WordNet

of or relating to interstices
respiratory disease characterized by inflammation of the lung parenchyma (excluding the bronchi) with congestion caused by viruses or bacteria or irritants
of or relating to lymphocytes; "lymphocytic leukemia"

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肺炎

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/12/18 05:44:48」(JST)

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Lymphocytic interstitial pneumonia (also called lymphocytic interstitial pneumonitis or LIP) is a syndrome secondary to autoimmune and other lymphoproliferative disorders. Symptoms include fever, cough, and shortness of breath. Lymphocytic interstitial pneumonia applies to disorders associated with both monoclonal or polyclonal gammopathy.^[1]

Symptoms

In patients with lymphocytic interstitial pneumonia, these patients may present with lymphadenopathy, enlarged liver, enlarged spleen, enlarged salivary gland, thickening and widening of the extremities of the fingers and toes (clubbing), and breathing symptoms such as shortness of breath and wheezing.

Diagnosis

Arterial blood gases may reveal hypoxemia when tested in a lab. Respiratory alkalosis may also be present.^[2] Peripheral lymphocytosis can be observed.^[3] A lung biopsy may also be indicated.^[4]

Causes

Possible causes of lymphocytic interstitial pneumonia include the Epstein-Barr virus and Human Immunodeficiency Virus.

Treatment

Patients presenting with no symptoms, and not affected by the syndrome may not require treatment. Corticosteroids have been reported to be of benefit in select patients. Bronchodilators may assist with breathing issues and resolution may occur with the use of Highly Active Anti-Retroviral Therapy. However, responses to different treatments are widely varied, and no single first line treatment represents the default treatment for lymphocytic interstitial pneumonia.^[5]

References

^ The Pathology of Idiopathic Interstitial Pneumonias Carol Farver, MD
^ Teirstein AS, Rosen MJ. Lymphocytic interstitial pneumonia. Clin Chest Med 1988;9:467-471
^ Pitt J. Lymphocytic interstitial pneumonia. Pediatr Clin N Am 1991;38:89-95.
^ Strimlan CV, Rosenow EC, Weiland LH, Brown LR. Lymphocytic interstitial pneumonia. Review of 13 cases. Ann Intern Med 1978;88:616-621
^ Teirstein AS, Rosen MJ. Lymphocytic interstitial pneumonia. Clin Chest Med 1988;9:467-471

UpToDate Contents

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1. 成人におけるリンパ球性間質性肺炎 lymphoid interstitial pneumonia in adults
2. 小児におけるリンパ性間質性肺炎 lymphocytic interstitial pneumonia in children
3. シェーグレン症候群関連間質性肺疾患：臨床症状、評価、および診断 interstitial lung disease associated with sjogrens syndrome clinical manifestations evaluation and diagnosis
4. シェーグレン症候群関連間質性肺疾患：管理と予後 interstitial lung disease associated with sjogrens syndrome management and prognosis
5. Diagnostic approach to the adult with cystic lung disease

English Journal

Pet groomer's lung: A novel occupation related hypersensitivity pneumonitis related to pyrethrin exposure in a pet groomer.

Pu CY1, Rasheed MR2, Sekosan M1, Sharma V3.
American journal of industrial medicine.Am J Ind Med.2016 Oct 17. doi: 10.1002/ajim.22664. [Epub ahead of print]
A 61-year-old man was evaluated for a 2 month history of cough and dyspnea without relevant exposures other than pyrethrin containing insecticidal sprays he used while grooming dogs almost daily. High Resolution Computed Tomography (HRCT) of the chest demonstrated a Non-Specific Interstitial Pneumon
PMID 27747913

Bronchiectasis and other chronic lung diseases in adolescents living with HIV.

Attia EF1, Miller RF, Ferrand RA.
Current opinion in infectious diseases.Curr Opin Infect Dis.2016 Oct 7. [Epub ahead of print]
PURPOSE OF REVIEW: The incidence of pulmonary infections has declined dramatically with improved access to antiretroviral therapy (ART) and cotrimoxazole prophylaxis, but chronic lung disease (CLD) is an increasingly recognized but poorly understood complication in adolescents with perinatally acqui
PMID 27753690

Cathepsin L Helps to Defend Mice from Infection with Influenza A.

Xu X1, Greenland JR1,2, Gotts JE1,3, Matthay MA1,3, Caughey GH1,2,3.
PloS one.PLoS One.2016 Oct 7;11(10):e0164501. doi: 10.1371/journal.pone.0164501. eCollection 2016.
Host-derived proteases can augment or help to clear infections. This dichotomy is exemplified by cathepsin L (CTSL), which helps Hendra virus and SARS coronavirus to invade cells, but is essential for survival in mice with mycoplasma pneumonia. The present study tested the hypothesis that CTSL prote
PMID 27716790