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Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin) gene.^[1]^[2]^[3]

Function

Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.^[1]

Clinical significance

Defects in the CD43 molecule are associated with the development of Wiskott-Aldrich syndrome.^[4] It also appears in about 25% of intestinal MALTomas.^{[citation needed]} Using immunohistochemistry, CD43 can be demonstrated in the paracortical T-cells of healthy lymph nodes and tonsils; it is also positive in a range of lymphoid and myeloid tumours. Although it is present in over 90% of T-cell lymphomas, it is generally less effective at demonstrating this condition than is CD3 antigen. However, it may be useful as part of a panel to demonstrate B-cell lymphoblastic lymphoma, since the malignant cells in this condition are often CD43 positive, and may be difficult to stain with other antibodies. Because it stains granulocytes and their precursors, it is also an effective marker for myeloid tumours.^[5]

Interactions

CD43 has been shown to interact with EZR^[6] and Moesin.^[6]^[7]

References

^ ^a ^b "Entrez Gene: SPN sialophorin (leukosialin, CD43)".
^ Pallant A, Eskenazi A, Mattei MG, Fournier RE, Carlsson SR, Fukuda M, Frelinger JG (February 1989). "Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16". Proc. Natl. Acad. Sci. U.S.A. 86 (4): 1328–32. Bibcode:1989PNAS...86.1328P. doi:10.1073/pnas.86.4.1328. PMC 286683. PMID 2521952.
^ Shelley CS, Remold-O'Donnell E, Davis AE, Bruns GA, Rosen FS, Carroll MC, Whitehead AS (April 1989). "Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome". Proc. Natl. Acad. Sci. U.S.A. 86 (8): 2819–23. Bibcode:1989PNAS...86.2819S. doi:10.1073/pnas.86.8.2819. PMC 287010. PMID 2784859.
^ Remold-O'Donnell E, Rosen FS (1990). "Sialophorin (CD43) and the Wiskott-Aldrich syndrome". Immunodefic Rev 2 (2): 151–74. PMID 2223062.
^ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. p. 113. ISBN 1-84110-100-1.
^ ^a ^b Serrador JM, Nieto M, Alonso-Lebrero JL, del Pozo MA, Calvo J, Furthmayr H, Schwartz-Albiez R, Lozano F, González-Amaro R, Sánchez-Mateos P, Sánchez-Madrid F (June 1998). "CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts". Blood 91 (12): 4632–44. PMID 9616160.
^ Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S (February 1998). "Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2". J. Cell Biol. 140 (4): 885–95. doi:10.1083/jcb.140.4.885. PMC 2141743. PMID 9472040.

External links

CD43 antigen at the US National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

English Journal

Antigen Presenting Properties of a Myeloid Dendritic-Like Cell in Murine Spleen.

Hey YY1,2, O'Neill HC2.
PloS one.PLoS One.2016 Sep 21;11(9):e0162358. doi: 10.1371/journal.pone.0162358.
This paper distinguishes a rare subset of myeloid dendritic-like cells found in mouse spleen from conventional (c) dendritic cells (DC) in terms of phenotype, function and gene expression. These cells are tentatively named "L-DC" since they resemble dendritic-like cells produced in longterm cultures
PMID 27654936

Blastic plasmacytoid dendritic cell neoplasm: diagnostic criteria and therapeutical approaches.

Pagano L1, Valentini CG1, Grammatico S2, Pulsoni A2.
British journal of haematology.Br J Haematol.2016 Jul;174(2):188-202. doi: 10.1111/bjh.14146. Epub 2016 Jun 5.
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare haematological malignancy derived from the precursors of plamacytoid dendritic cells, with an aggressive clinical course and high frequency of cutaneous and bone marrow involvement. Neoplastic cells express CD4, CD43 (also termed SPN), C
PMID 27264021

A complementary role of multiparameter flow cytometry and high-throughput sequencing for minimal residual disease detection in chronic lymphocytic leukemia: an European Research Initiative on CLL study.

Rawstron AC1, Fazi C2, Agathangelidis A2, Villamor N3, Letestu R4, Nomdedeu J5, Palacio C6, Stehlikova O7, Kreuzer KA8, Liptrot S9, O'Brien D9, de Tute RM1, Marinov I10, Hauwel M11, Spacek M12, Dobber J13, Kater AP13, Gambell P14, Soosapilla A15, Lozanski G16, Brachtl G17,18, Lin K19, Boysen J20, Hanson C20, Jorgensen JL21, Stetler-Stevenson M22, Yuan C22, Broome HE23, Rassenti L23, Craig F24, Delgado J3, Moreno C5, Bosch F6, Egle A17, Doubek M7, Pospisilova S7, Mulligan S25, Westerman D14, Sanders CM26, Emerson R26, Robins HS26, Kirsch I26, Shanafelt T20, Pettitt A19, Kipps TJ23, Wierda WG21, Cymbalista F4, Hallek M8, Hillmen P27, Montserrat E3, Ghia P2,28.
Leukemia.Leukemia.2016 Apr;30(4):929-36. doi: 10.1038/leu.2015.313. Epub 2015 Dec 7.
In chronic lymphocytic leukemia (CLL) the level of minimal residual disease (MRD) after therapy is an independent predictor of outcome. Given the increasing number of new agents being explored for CLL therapy, using MRD as a surrogate could greatly reduce the time necessary to assess their efficacy.
PMID 26639181

Japanese Journal

Distinct signaling pathways are involved in leukosialin (CD43) down-regulation, membrane blebbing, and phospholipid scrambling during neutrophil apoptosis

J. Biol. Chem. 280, 5843-5853, 2005
NAID 30016365419

糖ペプチド合成における問題と進展

Trends in glycoscience and glycotechnology 15(85), 257-273, 2003-09-02
NAID 10013241352

Reduced CD43 Expression on the Neutrophils of MDS Patients Correlates With an Activated Phenotype of These Cells

International journal of hematology 73(4), 483-491, 2001-06-01
NAID 10007321551

Related Pictures

★リンクテーブル★

リンク元	「CD43」「GPL115」「ロイコシアリン」

「CD43」

Sialophorin
Identifiers
Symbols	SPN ; CD43; GALGP; GPL115; LSN
External IDs	OMIM: 182160 MGI: 98384 HomoloGene: 36108 GeneCards: SPN Gene
Gene ontology
Molecular function	• transmembrane signaling receptor activity; • protein binding;
Cellular component	• uropod; • basement membrane; • extracellular space; • plasma membrane; • integral component of plasma membrane; • external side of plasma membrane; • cell surface; • membrane; • extracellular exosome;
Biological process	• response to protozoan; • negative regulation of type IV hypersensitivity; • positive regulation of protein phosphorylation; • chemotaxis; • immune response; • cellular defense response; • negative regulation of cell adhesion; • establishment or maintenance of cell polarity; • signal transduction; • cell surface receptor signaling pathway; • blood coagulation; • T cell costimulation; • positive regulation of T cell proliferation; • negative regulation of T cell proliferation; • positive regulation of tumor necrosis factor biosynthetic process; • defense response to bacterium; • negative thymic T cell selection; • regulation of defense response to virus; • leukocyte migration; • apoptotic signaling pathway;
	Sources: Amigo / QuickGO
Orthologs
	v; t; e;