keratomalacia

角膜軟化症

　

WordNet

1. softening and drying and ulceration of the cornea resulting from vitamin A deficiency; symptom of cystic fibrosis or sprue

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/01 18:38:32」(JST)

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Keratomalacia
Classification and external resources
ICD-10	E50.4
ICD-9	264.4, 371.45

Keratomalacia is an eye disorder that results from Vitamin A deficiency. Vitamin A is required to maintain specialized epithelia (such as in the cornea and conjunctiva).

The precise mechanism is still not known, but vitamin A is necessary for the maintenance of the specialized epithelial surfaces of the body. A lack of vitamin A leads to atrophic changes in the normal mucosal surface, with loss of goblet cells, and replacement of the normal epithelium by an inappropriate keratinized stratified squamous epithelium. In addition, the substantia propria of the cornea breaks down and liquefies, resulting in keratomalacia.

The resulting cornea becomes totally opaque. Unfortunately, this is one of the most common reasons for blindness around the world, particularly in developing countries.

See also

• Xerophthalmia
• Keratoconjunctivitis sicca
• Acute Promyelocytic Leukemia
• Vitamin A
• Conjunctiva

References

External links

• Merck
• webMD

UpToDate Contents

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• 1. ビタミンAの概要 overview of vitamin a
• 2. 小児の栄養障害と関連した微量栄養素欠乏 micronutrient deficiencies associated with malnutrition in children

English Journal

• Evaluation of accelerated collagen cross-linking for the treatment of melting keratitis in eight dogs.

• Famose F.SourceService d'Ophtalmologie, Clinique Vétérinaire des Acacias, 42 avenue Lucien Servanty, 31700 Blagnac, France.
• Veterinary ophthalmology.Vet Ophthalmol.2013 Aug 1. doi: 10.1111/vop.12085. [Epub ahead of print]
• OBJECTIVE: Melting keratitis is serious condition presenting a high risk of permanent blindness and is caused by infectious or noninfectious factors. In humans, the clinical efficacy of collagen cross-linking (CXL) has been described in the treatment of refractory infectious keratitis by arresting k
• PMID 23902524

• Use of bovine pericardium (Tutopatch® ) graft for surgical repair of deep melting corneal ulcers in dogs and corneal sequestra in cats.

• Dulaurent T, Azoulay T, Goulle F, Dulaurent A, Mentek M, Peiffer RL, Isard PF.SourceCentre Hospitalier Vétérinaire, 275 Route Impériale, Saint-Martin Bellevue, 74370, France.
• Veterinary ophthalmology.Vet Ophthalmol.2013 Apr 28. doi: 10.1111/vop.12047. [Epub ahead of print]
• OBJECTIVE: To evaluate the efficacy of bovine pericardium (BP) graft in the treatment of deep melting corneal ulcers in three dogs and corneal sequestra in three cats.PROCEDURE: Three dogs with keratomalacia affecting the deep third of the stroma and three cats with corneal sequestrum were evaluated
• PMID 23621151

• Corneal ulcers in horses.

• Williams LB, Pinard CL.SourceUniversity of Guelph, Guelph, Ontario, Canada.
• Compendium (Yardley, PA).Compend Contin Educ Vet.2013 Jan;35(1):E4.
• Corneal ulceration is commonly diagnosed by equine veterinarians. A complete ophthalmic examination as well as fluorescein staining, corneal cytology, and corneal bacterial (aerobic) and fungal culture and sensitivity testing are necessary for all infected corneal ulcers. Appropriate topical antibio
• PMID 23532729

Japanese Journal

• インスリン依存型糖尿病にみられたビタミンA欠乏性角膜軟化症の1例

• 平井 千順,後藤 晋,小林 義治
• 日本眼科紀要 = Folia ophthalmologica Japonica 47(11), 1333-1336, 1996-11-28
• NAID 10012373765

• Xerophthalmia, keratomalacia and nutritional blindness

• SOMMER A
• Int Ophthalmol 14, 195-199, 1990
• NAID 30012380538

Related Links

• keratomalacia - definition of keratomalacia by Medical dictionary

keratomalacia /ker·a·to·ma·la·cia/ (ker″ah-to-mah-la´shah) softening and necrosis of the cornea associated with vitamin A deficiency. ker·a·to·ma·la·cia (k r-t-m-l sh) n. A condition, usually in children with vitamin A deficiency ...

• keratomalacia とは - コトバンク

世界大百科事典 第2版 keratomalaciaの用語解説 - 薬品による化学傷に対しては，受傷直後に大量の水で急速に洗浄することが肝要である。 ビタミンAの不足は，角膜軟化症keratomalaciaを起こし，角膜の乾燥，白濁，穿孔（せんこう）を ...

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リンク元

「角膜軟化症」

「角膜軟化症」

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英

keratomalacia

関

ビタミンA、ビトー斑