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Bruch's membrane
Details
Identifiers
Latin
lamina basalis choroideae
Anatomical terminology
[edit on Wikidata]
Bruch's membrane is the innermost layer of the choroid. It is also called the vitreous lamina, because of its glassy microscopic appearance.
It is 2–4 μm thick.[1]
Contents
1Layers
2Embryology
3Pathology
4Eponym
5References
6External links
Layers
Illustration of Bruch's Membrane
Bruch's membrane consists of five layers (from inside to outside):[1][2]
the basement membrane of the retinal pigment epithelium
the inner collagenous zone
a central band of elastic fibers
the outer collagenous zone
the basement membrane of the choriocapillaris
The retinal pigment epithelium transports metabolic waste from the photoreceptors across Bruch's membrane to the choroid.
Embryology
Bruch's membrane is present by midterm in fetal development as an elastic sheet.
Pathology
Bruch's membrane thickens with age, slowing the transport of metabolites. This may lead to the formation of drusen in age-related macular degeneration.[3] There is also a buildup of deposits (Basal Linear Deposits or BLinD and Basal Lamellar Deposits BLamD) on and within the membrane, primarily consisting of phospholipids. The accumulation of lipids appears to be greater in the central fundus than in the periphery. This build up seems to fragment the membrane into a lamellar structure more like puff-pastry than a barrier. Inflammatory and neovascular mediators can then invite choroidal vessels to grow into and beyond the fragmented membrane. This neovascular membrane destroys the architecture of the outer retina and leads to sudden loss of central vision – wet age related macular degeneration.
Pseudoxanthoma elasticum, myopia and trauma can also cause defects in Bruch's membrane which may lead to choroidal neovascularization. Alport's Syndrome, a genetic disorder affecting the alpha(IV) collagen chains, can also lead to defects in the Bruch membrane such as 'dot and fleck' retinopathy.
Eponym
Bruch's membrane was named after the German anatomist Karl Wilhelm Ludwig Bruch.
References
^ abLee, Christina J.; Vroom, Jonathan A.; Fishman, Harvey A.; Bent, Stacey F. (Mar 2006). "Determination of human lens capsule permeability and its feasibility as a replacement for Bruch's membrane". Biomaterials. 27 (8): 1670–1678. doi:10.1016/j.biomaterials.2005.09.008. PMID 16199085.
^eOptha website: Anatomy of Uvea by Parthopratim Dutta Majumder
^Young R (Mar 1987). "Pathophysiology of age-related macular degeneration". Surv Ophthalmol. 31 (5): 291–306. doi:10.1016/0039-6257(87)90115-9. PMID 3299827.
…epithelial lining of the bladder. The urothelium is the site of origin for bladder carcinomas. Lamina propria – The lamina propria (subepithelial connective tissue) is separated from the urothelium by a thin basement …
…potentially harmful nondigested proteins may reach the lamina propria and enter the portal circulation. Dendritic cells – Dendritic cells in the lamina propria can extend dendrites between intestinal epithelial …
…specific. The diagnosis is made on the basis of histologic finding of fibromuscular obliteration of the lamina propria. The endoscopic findings range from mucosal erythema to single or multiple ulcers and polypoid/mass …
…hyperplastic-appearing glands with a mixed inflammatory infiltrate in the lamina propria and fibromuscular obliteration of the lamina propria There are varying degrees of surface ulceration and a characteristic …
English Journal
The fate of the arachnoid villi in humans.
Krmpotić-Nemanić J, Vinter I, Kelović Z, Suknaić S.
Collegium antropologicum. 2003 Dec;27(2)611-6.
Villi arachnoidales undergoes in the course of life changes in relation to the skull bones and sinuses. Our aim was to determine the relations of the villi arachnoidales to the skull bone and/or sinuses from the neonatal period to adults. The investigations were performed on collection of 50 disarti
Posterior decompensation syndrome: macular failure versus senile macular degeneration.
Havener WH, Benes SC.
Annals of ophthalmology. 1986 Sep;18(9)271-2.
Macular cone death in adults is caused by failure of the system that carries away the retinal biologic wastes. This failure may be termed the posterior decompensation syndrome, a name intended to convey the dynamic concept of imbalance between formation and elimination of waste. Because of centripet
Among the various forms of juvenile macular degeneration, one can distinguish those that primarily involve: 1. The neuro-epithelium: Stargardt's disease; dominant juvenile degeneration; central or pericentral pigmentary retinopathy, progressive dystrophy of the cones and cystoid macular oedema. 2. T
… Morphological studies on the ciliary muscles, laminavitrea and ciliary vessels were made, and the results are as follows: 1. … Fine fibrils and nuclei were seen in the inner sheet of the laminavitrea. … When the ciliary muscles contract the laminavitrea puts pressure on the vitreous, so that the anterior chamber becomes narrow, and aquious outflow is improved. …
… Morphological studies on the ciliary muscles, laminavitrea and ciliary vessels were made, and the results are as follows:<br>1. … Fine fibrils and nuclei were seen in the inner sheet of the laminavitrea. … When the ciliary muscles contract the laminavitrea puts pressure on the vitreous, so that the anterior chamber becomes narrow, and aquious outflow is improved.<br>3. …
… stimmt der Rupturtheorie der Laminavitrea nach Kofler zu, weil die Pigmentstreifen nach der volligen Adsorbierung des Blutes nicht verandert blieben, und das ist der Nachweis, dass die Pigmentstreifen nicht durch die Blutung hervorgerufen wurden. …
lamina den´sa an electron-dense layer of the basal lamina, consisting mainly of collagen fibrils and proteoglycans; it closely follows the plasma membrane of the basal aspect of the adjacent cell layer, from which it is separated by the lamina lucida ...
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Find out information about lamina vitrea. 1. a thin plate or layer, esp of bone or mineral 2. Botany the flat blade of a leaf, petal, or thallus blade A thin sheet or layer of tissue; a scalelike... Explanation of lamina vitrea Lamina vitrea ...