinam.univ-mrs.fr.7Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France. Electronic address: dallaporta@cinam.univ-mrs.fr.8Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France. Electronic address: raimundo@cinam.univ-mrs.fr.9Aix-Marseille Université, CNRS, CINaM UMR 7325, 13288 Marseille, France. Electronic address: charrier@cinam.univ-mrs.fr.AbstractField effect transistors have risen as one of the most promising techniques in the development of biomedical diagnosis and monitoring. In such devices, the sensitivity and specificity of the sensor rely on the properties of the active sensing layer (gate dielectric and probe layer). We propose here a new type of transistor developed for the detection of Fe(3+) ions in which this sensing layer is made of a monolayer of lipids, engineered in such a way that it is not sensitive to pH in the acidic range, therefore making the device perfectly suitable for biomedical diagnosis. Probes are γ-pyrone derivatives that have been grafted to the lipid headgroups. Affinity constants derived for the chelator/Fe(3+) complexation as well as for other ions demonstrate very high sensitivity and specificity towards ferric ions with values as high as 5.10(10)M and a detected concentration as low as 50fM.
Biosensors & bioelectronics.Biosens Bioelectron.2014 Apr 15;54:571-7. doi: 10.1016/j.bios.2013.11.051. Epub 2013 Nov 25.
Field effect transistors have risen as one of the most promising techniques in the development of biomedical diagnosis and monitoring. In such devices, the sensitivity and specificity of the sensor rely on the properties of the active sensing layer (gate dielectric and probe layer). We propose here
PMID 24333568

In vivo evidence of an age-related increase in ATP cost of contraction in the plantar flexor muscles.

Layec G, Trinity JD, Hart CR, Kim SE1, Groot HJ, Le Fur Y2, Sorensen JR, Jeong EK1, Richardson RS.Author information 1§Department of Radiology and Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, U.S.A.2¶Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 7339, Faculté de Médecine de Marseille, Marseille, France.AbstractImpaired skeletal muscle efficiency potentially contributes to the age-related decline in exercise capacity and may explain the altered haemodynamic response to exercise in the elderly. Thus we examined whether (i) the ATP cost of contraction increases with age, and (ii) this results in altered convective O2 delivery to maintain microvascular oxygenation in the calf muscle. To this aim, we used an integrative experimental approach combining 31P-MRS (magnetic resonance spectroscopy), Doppler ultrasound imaging and NIRS (near-IR spectroscopy) during dynamic plantar flexion exercise at 40% of WRmax (maximal power output) in 20 healthy young and 20 older subjects matched for physical activity. The ATP cost of contraction was significantly higher in the old (7.2±4.1 mM/min per W) compared with the young (2.4±1.9 mM/min per W; P<0.05) and this was only significantly correlated with the plantar flexion WRmax value in the old subjects (r=-0.52; P<0.05). Even when differences in power output were taken into account, end-exercise blood flow (old, 259±168 ml/min per W and young, 134±40 ml/min per W; P<0.05) and convective O2 delivery (old, 0.048±0.031 l/min per W and young, 0.026±0.008 l/min per W; P<0.05) were greater in the old in comparison with the young subjects. In contrast, the NIRS oxyhaemoglobin, deoxyhaemoglobin and microvascular oxygenation indices were not significantly different between the groups (P>0.05). Therefore the present study reveals that, although the peripheral haemodynamic responses to plantar flexion exercise appear to be appropriate, the elevated energy cost of contraction and associated reduction in the WRmax value in this muscle group may play a role in limiting exercise capacity with age.
Clinical science (London, England : 1979).Clin Sci (Lond).2014 Apr 1;126(8):581-92. doi: 10.1042/CS20130442.
Impaired skeletal muscle efficiency potentially contributes to the age-related decline in exercise capacity and may explain the altered haemodynamic response to exercise in the elderly. Thus we examined whether (i) the ATP cost of contraction increases with age, and (ii) this results in altered conv
PMID 24224517

Japanese Journal

医薬品開発におけるMRIの応用 (特集薬理学領域における磁気共鳴画像法の可能性)

石川誠
日本薬理学雑誌 : くすりとからだ : ファーマコロジカ 140(4), 161-165, 2012-10
NAID 40019448697

Site-specific deletions in the tomato genome by the CinH-RS2 and ParA-MRS recombination systems

Zhou Yin,Yau Yuan-Yeu,Ow David W. [他]
Plant biotechnology reports 6(3), 225-232, 2012-07
NAID 40019353629

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