WordNet

a thin pliable sheet of material
a pliable sheet of tissue that covers or lines or connects the organs or cells of animals or plants (同)tissue layer
German composer (1838-1920) (同)Max Bruch

PrepTutorEJDIC

(生物の)膜,皮膜

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/12 04:03:25」(JST)

wiki en

Bruch's membrane is the innermost layer of the choroid. It is also called the vitreous lamina, because of its glassy microscopic appearance. It is 2–4 μm thick.^[1]

Layers

Bruch's membrane consists of five layers (from inside to outside):^[1]^[2]

the basement membrane of the retinal pigment epithelium
the inner collagenous zone
a central band of elastic fibers
the outer collagenous zone
the basement membrane of the choriocapillaris

The retinal pigment epithelium transports metabolic waste from the photoreceptors across Bruch's membrane to the choroid.

Embryology

Bruch's membrane is present by midterm in fetal development as an elastic sheet.

Pathology

Bruch's membrane thickens with age, slowing the transport of metabolites. This may lead to the formation of drusen in age-related macular degeneration.^[3] There is also a buildup of deposits (Basal Linear Deposits or BLinD and Basal Lamellar Deposits BLamD) on and within the membrane, primarily consisting of phospholipids. The accumulation of lipids appears to be greater in the central fundus than in the periphery. This build up seems to fragment the membrane into a lamellar structure more like puff-pastry than a barrier. Inflammatory and neovascular mediators can then invite choroidal vessels to grow into and beyond the fragmented membrane. This neovascular membrane destroys the architecture of the outer retina and leads to sudden loss of central vision - wet age related macular degeneration.

Pseudoxanthoma elasticum, myopia and trauma can also cause defects in Bruch's membrane which may lead to choroidal neovascularization. Alport's Syndrome, a genetic disorder affecting the alpha(IV) collagen chains, can also lead to defects in the Bruch membrane such as 'dot and fleck' retinopathy.

Eponym

Bruch's membrane was named after the German anatomist Karl Wilhelm Ludwig Bruch.

References

^ ^a ^b Lee, Christina J.; Vroom, Jonathan A.; Fishman, Harvey A.; Bent, Stacey F. (Mar 2006). "Determination of human lens capsule permeability and its feasibility as a replacement for Bruch's membrane". Biomaterials 27 (8): 1670–1678. doi:10.1016/j.biomaterials.2005.09.008. PMID 16199085.
^ eOptha website: Anatomy of Uvea by Parthopratim Dutta Majumder
^ Young RW (Mar 1987). "Pathophysiology of age-related macular degeneration". Surv Ophthalmol 31 (5): 291–306. doi:10.1016/0039-6257(87)90115-9. PMID 3299827.

External links

Pictures at National Eye Institute

This article about the eye is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. C3糸球体腎症：デンスデポジット病およびC3糸球体腎炎 c3 glomerulopathies dense deposit disease and c3 glomerulonephritis
2. 血液-血液透析膜の相互作用に関与する生化学的機序 biochemical mechanisms involved in blood hemodialysis membrane interactions
3. 赤血球細胞膜の動態および機構 red blood cell membrane dynamics and organization
4. ライソゾーム膜蛋白質2欠損症（糖原病IIb型、ダノン病） lysosome associated membrane protein 2 deficiency glycogen storage disease iib danon disease
5. 補体系の制御因子および受容体 regulators and receptors of the complement system

English Journal

A Bruch's membrane substitute fabricated from silk fibroin supports the function of retinal pigment epithelial cells in vitro.

Shadforth AM1,2,3, Suzuki S3, Theodoropoulos C2,3, Richardson NA1,2,3, Chirila TV3,4,5,6,7, Harkin DG1,2,3.
Journal of tissue engineering and regenerative medicine.J Tissue Eng Regen Med.2015 Oct 9. doi: 10.1002/term.2089. [Epub ahead of print]
Silk fibroin provides a promising biomaterial for ocular tissue reconstruction, including the damaged outer blood-retinal barrier of patients afflicted with age-related macular degeneration (AMD). The aim of the present study was to evaluate the function of retinal pigment epithelial (RPE) cells in
PMID 26449636

SWEPT SOURCE OCT ANGIOGRAPHY OF NEOVASCULAR MACULAR TELANGIECTASIA TYPE 2.

Zhang Q1, Wang RK, Chen CL, Legarreta AD, Durbin MK, An L, Sharma U, Stetson PF, Legarreta JE, Roisman L, Gregori G, Rosenfeld PJ.
Retina (Philadelphia, Pa.).Retina.2015 Oct 8. [Epub ahead of print]
BACKGROUND/PURPOSE: To image subretinal neovascularization in proliferative macular telangiectasia Type 2 (MacTel2) using swept source optical coherence tomography based microangiography (OMAG).METHODS: Patients with macular telangiectasia Type 2 were enrolled in a prospective, observational study k
PMID 26457402

Intravitreal Bevacizumab for Traumatic Choroidal Rupture.

Kim M1, Kim JH, Seo Y, Koh HJ, Lee SC.
Optometry and vision science : official publication of the American Academy of Optometry.Optom Vis Sci.2015 Oct;92(10):e363-7. doi: 10.1097/OPX.0000000000000677.
PURPOSE: To report a case of visual loss associated with traumatic choroidal rupture after blunt ocular trauma that was successfully treated with an early intravitreal bevacizumab injection despite the absence of choroidal neovascularization (CNV).CASE REPORT: A 14-year-old boy presented with visual
PMID 26367340

Japanese Journal

Acquired focal choroidal excavation associated with multiple evanescent white dot syndrome: observations at onset and a pathogenic hypothesis

Hashimoto Yuki,Saito Wataru,Noda Kousuke,Ishida Susumu
BMC ophthalmology 14, 135, 2014-11-20
… EDI-OCT showed the loss of photoreceptor inner segment/outer segment junction line, detachment between the retinal pigment epithelium (RPE) and Bruch's membrane, and dome-shaped, moderately reflective, focal photoreceptor-layer lesions corresponding to perifoveal white dots. … The region with pigment epithelium detachment involved RPE/Bruch's membrane ruptures. …
NAID 120005567730

Real-time imaging of rabbit retina with retinal degeneration by using spectral-domain optical coherence tomography.

Muraoka Yuki,Ohashi Ikeda Hanako,Nakano Noriko,Hangai Masanori,Toda Yoshinobu,Okamoto-Furuta Keiko,Kohda Haruyasu,Kondo Mineo,Terasaki Hiroko,Kakizuka Akira,Yoshimura Nagahisa
PloS one 7(4), 2012-04
… The thickness of the outer nuclear layer (ONL) and between the external limiting membrane and Bruch's membrane (ELM–BM) were reduced in RP rabbits around the visual streak, compared to WT rabbits even at 4 weeks of age, and the differences increased with age. …
NAID 120004108231