類脂質、リ・イド

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/03 12:46:35」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 先天性副腎過形成の稀な原因 uncommon causes of congenital adrenal hyperplasia
2. 成人における嚥下性肺炎 aspiration pneumonia in adults
3. 間質性肺疾患の診断における気管支肺胞洗浄検査の役割 role of bronchoalveolar lavage in diagnosis of interstitial lung disease
4. 妊娠時のアンドロゲン過剰症の原因 causes of gestational hyperandrogenism
5. 炭化水素中毒 hydrocarbon poisoning

English Journal

Improving cabazitaxel chemical stability in parenteral lipid emulsions using cholesterol.

Shao Y1, Zhang C1, Yao Q1, Wang Y1, Tian B1, Tang X1, Wang Y2.Author information 1School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.2School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China. Electronic address: tangpharma@gmail.com.AbstractIntravenous lipid emulsions of cabazitaxel (CLEs) with a high stability were prepared by adding cholesterol (CH) to provide a new and more suitable delivery system for its administration. The factors affecting CLEs, such as the solubility of cabazitaxel in various oils, different kinds of lecithin, pH, different types of oil phases, and different concentrations of lipoid E80®, CH and poloxamer 188 were investigated systematically. The degradation of cabazitaxel in aqueous solution and lipid emulsion both followed pseudo first-order kinetics. A degradation mechanism was suggested by the U-shaped pH-rate profile of cabazitaxel. A formulation containing 0.5% (w/v) CH and another formulation without CH were made to investigate the protective influence of CH on the chemical stability of CLEs. The activation energy of the two formulations was calculated to be 65.74±6.88 and 54.24±1.43kJ/mol (n=3), respectively. Compared with the untreated CH, the shelf-life of cabazitaxel with added CH was longer, namely 134.0±23.4days versus 831.4±204.4days (n=3) at 4°C. This indicates that the addition of CH significantly improved the lifetime of cabazitaxel in intravenous lipid emulsions. The hydrogen bonding that takes place between cabazitaxel and CH accounts for the protective effect of CH on the chemical stability of CLEs in two ways: preventing cabazitaxel from leaking and hydrolyzing in aqueous solution and hindering hydrolysis in the oil phase. Finally, the hypothesis was confirmed by LC/TOFMS and Fourier-transform infrared-spectroscopy. As a result, CLEs were obtained successfully by the addition of CH and were stable enough to allow further research.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2014 Feb 14;52:1-11. doi: 10.1016/j.ejps.2013.09.024. Epub 2013 Oct 20.
Intravenous lipid emulsions of cabazitaxel (CLEs) with a high stability were prepared by adding cholesterol (CH) to provide a new and more suitable delivery system for its administration. The factors affecting CLEs, such as the solubility of cabazitaxel in various oils, different kinds of lecithin,
PMID 24153395

STAR splicing mutations cause the severe phenotype of lipoid congenital adrenal hyperplasia: insights from a novel splice mutation and review of reported cases.

Camats N, Pandey AV, Fernández-Cancio M, Fernández JM, Ortega AM, Udhane S, Andaluz P, Audí L, Flück CE.Author information Pediatric Endocrinology, Department of Pediatrics and Department of Clinical Research, University Children's Hospital Bern, Bern, Switzerland.AbstractOBJECTIVE: The steroidogenic acute regulatory protein (StAR) transports cholesterol to the mitochondria for steroidogenesis. Loss of StAR function causes lipoid congenital adrenal hyperplasia (LCAH) which is characterized by impaired synthesis of adrenal and gonadal steroids causing adrenal insufficiency, 46,XY disorder of sex development (DSD) and failure of pubertal development. Partial loss of StAR activity may cause adrenal insufficiency only.
Clinical endocrinology.Clin Endocrinol (Oxf).2014 Feb;80(2):191-199. doi: 10.1111/cen.12293. Epub 2013 Aug 17.
OBJECTIVE: The steroidogenic acute regulatory protein (StAR) transports cholesterol to the mitochondria for steroidogenesis. Loss of StAR function causes lipoid congenital adrenal hyperplasia (LCAH) which is characterized by impaired synthesis of adrenal and gonadal steroids causing adrenal insuffic
PMID 23859637

Binary lipids-based nanostructured lipid carriers for improved oral bioavailability of silymarin.

Shangguan M, Lu Y, Qi J, Han J, Tian Z, Xie Y, Hu F, Yuan H, Wu W.Author information 1Key Laboratory of Smart Drug Delivery of Ministry of Education and PLA, School of Pharmacy, Fudan University, Shanghai, PR China.AbstractThe main purpose of this study was to prepare binary lipids-based nanostructured lipid carriers to improve the oral bioavailability of silymarin, a poorly water-soluble liver protectant. Silymarin-loaded nanostructured lipid carriers were prepared by the method of high-pressure homogenization with glycerol distearates (Precirol ATO-5) and oleic acid as the solid and liquid lipids, respectively, and lecithin (Lipoid E 100) and Tween-80 as the emulsifiers. The silymarin-nanostructured lipid carrier prepared under optimum conditions was spherical in shape with mean particle size of ∼78.87 nm, entrapment efficiency of 87.55%, loading capacity of 8.32%, and zeta potential of -65.3 mV, respectively. In vitro release of silymarin-nanostructured lipid carriers was very limited even after 12 h, while in vitro lipolysis showed fast digestion of nanostructured lipid carriers within 1 h. Relative oral bioavailability of silymarin-nanostructured lipid carriers in Beagle dogs was 2.54- and 3.10-fold that of marketed Legalon® and silymarin solid dispersion pellets, respectively. It was concluded that nanostructured lipid carriers were potential drug delivery systems to improve the bioavailability of silymarin. Other than improved dissolution, alternative mechanisms such as facilitated absorption as well as lymphatic transport may contribute to bioavailability enhancement.
Journal of biomaterials applications.J Biomater Appl.2014 Feb;28(6):887-96. doi: 10.1177/0885328213485141. Epub 2013 Sep 5.
The main purpose of this study was to prepare binary lipids-based nanostructured lipid carriers to improve the oral bioavailability of silymarin, a poorly water-soluble liver protectant. Silymarin-loaded nanostructured lipid carriers were prepared by the method of high-pressure homogenization with g
PMID 24008629

Japanese Journal

ネズミ忌避剤 (ハッカ油) の吸入による外因性リポイド肺炎の1例

村瀬享子,野田一成,大滝美浩 [他],安田順一,青木茂行,清水誠一郎
日本呼吸器学会誌 = Annals of the Japanese Respiratory Society 2(4), 466-470, 2013-07-10
NAID 10031183769

植物性脂肪による外因性リポイド肺炎にMycobacterium fortuitum感染を合併した1例

友松克允,小熊剛,滝口寛人,友松裕美,新美京子,端山直樹,青木琢也,浦野哲哉,浅野浩一郎,阿部直
気管支学 : 日本気管支研究会雑誌 35(2), 156-161, 2013-03-25
背景.外因性リポイド肺炎は,誤嚥・吸入した油脂により発症する比較的稀な疾患である.今回,我々は植物性脂肪からなる栄養食品の摂取により発症し, Mycobacterium fortuitum感染を合併した外因性リポイド肺炎を経験したので報告する.症例. 82歳女性.右上顎洞癌に対する放射線治療後に7カ月間持続する乾性咳嗽が出現し,胸部X線, CTで右中下肺野に浸潤影が認められた.気管支肺胞洗浄(BA …
NAID 110009597487

Optical coherence tomography visualization of posterior vitreous membrane adhesion in uncomplicated solitary retinal astrocytic hamartoma

Makino Shinji,Tampo Hironobu
自治医科大学紀要 = Jichi Medical University Journal 36, 91-94, 2013-03
… However, in rare instances, symptomatic alterations, suchas tumor enlargement with leakage, macular edema, accumulation of lipoid exudates, serous retinaldetachment, and vitreous hemorrhage, have been reported. …
NAID 120005437207

Related Pictures

★リンクテーブル★

リンク元	「類脂」「類脂質」「リポイド」
拡張検索	「lipoidosis」「lipoid nephrosis」「necrobiosis lipoidica diabeticorum」
関連記事	「lipo」