WordNet
- used up; "time is up"
- raise; "up the ante"
- extending or moving toward a higher place; "the up staircase"; "a general upward movement of fish" (同)upward
- to a later time; "they moved the meeting date up"; "from childhood upward" (同)upwards, upward
- spatially or metaphorically from a lower to a higher position; "look up!"; "the music surged up"; "the fragments flew upwards"; "prices soared upwards"; "upwardly mobile" (同)upwards, upward, upwardly
- (used of computers) operating properly; "how soon will the computers be up?"
- (usually followed by `on or `for'
- being or moving higher in position or greater in some value; being above a former position or level; "the anchor is up"; "the sun is up"; "he lay face up"; "he is up by a pawn"; "the market is up"; "the corn is up"
- nearer to the speaker; "he walked up and grabbed my lapels"
- open; "the windows are up"
- to a higher intensity; "he turned up the volume"
- to a more central or a more northerly place; "was transferred up to headquarters"; "up to Canada for a vacation"
- rap with the knuckles; "knock on the door"
- the act of hitting vigorously; "he gave the table a whack" (同)belt, rap, whack, whang
- a vigorous blow; "the sudden knock floored him"; "he took a bash right in his face"; "he got a bang on the head" (同)bash, bang, smash, belt
- the sound of knocking (as on a door or in an engine or bearing); "the knocking grew louder" (同)knocking
- negative criticism (同)roast
- a bad experience; "the school of hard knocks"
- find fault with; express criticism of; point out real or perceived flaws; "The paper criticized the new movie"; "Dont knock the food--its free" (同)criticize, criticise, pick apart
- deliver a sharp blow or push :"He knocked the glass clear across the room" (同)strike hard
- (chiefly British) of or appropriate to the upper classes especially in language use
PrepTutorEJDIC
- 妊娠させる・はらませる/打ち上げる、突き上げる、払い上げる/ドアをたたいて(寝ている人を)起こす、戸別訪問をする/ボールを乱打する、練習の打ち合いをする/痛めつける、攻撃する、疲れさせる、くたくたに疲れる、ヘトヘトにする、ヘトヘトになる、病気になる/大急ぎで作る、雑に作る、間に合わせに組み立てる/得点する、点を稼ぐ、~の票を獲得しようとする/傷つける、損害を与える、痛める、ぶっ壊す/衝突する、薬を注射する
- 《上への動作》『上へ』,上のほうへ / 《上の位置》『上に』,上のほうで / 『起こして』,立てて,直立して / (地図・紙面などの)『上へ(に)』,北のほうへ(に) / (遠くから)『近くへ,中心へ』;(周辺から)中心へ;(川下から)川上へ;(地方から)都会へ / (大きさ・量・価値・地位などが)『上のほうへ』,高く / (話者,話題の場所へ)『近づいて』,追いついて / 『活動して』,活動状態に / (物事・人が)現れて・起こって / 『すっかり』,完全に,終わって,…し尽くして / 保管(貯蔵)して;くるんだ(閉ざした)状態に / 《動詞を省略した命令文で》 / (野球・クリケットで)打席へ / (競技で)勝ち越して / (対抗の競技で)おのおの / 《移動・位置》『…の高いほうへ』,をのぼって;…の上のほうに / (川の)『上流へ』;(流れ・風)に逆らって;…の内陸(奥地)のほうへ / (自分が今いる所,またはある地点から前方へ)『…に沿って』 / 『上へ向かう』,(列車などが)上りの;上り坂の,(情勢などが)上向きの / 上り,上昇,上り坂 / 上昇気運,向上,幸運 / 上りの列車(バス・エレボーターなど) / 値上がり / …‘を'持ち上げる / …‘を'増大する,〈賃金・物価など〉‘を'引き上げる / 〈人〉‘を'昇進させる / 立ち上がる,起き上がる / 《and を伴って》急に(突然)…する
- (音がするくらい強く)…‘を'『たたく』,『打つ』,なぐる / (…に)〈体・体の一部〉‘を'『ぶつける』《+『名』+『against』(『on』)+『名』》 / 《副詞[句]を伴って》…‘を'打って(ある状態などに)する / 〈穴など〉‘を'打ってあける / 《俗》…‘を'けなす,こきおろす / 《英俗》…‘を'びっくりさせる,‘に'ショックを与える / (…を)コツコツとたたく《+『on』(『at』)+『名』》 / (…に)ぶつかる,衝突する《+『against』(『into』)+『名』》 / (故障などで)〈エンジンなどが〉ガタガタいう,ノッキングを起こす / (…を)『打つこと』,(…に対する)一打(撃)《+『on』+『名』》 / (…を)ノックすること(音)《+『on』(『at』)+『名』》 / (エンジンの)ノック,ノッキング / 《話》不運;悪評
UpToDate Contents
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English Journal
- Programmed nanoparticles for combined immunomodulation, antigen presentation and tracking of immunotherapeutic cells.
- Heo MB, Lim YT.SourceGraduate School and Department of Analytical Science and Technology, Chungnam National University, Daejeon 305-764, South Korea.
- Biomaterials.Biomaterials.2014 Jan;35(1):590-600. doi: 10.1016/j.biomaterials.2013.10.009. Epub 2013 Oct 11.
- We report programmed nanoparticles (pNPs) that can tailor the immunotherapeutic function of primary bone marrow-derived dendritic cells (BMDCs) by ex vivo combined immunomodulation and track the in vivo migration of them after injection into body. Because DCs are the most effective antigen-present
- PMID 24125775
- HEXIM1 down-regulates hypoxia-inducible factor-1α protein stability.
- Yeh IJ, Ogba N, Bensigner H, Welford SM, Montano MM.Source*Department of Pharmacology, Division of General Medical Science and Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, U.S.A.
- The Biochemical journal.Biochem J.2013 Dec 1;456(2):195-204. doi: 10.1042/BJ20130592.
- We have previously reported on the inhibition of HIF-1α (hypoxia-inducible factor α)-regulated pathways by HEXIM1 [HMBA (hexamethylene-bis-acetamide)-inducible protein 1]. Disruption of HEXIM1 activity in a knock-in mouse model expressing a mutant HEXIM1 protein resulted in increased susceptibilit
- PMID 24015760
- Lycopene production in recombinant strains of Escherichia coli is improved by knockout of the central carbon metabolism gene coding for glucose-6-phosphate dehydrogenase.
- Zhou Y, Nambou K, Wei L, Cao J, Imanaka T, Hua Q.SourceState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
- Biotechnology letters.Biotechnol Lett.2013 Dec;35(12):2137-45. doi: 10.1007/s10529-013-1317-0. Epub 2013 Sep 24.
- Genetic manipulation was undertaken in order to understand the mechanism involved in the heterologous synthesis of lycopene in Escherichia coli. Knockout of the central carbon metabolic gene zwf (glucose-6-phosphate dehydrogenase) resulted in the enhancement of lycopene production (above 130 % rela
- PMID 24062132
Japanese Journal
- Beam-induced graphitic carbon cage transformation from sumanene aggregates
- Fujita Jun-ichi,Tachi Masashi,Murakami Katsuhisa,Sakurai Hidehiro,Morita Yuki,Higashibayashi Shuhei,Takeguchi Masaki,藤田 淳一,村上 勝久
- Applied physics letters 104(4), 043107, 2014-01
- … The transformation sequence suggested that the cage was constructed accompanied by the dynamical movement of the transiently linked sumanene molecules in order to pile up inside the shell. … Thus, bond excitation in the sumanene molecules rather than a knock-on of carbon atoms seems to be the main cause of the cage transformation. …
- NAID 120005373274
- ATL54, a ubiquitin ligase gene related to secondary cell wall formation, is transcriptionally regulated by MYB46
- Noda Soichiro,Yamaguchi Masatoshi,Tsurumaki Yuta,Takahashi Yoshinori,Nishikubo Nobuyuki,Hattori Takefumi,Demura Taku,Suzuki Shiro,Umezawa Toshiaki
- Plant Biotechnology 30(5), 503-509, 2013
- … The ATL54 gene is co-expressed with secondary wall-associated genes, and the knock-out of ATL54 up-regulates the expression of cellulose, lignin, and xylan biosynthetic genes in apical stem portions of four-week-old plants. …
- NAID 130003382501
- ATL54, a RING-H2 domain protein selected by a gene co-expression network analysis, is associated with secondary cell wall formation in Arabidopsis
- Noda Soichiro,Takahashi Yoshinori,Tsurumaki Yuta [他],Yamamura Masaomi,Nishikubo Nobuyuki,Yamaguchi Masatoshi,Sakurai Nozomu,Hattori Takefumi,Suzuki Hideyuki,Demura Taku,Shibata Daisuke,Suzuki Shiro,Umezawa Toshiaki
- Plant Biotechnology 30(2), 169-177, 2013
- … The expression of several biosynthetic genes of cellulose, lignin, and xylan in apical portions of inflorescence stems was up-regulated by ATL54 knock-out. … The expression of Xylem Cysteine Peptidase1 (XCP1), which participates in the programmed cell death process of xylem tracheary elements, was down-regulated in middle stem portions of both ATL54-knock-out and ATL54-overexpressed mutants. …
- NAID 130003362429
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