WordNet
- the 1st letter of the Roman alphabet (同)a
- the blood group whose red cells carry the A antigen (同)type_A, group A
PrepTutorEJDIC
- answer / ampere
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/15 17:12:03」(JST)
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- 1. 喘息の治療において5-リポキシゲナーゼ経路に影響する薬剤 agents affecting the 5 lipoxygenase pathway in the treatment of asthma
- 2. 肥満細胞由来のメディエーター mast cell derived mediators
English Journal
- A sensitive fluorigenic substrate for selective in vitro and in vivo assay of leukotriene A4 hydrolase activity.
- Poras H, Duquesnoy S, Fournié-Zaluski MC, Ratinaud-Giraud C, Roques BP, Ouimet T.SourcePharmaleads, Paris BioPark, 75013 Paris, France.
- Analytical biochemistry.Anal Biochem.2013 Oct 15;441(2):152-61. doi: 10.1016/j.ab.2013.06.016. Epub 2013 Jul 11.
- Leukotriene A4 hydrolase (LTA4H) is a bifunctional zinc-dependent metalloprotease bearing both an epoxide hydrolase, producing the pro-inflammatory LTB4 leukotriene, and an aminopeptidase activity, whose physiological relevance has long been ignored. Distinct substrates are commonly used for each ac
- PMID 23851339
- Natural resolution of inflammation.
- Freire MO, Van Dyke TE.AbstractInflammation is a protective response essential for maintaining human health and for fighting disease. As an active innate immune reaction to challenge, inflammation gives rise to clinical cardinal signs: rubor, calor, dolor, tumor and functio laesa. Termination of acute inflammation was previously recognized as a passive process; a natural decay of pro-inflammatory signals. We now understand that the natural resolution of inflammation involves well-integrated, active, biochemical programs that return tissues to homeostasis. This review focuses on recent advances in the understanding of the role of endogenous lipid mediators that modulate cellular fate and inflammation. Biosynthesis of eicosanoids and other lipids in exudates coincides with changes in the types of inflammatory cells. Resolution of inflammation is initiated by an active class switch in lipid mediators, such as classic prostaglandins and leukotrienes, to the production of proresolution mediators. Endogenous pro-resolving lipid mediators, including arachidonic acid-derived lipoxins, aspirin-triggered lipoxins, ω3-eicosapentaenoic acid-derived resolvins of the E-series, docosahexaenoic acid-derived resolvins of the D-series, protectins and maresins, are biosynthesized during the resolution phase of acute inflammation. Depending on the type of injury and the type of tissue, the initial cells that respond are polymorphonuclear leukocytes, monocytes/macrophages, epithelial cells or endothelial cells. The selective interaction of specific lipid mediators with G protein-coupled receptors expressed on innate immune cells (e.g. G protein-coupled receptor 32, lipoxin A4 receptor/formyl peptide receptor2, chemokine-like receptor 1, leukotriene B4 receptor type 1 and cabannoid receptor 2) induces cessation of leukocyte infiltration; vascular permeability/edema returns to normal with polymorphonuclear neutrophil death (mostly via apoptosis), the nonphlogistic infiltration of monocyte/macrophages and the removal (by macrophages) of apoptotic polymorphonuclear neutrophils, foreign agents (bacteria) and necrotic debris from the site. While an acute inflammatory response that is resolved in a timely manner prevents tissue injury, inadequate resolution and failure to return tissue to homeostasis results in neutrophil-mediated destruction and chronic inflammation. A better understanding of the complex mechanisms of lipid agonist mediators, cell targets and actions allows us to exploit and develop novel therapeutic strategies to treat human inflammatory diseases, including periodontal diseases.
- Periodontology 2000.Periodontol 2000.2013 Oct;63(1):149-64. doi: 10.1111/prd.12034.
- Inflammation is a protective response essential for maintaining human health and for fighting disease. As an active innate immune reaction to challenge, inflammation gives rise to clinical cardinal signs: rubor, calor, dolor, tumor and functio laesa. Termination of acute inflammation was previously
- PMID 23931059
- Exhaled breath condensate eicosanoid levels associate with asthma and its severity.
- Kazani S, Planaguma A, Ono E, Bonini M, Zahid M, Marigowda G, Wechsler ME, Levy BD, Israel E.SourcePulmonary and Critical Care Division, Department of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. Electronic address: skazani@partners.org.
- The Journal of allergy and clinical immunology.J Allergy Clin Immunol.2013 Sep;132(3):547-53. doi: 10.1016/j.jaci.2013.01.058. Epub 2013 Apr 19.
- BACKGROUND: The relationship between anti-inflammatory lipoxins and proinflammatory leukotrienes might be important in the pathobiology and severity of asthma.OBJECTIVE: We sought to investigate whether exhaled breath condensate (EBC) lipoxin and leukotriene measurements can noninvasively characteri
- PMID 23608729
Japanese Journal
- Expression Analysis of Leukotriene-Inflammatory Gene Interaction Network in Patients with Coronary Artery Disease
- Journal of Atherosclerosis and Thrombosis 21(4), 329-345, 2014
- NAID 130004444722
- Potential New Therapeutic Targets for Pathological Pruritus
- Biological and Pharmaceutical Bulletin 36(8), 1228-1234, 2013
- NAID 130003361502
- Aspirin-Intolerant Asthma (AIA) Assessment Using the Urinary Biomarkers, Leukotriene E4 (LTE4) and Prostaglandin D2 (PGD2) Metabolites
- Allergology International 61(3), 393-403, 2012
- NAID 130004477150
Related Links
- Buy Leukotriene A4-d5 methyl ester, an internal standard for the quantification of LTA4 methyl ester, from Santa Cruz. MF: C21H27D5O3, MW: 337.5 ... Leukotriene A4-d5 methyl ester contains four deuterium atoms at the 19, 19 ...
- Leukotriene A4 | C20H30O3 | CID 5280383 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. ... National ...
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