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the 5th letter of the Roman alphabet (同)e
the base of the natural system of logarithms; approximately equal to 2.718282...

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The effect of the leukotriene antagonist pranlukast on pediatric acute otitis media.

Nakamura Y1, Hamajima Y2, Suzuki M2, Esaki S2, Yokota M2, Oshika M2, Takagi I2, Yasui K2, Miyamoto N2, Sugiyama K2, Nakayama M2, Murakami S2.
International journal of pediatric otorhinolaryngology.Int J Pediatr Otorhinolaryngol.2016 Aug;87:34-8. doi: 10.1016/j.ijporl.2016.05.027. Epub 2016 May 20.
OBJECTIVE: Conventional treatment for acute otitis media mainly targets bacteria with antibiotics, neglecting to control for mediators of inflammation. Mediators of inflammation, such as leukotrienes, have been identified in patients with acute otitis media (AOM) or subsequent secretory otitis media
PMID 27368439

Montelukast as an add-on treatment in steroid dependant nephrotic syndrome, randomised-controlled trial.

Zedan MM1, El-Refaey A2, Zaghloul H3, Abdelrahim ME4, Osman A5, Zedan MM2, Eltantawy N4.
Journal of nephrology.J Nephrol.2016 Aug;29(4):585-92. doi: 10.1007/s40620-016-0297-2. Epub 2016 Mar 31.
BACKGROUND: The underlying mechanisms of nephrotic syndrome (NS) are still under debate and the need for more effective and less toxic treatment is challenging. We aimed to evaluate the efficacy of montelukast, a leukotriene receptor antagonist as an add-on therapy, and to explore the leukotriene (L
PMID 27032639

Structure and Ligand-Binding Mechanism of a Cysteinyl Leukotriene-Binding Protein from a Blood-Feeding Disease Vector.

Jablonka W1, Pham V1, Nardone G2, Gittis A2, Silva-Cardoso L3, Atella GC3, Ribeiro JM1, Andersen JF1.
ACS chemical biology.ACS Chem Biol.2016 Jul 15;11(7):1934-44. doi: 10.1021/acschembio.6b00032. Epub 2016 May 12.
Blood-feeding disease vectors mitigate the negative effects of hemostasis and inflammation through the binding of small-molecule agonists of these processes by salivary proteins. In this study, a lipocalin protein family member (LTBP1) from the saliva of Rhodnius prolixus, a vector of the pathogen T
PMID 27124118

Matsumoto Hisako,Hirata Yutaka,Otsuka Kojiro,Iwata Toshiyuki,Inazumi Aya,Niimi Akio,Ito Isao,Ogawa Emiko,Muro Shigeo,Sakai Hiroaki,Chin Kazuo,Oku Yoshitaka,Mishima Michiaki
Cytokine 57(1), 19-24, 2012-01
… The aim of this study was to assess effects of IL-13 on Ca[2+] oscillations in response to leukotriene D4 (LTD4) in human cultured ASMCs. … mRNA expressions of cysteinyl leukotriene 1 receptors (CysLT1R), CD38, involved with the ryanodine receptors (RyR) system, and transient receptor potential canonical (TRPC), involved with store-operated Ca[2+] entry (SOCE), were determined by real-time PCR. …
NAID 120003726117