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a cytokine secreted by helper T cells in response to stimulation by antigens and that acts on other cells of the immune system (as by activating macrophages)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/04/16 07:06:04」(JST)

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Lymphokines are a subset of cytokines that are produced by a type of immune cell known as a lymphocyte.^[1] They are protein mediators typically produced by T cells to direct the immune system response by signaling between its cells. Lymphokines have many roles, including the attraction of other immune cells, including macrophages and other lymphocytes, to an infected site and their subsequent activation to prepare them to mount an immune response. Circulating lymphocytes can detect a very small concentration of lymphokine and then move up the concentration gradient towards where the immune response is required. Lymphokines aid B cells to produce antibodies.

Important lymphokines secreted by the T helper cell include:^[2]

Interleukin 2
Interleukin 3
Interleukin 4
Interleukin 5
Interleukin 6
Granulocyte-macrophage colony-stimulating factor
Interferon-gamma

References

^ Julius M. Cruse; Robert Edwin Lewis (20 April 2009). Illustrated dictionary of immunology. CRC Press. pp. 208–. ISBN 978-0-8493-7987-1. Retrieved 24 April 2011.
^ Guyton, AC; Hall, JE. (2006) Medical Physiology, Elsevier Saunders. 11th edition, pp.447.

External links

Lymphokines at the US National Library of Medicine Medical Subject Headings (MeSH)

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English Journal

Comparative study of bone marrow and blood plasma levels of IL-2 in aplastic anaemia and their relationship with disease severity.

De R, Dutta A, Dolai TK, Ghosh K, Halder A.
Hematology (Amsterdam, Netherlands). 2019 Dec;24(1)84-88.
Interleukin-2 (alias: IL-2, TCGF, Lymphokine), a type of interleukin, is also a potent signalling molecule in the signalling cascade of the immune-mediated activation of T Lymphocytes leading to the destruction of haematopoietic stem cell (HSC) which is the basis of acquired aplastic anaemia (AAA).
PMID 30139310

Yellow fever virus modulates cytokine mRNA expression and induces activation of caspase 3/7 in the human hepatocarcinoma cell line HepG2.

Holanda GM, Casseb SMM, Quaresma JAS, Vasconcelos PFC, Cruz ACR.
Archives of virology. 2019 Apr;164(4)1187-1192.
Yellow fever virus (YFV) penetrates the skin through the bite of a vector mosquito and spreads to various organs, mainly the liver, where it causes lesions and induces necrosis and apoptosis. We evaluated the mRNA expression of various cytokines and the activation of caspases in HepG2 cells infected
PMID 30725182

Molecular cloning of IL-6, IL-10, IL-11, IFN-ɤ and modulation of pro- and anti-inflammatory cytokines in cobia (Rachycentron canadum) after Photobacterium damselae subsp. piscicida infection.

Tran HB, Chen SC, Chaung HC, Cheng TC.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 2019 Apr;230()10-18.
Photobacterium damselae subsp. piscicida (P. damselae subsp. piscicida) is the agent of Photobacteriosis, a serious fish disease that produces an acute infection and high mortality in farmed cobia. It has been proved that regulation of pro- and anti-inflammatory cytokines play a central role in init
PMID 30665028

Japanese Journal

Stimulation of neuronal cells by culture supernatant of T lymphocytes triggered by anti-CD3 mAb followed by propagation in the presence of interleukin-2

Microbiology and immunology 60(1), 47-55, 2016-01
NAID 40020725461

Influence of transfusion of lymphokine-activated T killer cells on inflammatory responses in dogs after laparotomy

Journal of Veterinary Medical Science advpub(0), 579-585, 2016
NAID 130005115351

免疫細胞療法 (特集大腸癌の最新治療 : 治癒に向けた最先端研究)

日本臨床 72(1), 42-48, 2014-01
NAID 40019920508

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