同: CD43

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/03 05:50:04」(JST)

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Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin) gene.^[1]^[2]^[3]

Function[edit]

Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.^[1]

Clinical significance[edit]

Defects in the CD43 molecule are associated with the development of Wiskott-Aldrich syndrome.^[4] It also appears in about 25% of intestinal MALTomas.^{[citation needed]} Using immunohistochemistry, CD43 can be demonstrated in the paracortical T-cells of healthy lymph nodes and tonsils; it is also positive in a range of lymphoid and myeloid tumours. Although it is present in over 90% of T-cell lymphomas, it is generally less effective at demonstrating this condition than is CD3 antigen. However, it may be useful as part of a panel to demonstrate B-cell lymphoblastic lymphoma, since the malignant cells in this condition are often CD43 positive, and may be difficult to stain with other antibodies. Because it stains granulocytes and their precursors, it is also an effective marker for myeloid tumours.^[5]

Interactions[edit]

CD43 has been shown to interact with EZR^[6] and Moesin.^[6]^[7]

References[edit]

^ ^a ^b "Entrez Gene: SPN sialophorin (leukosialin, CD43)".
^ Pallant A, Eskenazi A, Mattei MG, Fournier RE, Carlsson SR, Fukuda M, Frelinger JG (February 1989). "Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16". Proc. Natl. Acad. Sci. U.S.A. 86 (4): 1328–32. Bibcode:1989PNAS...86.1328P. doi:10.1073/pnas.86.4.1328. PMC 286683. PMID 2521952.
^ Shelley CS, Remold-O'Donnell E, Davis AE, Bruns GA, Rosen FS, Carroll MC, Whitehead AS (April 1989). "Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome". Proc. Natl. Acad. Sci. U.S.A. 86 (8): 2819–23. Bibcode:1989PNAS...86.2819S. doi:10.1073/pnas.86.8.2819. PMC 287010. PMID 2784859.
^ Remold-O'Donnell E, Rosen FS (1990). "Sialophorin (CD43) and the Wiskott-Aldrich syndrome". Immunodefic Rev 2 (2): 151–74. PMID 2223062.
^ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. p. 113. ISBN 1-84110-100-1.
^ ^a ^b Serrador JM, Nieto M, Alonso-Lebrero JL, del Pozo MA, Calvo J, Furthmayr H, Schwartz-Albiez R, Lozano F, González-Amaro R, Sánchez-Mateos P, Sánchez-Madrid F (June 1998). "CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts". Blood 91 (12): 4632–44. PMID 9616160.
^ Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S (February 1998). "Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2". J. Cell Biol. 140 (4): 885–95. doi:10.1083/jcb.140.4.885. PMC 2141743. PMID 9472040.

External links[edit]

CD43 antigen at the US National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

English Journal

Circulating phenotypic B-1 cells are decreased in common variable immunodeficiency and correlate with immunoglobulin M levels.

Kraljevic K, Wong S, Fulcher DA.SourceDepartment of Medicine, University of Sydney, Sydney, Australia.
Clinical and experimental immunology.Clin Exp Immunol.2013 Mar;171(3):278-82. doi: 10.1111/cei.12008.
B-1 cells are innate-like lymphocytes characterized by spontaneous production of 'natural' polyspecific antibodies, often of self-specificity, and thought to be responsible for tissue homeostasis, mucosal protection, maintaining resting serum immunoglobulin (Ig)M levels and for early immunoglobulin
PMID 23379434

Anaplastic large cell lymphoma: a potential pitfall in the differential diagnosis of melanoma.

Pulitzer M, Brady MS, Blochin E, Amin B, Teruya-Feldstein J.SourceDepartments of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. pulitzem@mskcc.org
Archives of pathology & laboratory medicine.Arch Pathol Lab Med.2013 Feb;137(2):280-3. doi: 10.5858/arpa.2011-0532-CR.
The diagnosis of metastatic melanoma can be complicated by absent characteristic cytology, melanin, or antigen expression in a suspect tumor, putting the pathologist at risk for incorrectly diagnosing recurrent melanoma while missing a second malignancy. We report a 69-year-old man with a history of
PMID 23368872

Galectin-1 promotes human neutrophil migration.

Auvynet C, Moreno S, Melchy E, Coronado-Martínez I, Montiel JL, Aguilar-Delfin I, Rosenstein Y.SourceDepartamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnologia, Universidad Nacional Autónoma de México, Avenida Universidad 2001, Col Chamilpa, Cuernavaca, Morelos 62210, Mexico.
Glycobiology.Glycobiology.2013 Jan;23(1):32-42. doi: 10.1093/glycob/cws128. Epub 2012 Aug 31.
An important step of innate immune response is the recruitment of polymorphonuclear leukocytes (PMN) to injured tissues through chemotactic molecules. Galectins, a family of endogenous lectins, participate in numerous functions such as lymphoid cell migration, homing, cell-cell and cell-matrix inter
PMID 22942212

Japanese Journal

Reduced CD43 Expression on the Neutrophils of MDS Patients Correlates With an Activated Phenotype of These Cells

KYRIAKOU Despina,ALEXANDRAKIS Michael G.,KYRIAKOU Elias S.,LIAPI Dimitra,KOURELIS Taxiarchis V.,MAVROMANOLAKIS M.,VLACHONIKOLIS Ioannis,ELIAKIS Polyvios
International journal of hematology 73(4), 483-491, 2001-06-01
NAID 10007321551

汎発性の湿疹病変を呈した成人Wiskott-Aldrich症候群の1例

篠原三秀,田中洋一,片山一朗,近藤達郎
日本皮膚科学会雑誌 109(5), 775-779, 1999-04-20
NAID 10007732040

Signal transduction via CD43 (leukosialin, sialophorin) and associated biological effects in human mast cell line (HMC-1)

BABINA M.
Biochem. Biophys. Res. Commun. 243, 163-169, 1998
NAID 30017792498

Related Pictures

Western Blot: CD43/Sialophorin Antibody SPN (sialophorin) sialophorin produces low igm levels and SialylLewisXmethylglycoside sialophorin k06477 sialophorin hsa05145 hsa05034 Alcoholism - Homo sapiens (human Thrombocytopenia, Wiskott Aldrich Syndrome

★リンクテーブル★

リンク元	「GPL115」「シアロホリン」

「GPL115」

Sialophorin
Identifiers
Symbols	SPN (; CD43; GALGP; GPL115; LSN)
External IDs	OMIM: 182160 MGI: 98384 HomoloGene: 36108 GeneCards: SPN Gene
Gene Ontology
Molecular function	• transmembrane signaling receptor activity; • bacterial cell surface binding;
Cellular component	• uropod; • basement membrane; • extracellular space; • plasma membrane; • integral to plasma membrane; • external side of plasma membrane; • cell surface;
Biological process	• response to protozoan; • negative regulation of type IV hypersensitivity; • chemotaxis; • immune response; • cellular defense response; • negative regulation of cell adhesion; • establishment or maintenance of cell polarity; • signal transduction; • cell surface receptor signaling pathway; • blood coagulation; • T cell costimulation; • positive regulation of T cell proliferation; • negative regulation of T cell proliferation; • positive regulation of tumor necrosis factor biosynthetic process; • defense response to bacterium; • negative thymic T cell selection; • regulation of defense response to virus; • leukocyte migration;
	Sources: Amigo / QuickGO
Orthologs
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　　[★]

同: CD43、シアロホリン sialophorin、ロイコシアリン leukosialin

「シアロホリン」

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英: sialophorin
関: GPL115

[entrez-1] "Entrez Gene: SPN sialophorin (leukosialin, CD43)".

[pmid2521952-2] Pallant A, Eskenazi A, Mattei MG, Fournier RE, Carlsson SR, Fukuda M, Frelinger JG (February 1989). "Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16". Proc. Natl. Acad. Sci. U.S.A. 86 (4): 1328–32. Bibcode:1989PNAS...86.1328P. doi:10.1073/pnas.86.4.1328. PMC 286683. PMID 2521952.

[pmid2784859-3] Shelley CS, Remold-O'Donnell E, Davis AE, Bruns GA, Rosen FS, Carroll MC, Whitehead AS (April 1989). "Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome". Proc. Natl. Acad. Sci. U.S.A. 86 (8): 2819–23. Bibcode:1989PNAS...86.2819S. doi:10.1073/pnas.86.8.2819. PMC 287010. PMID 2784859.

[pmid2223062-4] Remold-O'Donnell E, Rosen FS (1990). "Sialophorin (CD43) and the Wiskott-Aldrich syndrome". Immunodefic Rev 2 (2): 151–74. PMID 2223062.

[Leong-5] Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. p. 113. ISBN 1-84110-100-1.

[pmid9616160-6] Serrador JM, Nieto M, Alonso-Lebrero JL, del Pozo MA, Calvo J, Furthmayr H, Schwartz-Albiez R, Lozano F, González-Amaro R, Sánchez-Mateos P, Sánchez-Madrid F (June 1998). "CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts". Blood 91 (12): 4632–44. PMID 9616160.

[pmid9472040-7] Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S (February 1998). "Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2". J. Cell Biol. 140 (4): 885–95. doi:10.1083/jcb.140.4.885. PMC 2141743. PMID 9472040.

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sialophorin