killer cell immunoglobulin-like receptor

キラー細胞免疫グロブリン様受容体

関

killer inhibitory receptor、KIR receptor

WordNet

1. overwhelm with hilarity, pleasure, or admiration; "The comedian was so funny, he was killing me!"
2. cause to cease operating; "kill the engine"
3. destroy a vitally essential quality of or in; "Eating artichokes kills the taste of all other foods"
4. tire out completely; "The daily stress of her work is killing her"
5. the destruction of an enemy plane or ship or tank or missile; "the pilot reported two kills during the mission"
6. mark for deletion, rub off, or erase; "kill these lines in the Presidents speech" (同)obliterate, wipe_out
7. thwart the passage of; "kill a motion"; "he shot down the students proposal" (同)shoot down, defeat, vote down, vote out
8. be fatal; "cigarettes kill"; "drunken driving kills"
9. be the source of great pain for; "These new shoes are killing me!"
10. cause the death of, without intention; "She was killed in the collision of three cars"
11. cause to die; put to death, usually intentionally or knowingly; "This man killed several people when he tried to rob a bank"; "The farmer killed a pig for the holidays"
12. deprive of life; "AIDS has killed thousands in Africa"
13. hit with great force; "He killed the ball"
14. hit with so much force as to make a return impossible, in racket games; "She killed the ball"
15. want to have; "Id like a beer now!"
16. a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
17. a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
18. equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
19. resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
20. be fond of; "I like my nephews"
21. feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
22. find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
23. small room in which a monk or nun lives (同)cubicle
24. a device that delivers an electric current as the result of a chemical reaction (同)electric cell
25. a room where a prisoner is kept (同)jail cell, prison cell
26. (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
27. any small compartment; "the cells of a honeycomb"
28. a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
29. someone who causes the death of a person or animal (同)slayer
30. a difficulty that is hard to deal with; "that exam was a real killer"
31. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

1. 〈人・動物〉‘を'『殺す』,死亡させる / 〈植物〉‘を'枯らす / …‘を'だめにする,失わせる / 《話》…‘を'ひどく痛ませる(疲れさせる,不快にさせる) / 〈時間〉‘を'つぶす / 〈記事など〉‘を'没にする,握りつぶす / 人殺しをする / 殺すこと;(特に狩猟の)獲物をしとめること / (猟の)獲物
2. …‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
3. (外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
4. (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
5. 殺人者;屠殺(とさつ)者;殺し屋
6. =sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/21 14:11:51」(JST)

wiki en

[Wiki en表示]

Killer-cell immunoglobulin-like receptors (KIRs), are a family of cell surface proteins found on important cells of the immune system called natural killer (NK) cells. They regulate the killing function of these cells by interacting with MHC class I molecules, which are expressed on all cell types. This interaction allows them to detect virally infected cells or tumor cells that have a characteristic low level of Class I MHC on their surface. Most KIRs are inhibitory, meaning that their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the ability to activate cells. KIR molecules are highly polymorphic, meaning their gene sequences differ greatly between individuals, so that different individuals possess different arrays/repertoires of KIR genes.

Genes

• two domains, long cytoplasmic tail: KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DL5B,
• two domains, short cytoplasmic tail: KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5
• three domains, long cytoplasmic tail: KIR3DL1, KIR3DL2, KIR3DL3
• three domains, short cytoplasmic tail: KIR3DS1

See also

• Leukocyte immunoglobulin-like receptors

References

External links

• http://www.KIRtyping.info
• The KIR Gene Cluster, NIH Bookshelf, PDF
• killer+cell+immunoglobulin-like+receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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• 1. 免疫不全症を引き起こすCD3／T細胞受容体複合体疾患 cd3 t cell receptor complex disorders causing immunodeficiency
• 2. HLAハプロタイプ適合造血細胞移植 hla haploidentical hematopoietic cell transplantation
• 3. T細胞受容体シグナル伝達 t cell receptor signaling
• 4. 造血細胞移植のためのドナー選定 donor selection for hematopoietic cell transplantation
• 5. BおよびTリンパ球の正常な発生 normal b and t lymphocyte development

English Journal

• Association of variably expressed KIR3dl1 alleles with psoriatic disease.

• Berinstein J1,2,3, Pollock R1,2,4, Pellett F1,2, Thavaneswaran A1,2, Chandran V1,2,4,5,6, Gladman DD7,8,9,10.
• Clinical rheumatology.Clin Rheumatol.2017 Aug 11. doi: 10.1007/s10067-017-3784-5. [Epub ahead of print]
• PMID 28801811

• HLA Mismatching Favoring Host-Versus-Graft NK Cell Activity Via KIR3DL1 Is Associated With Improved Outcomes Following Lung Transplantation.

• Greenland JR1,2, Sun H3, Calabrese D2, Chong T2, Singer JP2, Kukreja J4, Hays SR2, Golden JA2,4, Caughey GH1,2,5, Venstrom JM2, Rajalingam R3.
• American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.Am J Transplant.2017 Aug;17(8):2192-2199. doi: 10.1111/ajt.14295. Epub 2017 May 11.
• PMID 28375571

• Partial break in tolerance of NKG2A-/LIR-1- single KIR+ NK cells early in the course of HLA-matched, KIR-mismatched hematopoietic cell transplantation.

• Rathmann S1, Keck C1,2, Kreutz C3, Weit N4, Müller M1, Timmer J3,5, Glatzel S1, Follo M6, Malkovsky M7, Werner M1, Handgretinger R8, Finke J6, Fisch P1.
• Bone marrow transplantation.Bone Marrow Transplant.2017 Aug;52(8):1144-1155. doi: 10.1038/bmt.2017.81. Epub 2017 May 8.
• PMID 28481352

Japanese Journal

• 活性化T細胞におけるNKレセプターの発現

• 野竹 剛,瀧 伸介
• 臨床免疫・アレルギー科 55(4), 475-482, 2011-04
• NAID 40018833143

• NK cell regulation and traditional herbal medicine(Clinical study)

• KOGURE Toshiaki
• 和漢医薬学雑誌 22(Supplement_1), 201-207, 2005
• … Natural killer (NK) cells, the third major lymphocyte population, are important effecter cells against certain infections and tumors. … In recent years, much attention has been paid to the NK cell inhibitory receptors and their interaction with major histocompatibility complex class I molecules on target cells. …
• NAID 110002555193

• GVL効果とNK細胞

• 長澤 正之
• 臨床免疫 41(2), 213-218, 2004-02
• NAID 40006201467

Related Links

• ヒト Killer cell immunoglobulin(Ig)-like receptor (KIR)の構造と機能

構造生物 Vol.5 No.2 1999年9月発行 ヒト Killer cell immunoglobulin(Ig)-like receptor (KIR)の構造と機能 前仲勝実 Laboratory of Molecular ... はじめに 免疫系には初期の感染防御機構である自然免疫と抗原特異的な獲得免疫の2種類の ...

• KIR3DL1 killer cell immunoglobulin-like receptor, three ...

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a ...

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★リンクテーブル★

リンク元	「KIR receptor」「キラー細胞免疫グロブリン様受容体」「killer inhibitory receptor」
関連記事	「like」「kill」「killer」「cell」「killer cell」

「KIR receptor」

　　[★]

KIR受容体、KIRレセプター、抑制化レセプター、キラー細胞抑制受容体、キラー細胞抑制レセプター、キラー免疫グロブリン様受容体

関

killer cell immunoglobulin-like receptor、killer inhibitory receptor

「キラー細胞免疫グロブリン様受容体」

　　[★]

英

killer cell immunoglobulin-like receptor

関

KIR受容体、キラー細胞抑制受容体

「killer inhibitory receptor」

　　[★]

キラー細胞抑制受容体

関

killer cell immunoglobulin-like receptor、KIR receptor

「like」

　　[★]

• v.

• 好む

• prep.

• 似ている、同様の

関

alike、as well as、care for、correspond、correspondingly、equally、favor、identically、likewise、prefer、resemble、same、similar、similarly、such

　 　 　 　 　 　 　 　 　 　

「kill」

　　[★]

• v.

• 殺す、死滅させる

関

killing

linux

option

9 KILL プロセスの強制終了

• ex.

kill -9 process_id

　 　 　 　 　 　 　 　 　 　 　 　 　 　 　

「killer」

　　[★]

• キラー、殺し屋

　 　 　

「cell」

　　[★] 細胞 　 　 　 　 　 　 　

「killer cell」

　　[★]

• キラー細胞

関

K cell