WordNet

with the wind abaft the beam; "a ship sailing large"
a garment size for a large person
above average in size or number or quantity or magnitude or extent; "a large city"; "set out for the big city"; "a large sum"; "a big (or large) barn"; "a large family"; "big businesses"; "a big expenditure"; "a large number of newspapers"; "a big group of scientists"; "large areas of the world" (同)big
at a distance, wide of something (as of a mark)
fairly large or important in effect; influential; "played a large role in the negotiations"
having broad power and range and scope; "taking the large view"; "a large effect"; "a large sympathy"
small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
any malignant tumor derived from epithelial tissue; one of the four major types of cancer

PrepTutorEJDIC

(同じ種類のものと比較して,形・体積・数量などが)『大きい』,多い,広い / (考えなどが)広範囲な,幅の広い,寛大な / 大きく / 自慢して,誇大に
(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
がん,がん腫

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/17 22:35:47」(JST)

wiki en

Large-cell carcinoma (LCC) is a heterogeneous group of undifferentiated malignant neoplasms that lack the cytologic and architectural features of small cell carcinoma and glandular or squamous differentiation. LCC is categorized as a type of NSCLC (Non-Small Cell Carcinoma) which originates from epithelial cells of the lung.[1]

Incidence

Pie chart showing incidence of large-cell lung cancer (shown in green at upper left) as compared to other lung cancer types, with fractions of smokers versus non-smokers shown for each type.^[1]

In most series, LCLC's comprise between 5% and 10% of all lung cancers.

According to the Nurses' Health Study, the risk of large cell lung carcinoma increases with a previous history of tobacco smoking, with a previous smoking duration of 30 to 40 years giving a relative risk of approximately 2.3 compared to never-smokers, and a duration of more than 40 years giving a relative risk of approximately 3.6.^[2]

Another study concluded that cigarette smoking is the predominant cause of large cell lung cancer. It estimated that the odds ratio associated with smoking two or more packs/day for current smokers is 37.0 in men and 72.9 in women.^[3]

Diagnosis

LCC is, in effect, a "diagnosis of exclusion", in that the tumor cells lack light microscopic characteristics that would classify the neoplasm as a small-cell carcinoma, squamous-cell carcinoma, adenocarcinoma, or other more specific histologic type of lung cancer.

LCC is differentiated from small-cell lung carcinoma (SCLC) primarily by the larger size of the anaplastic cells, a higher cytoplasmic-to-nuclear size ratio, and a lack of "salt-and-pepper" chromatin.

Classification

The newest revisions of the World Health Organization (WHO) "Histological Typing of Lung Cancer schema" include several variants of LCC, including:

Giant-cell carcinoma of the lung
Basaloid large cell carcinoma of the lung
Clear cell carcinoma of the lung
Lymphoepithelioma-like carcinoma of the lung
Large-cell lung carcinoma with rhabdoid phenotype
Large cell neuroendocrine carcinoma of the lung

Large-cell neuroendocrine carcinoma (LCNEC)

One clinically significant subtype is "large-cell neuroendocrine carcinoma" (LCNEC),^[4] which is believed to derive from neuroendocrine cells.^[5]

In addition, a "subvariant", called "combined large-cell neuroendocrine carcinoma" (or c-LCNEC), is recognized under the new system. To be designated a c-LCNEC, the tumor must contain at least 10% LCNEC cells, in combination with at least 10% of other forms of NSCLC.

Pathology images

Clinically

Patients typically present with a non-productive cough and weight loss.

References

^ Smokers defined as current or former smoker of more than 1 year of duration. See image page in Commons for percentages in numbers. Reference:
- Table 2 in: Kenfield SA, Wei EK, Stampfer MJ, Rosner BA, Colditz GA (2008). "Comparison of aspects of smoking among the four histological types of lung cancer.". Tob Control. 17 (3): 198–204. doi:10.1136/tc.2007.022582. PMC 3044470. PMID 18390646.
^ Kenfield, S. A.; Wei, E. K.; Stampfer, M. J.; Rosner, B. A.; Colditz, G. A. (2008). "Comparison of aspects of smoking among the four histological types of lung cancer". Tobacco Control. 17 (3): 198–204. doi:10.1136/tc.2007.022582. PMC 3044470. PMID 18390646.
^ Muscat, JE; Stellman, SD; Zhang, ZF; Neugut, AI; Wynder, EL (July 1997). "Cigarette smoking and large cell carcinoma of the lung.". Cancer Epidemiology, Biomarkers & Prevention. 6 (7): 477–80. PMID 9232332.
^ Fernandez FG, Battafarano RJ (October 2006). "Large-cell neuroendocrine carcinoma of the lung" (PDF). Cancer Control. 13 (4): 270–5. PMID 17075564.
^ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 762. ISBN 0-7216-0187-1.

External links

[1]. World Health Organization Histological Classification of Lung and Pleural Tumours. 4th Edition.

UpToDate Contents

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1. 肺悪性腫瘍の病理 pathology of lung malignancies
2. 肺の大細胞神経内分泌癌 large cell neuroendocrine carcinoma of the lung
3. ドライバー変異が認められない進行非小細胞肺癌の初期マネージメントのための全身療法 systemic therapy for the initial management of advanced non small cell lung cancer without a driver mutation
4. 腎細胞癌の疫学、病理、および病因 epidemiology pathology and pathogenesis of renal cell carcinoma
5. ALK陽性未分化大細胞型リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of anaplastic large cell lymphoma alk positive

English Journal

The development of large-cell carcinoma in the wall of a giant bulla complicated by hemorrhage.

Nakamura S1, Kawaguchi K2, Fukui T2, Fukumoto K2, Okasaka T2, Yokoi K2.
Surgical case reports.Surg Case Rep.2016 Dec;2(1):22. doi: 10.1186/s40792-016-0151-8. Epub 2016 Mar 10.
There were a few reports of patients with lung cancer developing at the wall of giant bullae complicated with hemorrhage. A 40-year-old male with complaints of hemoptysis was referred to our hospital, and a solitary pulmonary mass was pointed out on his chest roentgenogram. Computed tomography (CT)
PMID 26964998

Analgesic use and risk of renal cell carcinoma: A case-control, cohort and meta-analytic assessment.

Karami S1, Daughtery SE2, Schwartz K3,4, Davis FG5, Ruterbusch JJ3,4, Wacholder S1, Graubard BI1, Berndt SI1, Hofmann JN1, Purdue MP1, Moore LE1, Colt JS1.
International journal of cancer.Int J Cancer.2016 Aug 1;139(3):584-92. doi: 10.1002/ijc.30108. Epub 2016 Apr 9.
Analgesics are the most commonly consumed drugs worldwide. Evidence that analgesics increase kidney cancer risk has been mixed. We investigated the association between renal cell carcinoma (RCC) and analgesic use in a large population-based case-control study and a post-trial observational cohort st
PMID 27009534

Japanese Journal

A case of large cell neuroendocrine carcinoma of the esophagogastric junction

Fukuchi Minoru,Sakurai Shinji,Tsukagoshi Ritsuko [他]
Esophagus : official journal of the Japan Esophageal Society 12(3), 295-299, 2015-07
NAID 40020539718

症例報告子宮頸部に発生した大細胞神経内分泌癌の1例

村田周子,橋本和法,岡田純奈 [他]
東京産科婦人科学会会誌 64(2), 165-169, 2015-04
NAID 40020542706

Related Pictures

Pulmonary Cancer Path Flashcards at University of Pennsylvania - StudyBlue Pathology Outlines - Large cell Carcinoma polmonare a grandi cellule - Wikipedia Carcinoma, Large Cell Large cell neuroendocrine carcinoma | Flickr - Photo Sharing! Non–Small-Cell Lung Cancer Pathology | Cancer Network Large Cell Carcinoma Undifferentiated Type Of An Adult Male Lung He Stain Lm X100